GB1391234A - Indole derivatives - Google Patents
Indole derivativesInfo
- Publication number
- GB1391234A GB1391234A GB200573A GB200573A GB1391234A GB 1391234 A GB1391234 A GB 1391234A GB 200573 A GB200573 A GB 200573A GB 200573 A GB200573 A GB 200573A GB 1391234 A GB1391234 A GB 1391234A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- alk
- lower alkyl
- formula
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940054051 antipsychotic indole derivative Drugs 0.000 title abstract 2
- 150000002475 indoles Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 23
- 150000001875 compounds Chemical class 0.000 abstract 7
- 229910052739 hydrogen Inorganic materials 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000001041 indolyl group Chemical group 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- -1 1- piperazinyl Chemical group 0.000 abstract 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 2
- 125000001475 halogen functional group Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical class 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 229910052987 metal hydride Inorganic materials 0.000 abstract 2
- 150000004681 metal hydrides Chemical class 0.000 abstract 2
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 238000007126 N-alkylation reaction Methods 0.000 abstract 1
- DXGTUUQHTDOFFQ-UHFFFAOYSA-N [N].C1=CC=C2NC=CC2=C1 Chemical group [N].C1=CC=C2NC=CC2=C1 DXGTUUQHTDOFFQ-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001350 alkyl halides Chemical class 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000009435 amidation Effects 0.000 abstract 1
- 238000007112 amidation reaction Methods 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- DCBDOYDVQJVXOH-UHFFFAOYSA-N azane;1h-indole Chemical compound N.C1=CC=C2NC=CC2=C1 DCBDOYDVQJVXOH-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00217627A US3852285A (en) | 1972-01-13 | 1972-01-13 | Pyrano- and thiopyranoindole derivatives |
| US297130A US3904617A (en) | 1972-10-12 | 1972-10-12 | Process for preparing new heterocyclic derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1391234A true GB1391234A (en) | 1975-04-16 |
Family
ID=26912101
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB200573A Expired GB1391234A (en) | 1972-01-13 | 1973-01-15 | Indole derivatives |
Country Status (7)
| Country | Link |
|---|---|
| CA (1) | CA978526A (enrdf_load_stackoverflow) |
| DE (1) | DE2301525A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2181671B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1391234A (enrdf_load_stackoverflow) |
| HK (1) | HK22578A (enrdf_load_stackoverflow) |
| IE (1) | IE37060B1 (enrdf_load_stackoverflow) |
| MY (1) | MY7800240A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0035259B1 (en) * | 1980-02-27 | 1984-03-28 | Shionogi & Co., Ltd. | Tetrahydrothiopyrano(3,2-b)indole derivatives, process for their preparation and pharmaceutical composition containing these compounds |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4118394A (en) * | 1976-10-18 | 1978-10-03 | Ayerst, Mckenna & Harrison Limited | Pyrano- and thiopyranoindole derivatives |
| JPS557201A (en) * | 1978-05-23 | 1980-01-19 | Shionogi & Co Ltd | Derivative of tetrahydrothiopyrano(2,3-b)indole |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3142678A (en) * | 1962-01-09 | 1964-07-28 | American Home Prod | Amino substituted penthienoindoles |
-
1973
- 1973-01-05 IE IE1773A patent/IE37060B1/xx unknown
- 1973-01-12 DE DE19732301525 patent/DE2301525A1/de not_active Ceased
- 1973-01-12 FR FR7301148A patent/FR2181671B1/fr not_active Expired
- 1973-01-12 CA CA161,128A patent/CA978526A/en not_active Expired
- 1973-01-15 GB GB200573A patent/GB1391234A/en not_active Expired
-
1978
- 1978-04-27 HK HK22578A patent/HK22578A/xx unknown
- 1978-12-30 MY MY7800240A patent/MY7800240A/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0035259B1 (en) * | 1980-02-27 | 1984-03-28 | Shionogi & Co., Ltd. | Tetrahydrothiopyrano(3,2-b)indole derivatives, process for their preparation and pharmaceutical composition containing these compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| MY7800240A (en) | 1978-12-31 |
| FR2181671A1 (enrdf_load_stackoverflow) | 1973-12-07 |
| DE2301525A1 (de) | 1973-07-19 |
| FR2181671B1 (enrdf_load_stackoverflow) | 1976-07-02 |
| IE37060L (en) | 1973-07-13 |
| CA978526A (en) | 1975-11-25 |
| IE37060B1 (en) | 1977-04-27 |
| HK22578A (en) | 1978-05-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |