GB1390032A - Pharmaceutical compositions - Google Patents
Pharmaceutical compositionsInfo
- Publication number
- GB1390032A GB1390032A GB4042771A GB4042771A GB1390032A GB 1390032 A GB1390032 A GB 1390032A GB 4042771 A GB4042771 A GB 4042771A GB 4042771 A GB4042771 A GB 4042771A GB 1390032 A GB1390032 A GB 1390032A
- Authority
- GB
- United Kingdom
- Prior art keywords
- weight
- component
- aug
- ester
- alcohol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 abstract 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 239000000463 material Substances 0.000 abstract 2
- 229960005489 paracetamol Drugs 0.000 abstract 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 abstract 1
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- 229920002261 Corn starch Polymers 0.000 abstract 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 abstract 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 abstract 1
- 239000004375 Dextrin Substances 0.000 abstract 1
- 229920001353 Dextrin Polymers 0.000 abstract 1
- IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical class OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- 229920001479 Hydroxyethyl methyl cellulose Polymers 0.000 abstract 1
- 235000019759 Maize starch Nutrition 0.000 abstract 1
- 229930195725 Mannitol Natural products 0.000 abstract 1
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical class C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 abstract 1
- 239000004372 Polyvinyl alcohol Substances 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 abstract 1
- 229930006000 Sucrose Natural products 0.000 abstract 1
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical class CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 abstract 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 239000001768 carboxy methyl cellulose Substances 0.000 abstract 1
- 239000001913 cellulose Chemical class 0.000 abstract 1
- 229920002678 cellulose Chemical class 0.000 abstract 1
- 229920001577 copolymer Polymers 0.000 abstract 1
- 235000019425 dextrin Nutrition 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 235000001727 glucose Nutrition 0.000 abstract 1
- 239000008187 granular material Substances 0.000 abstract 1
- -1 hydroxyethyl- Chemical group 0.000 abstract 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
- 239000000594 mannitol Substances 0.000 abstract 1
- 235000010355 mannitol Nutrition 0.000 abstract 1
- QLNWXBAGRTUKKI-UHFFFAOYSA-N metacetamol Chemical compound CC(=O)NC1=CC=CC(O)=C1 QLNWXBAGRTUKKI-UHFFFAOYSA-N 0.000 abstract 1
- 229950009890 metacetamol Drugs 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 229920002451 polyvinyl alcohol Polymers 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 235000010241 potassium sorbate Nutrition 0.000 abstract 1
- 239000004302 potassium sorbate Substances 0.000 abstract 1
- 229940069338 potassium sorbate Drugs 0.000 abstract 1
- 239000003755 preservative agent Substances 0.000 abstract 1
- 230000002335 preservative effect Effects 0.000 abstract 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 abstract 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 abstract 1
- 239000000600 sorbitol Substances 0.000 abstract 1
- 238000001694 spray drying Methods 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000005720 sucrose Substances 0.000 abstract 1
- 235000000346 sugar Nutrition 0.000 abstract 1
- 150000005846 sugar alcohols Chemical class 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4042771A GB1390032A (en) | 1971-08-27 | 1971-08-27 | Pharmaceutical compositions |
| ZA725791A ZA725791B (en) | 1971-08-27 | 1972-08-22 | Granular material suitable for tabletting free-flowing comprising n-acylamino-phenol and water-soluble polymeric organic binder |
| AU45845/72A AU4584572A (en) | 1971-08-27 | 1972-08-22 | Free-flowing granular material |
| DK423272AA DK131418B (da) | 1971-08-27 | 1972-08-25 | Fremgangsmåde til fremstilling og eventuelt tablettering af et fritflydende granulært materiale, der er egnet til tablettering. |
| DE2241960A DE2241960C2 (de) | 1971-08-27 | 1972-08-25 | Freifließendes Granulat zur Tablettenherstellung |
| CA150,153A CA988424A (en) | 1971-08-27 | 1972-08-25 | Pharmaceutical compositions of n-acylaminophenol in a suitable form for tabletting |
| FR7230504A FR2150903B1 (enExample) | 1971-08-27 | 1972-08-28 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB4042771A GB1390032A (en) | 1971-08-27 | 1971-08-27 | Pharmaceutical compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1390032A true GB1390032A (en) | 1975-04-09 |
Family
ID=10414863
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4042771A Expired GB1390032A (en) | 1971-08-27 | 1971-08-27 | Pharmaceutical compositions |
Country Status (7)
| Country | Link |
|---|---|
| AU (1) | AU4584572A (enExample) |
| CA (1) | CA988424A (enExample) |
| DE (1) | DE2241960C2 (enExample) |
| DK (1) | DK131418B (enExample) |
| FR (1) | FR2150903B1 (enExample) |
| GB (1) | GB1390032A (enExample) |
| ZA (1) | ZA725791B (enExample) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5753403A (en) * | 1980-05-20 | 1982-03-30 | Mallinckrodt Chemical Works | Composition containing spray dry particle of n-acetyl-p-aminophenol and manufacture |
| US4562024A (en) * | 1982-07-06 | 1985-12-31 | Sterling Drug Inc. | Process for preparing granulate containing poorly compressible medicinally active matter |
| US4600579A (en) * | 1983-06-07 | 1986-07-15 | Mallinckrodt, Inc. | N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same |
| US4631284A (en) * | 1984-11-19 | 1986-12-23 | Mallinckrodt, Inc. | Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom |
| US4661521A (en) * | 1984-04-30 | 1987-04-28 | Mallinckrodt, Inc. | Direct tableting acetaminophen compositions |
| US4684516A (en) * | 1983-08-01 | 1987-08-04 | Alra Laboratories, Inc. | Sustained release tablets and method of making same |
| AU574345B2 (en) * | 1982-07-06 | 1988-07-07 | Sterling Drug Inc. | Preparing compressed tablets by wet granulation and tablets therefrom |
| US4757090A (en) * | 1986-07-14 | 1988-07-12 | Mallinckrodt, Inc. | Direct tableting acetaminophen compositions |
| WO1989002266A1 (en) * | 1987-09-17 | 1989-03-23 | Mallinckrodt, Inc. | A free-flowing granular composition containing ibuprofen and a method for its preparation |
| WO1994020086A1 (en) * | 1993-03-12 | 1994-09-15 | British Technology Group Limited | Pharmaceutical compositions comprising paracetamol and l-cysteine or a precursor thereof |
| US9724302B2 (en) | 2010-04-09 | 2017-08-08 | Pacira Pharmaceuticals, Inc. | Method for formulating large diameter synthetic membrane vesicles |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR226763A1 (es) * | 1980-12-22 | 1982-08-13 | Monsanto Co | Metodo de preparacion de una granulacion analgesica de acetaminofeno |
| DE3215211A1 (de) * | 1982-04-23 | 1983-10-27 | Akzo Gmbh | Mikroporoese mit wirkstoffen beladene pulver |
| DE3447422A1 (de) * | 1984-12-24 | 1986-06-26 | Basf Ag, 6700 Ludwigshafen | Verfahren zur herstellung von ascorbinsaeure-granulat |
| JPH0780754B2 (ja) * | 1986-08-06 | 1995-08-30 | エーザイ株式会社 | 多顆粒型持続性錠剤 |
| US4820522A (en) * | 1987-07-27 | 1989-04-11 | Mcneilab, Inc. | Oral sustained release acetaminophen formulation and process |
| DE19835124C2 (de) * | 1998-08-04 | 2002-01-03 | Buna Sow Leuna Olefinverb Gmbh | Verfahren zur Herstellung von Stärkeestern mit definierter Kornstruktur für pharmazeutische Zwecke |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3200039A (en) * | 1962-05-28 | 1965-08-10 | Pfizer & Co C | Non-granulated tablets with 20% sorbitol in a particle size of from about 100mu to about 2000mu |
-
1971
- 1971-08-27 GB GB4042771A patent/GB1390032A/en not_active Expired
-
1972
- 1972-08-22 AU AU45845/72A patent/AU4584572A/en not_active Expired
- 1972-08-22 ZA ZA725791A patent/ZA725791B/xx unknown
- 1972-08-25 DE DE2241960A patent/DE2241960C2/de not_active Expired
- 1972-08-25 CA CA150,153A patent/CA988424A/en not_active Expired
- 1972-08-25 DK DK423272AA patent/DK131418B/da not_active IP Right Cessation
- 1972-08-28 FR FR7230504A patent/FR2150903B1/fr not_active Expired
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5753403A (en) * | 1980-05-20 | 1982-03-30 | Mallinckrodt Chemical Works | Composition containing spray dry particle of n-acetyl-p-aminophenol and manufacture |
| US4562024A (en) * | 1982-07-06 | 1985-12-31 | Sterling Drug Inc. | Process for preparing granulate containing poorly compressible medicinally active matter |
| AU574345B2 (en) * | 1982-07-06 | 1988-07-07 | Sterling Drug Inc. | Preparing compressed tablets by wet granulation and tablets therefrom |
| US4600579A (en) * | 1983-06-07 | 1986-07-15 | Mallinckrodt, Inc. | N-acetyl-p-aminophenol compositions containing partially gelatinized starch and method for preparing same |
| US4684516A (en) * | 1983-08-01 | 1987-08-04 | Alra Laboratories, Inc. | Sustained release tablets and method of making same |
| US4661521A (en) * | 1984-04-30 | 1987-04-28 | Mallinckrodt, Inc. | Direct tableting acetaminophen compositions |
| US4631284A (en) * | 1984-11-19 | 1986-12-23 | Mallinckrodt, Inc. | Acetaminophen compositions containing low doses of chlorpheniramine maleate, method for preparing same and tablets formed therefrom |
| US4757090A (en) * | 1986-07-14 | 1988-07-12 | Mallinckrodt, Inc. | Direct tableting acetaminophen compositions |
| WO1989002266A1 (en) * | 1987-09-17 | 1989-03-23 | Mallinckrodt, Inc. | A free-flowing granular composition containing ibuprofen and a method for its preparation |
| WO1994020086A1 (en) * | 1993-03-12 | 1994-09-15 | British Technology Group Limited | Pharmaceutical compositions comprising paracetamol and l-cysteine or a precursor thereof |
| US9724302B2 (en) | 2010-04-09 | 2017-08-08 | Pacira Pharmaceuticals, Inc. | Method for formulating large diameter synthetic membrane vesicles |
| US9730892B2 (en) | 2010-04-09 | 2017-08-15 | Pacira Pharmaceuticals, Inc. | Method for formulating large diameter synthetic membrane vesicles |
| US9737483B2 (en) | 2010-04-09 | 2017-08-22 | Pacira Pharmaceuticals, Inc. | Method for formulating large diameter synthetic membrane vesicles |
| US9737482B2 (en) | 2010-04-09 | 2017-08-22 | Pacira Pharmaceuticals, Inc. | Method for formulating large diameter synthetic membrane vesicles |
| US9757336B2 (en) | 2010-04-09 | 2017-09-12 | Pacira Pharmaceuticals, Inc. | Method for formulating large diameter synthetic membrane vesicles |
| US9808424B2 (en) | 2010-04-09 | 2017-11-07 | Pacira Pharmaceuticals, Inc. | Method for formulating large diameter synthetic membrane vesicles |
| US10045941B2 (en) | 2010-04-09 | 2018-08-14 | Pacira Pharmaceuticals, Inc. | Method for formulating large diameter synthetic membrane vesicles |
| US10398648B2 (en) | 2010-04-09 | 2019-09-03 | Pacira Pharmaceuticals, Inc. | Method for formulating large diameter synthetic membrane vesicles |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2150903B1 (enExample) | 1975-10-17 |
| CA988424A (en) | 1976-05-04 |
| DE2241960A1 (de) | 1973-03-15 |
| DK131418C (enExample) | 1975-12-01 |
| ZA725791B (en) | 1973-05-30 |
| DK131418B (da) | 1975-07-14 |
| FR2150903A1 (enExample) | 1973-04-13 |
| AU4584572A (en) | 1974-02-28 |
| DE2241960C2 (de) | 1982-02-04 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |