GB1385620A - Carbazoles - Google Patents
CarbazolesInfo
- Publication number
- GB1385620A GB1385620A GB3496873A GB3496873A GB1385620A GB 1385620 A GB1385620 A GB 1385620A GB 3496873 A GB3496873 A GB 3496873A GB 3496873 A GB3496873 A GB 3496873A GB 1385620 A GB1385620 A GB 1385620A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- group
- lower alkyl
- formula
- lower alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000001716 carbazoles Chemical class 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 40
- 125000003545 alkoxy group Chemical group 0.000 abstract 33
- 150000001875 compounds Chemical class 0.000 abstract 15
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 13
- -1 nitro, amino Chemical group 0.000 abstract 11
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 9
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 8
- 238000004519 manufacturing process Methods 0.000 abstract 8
- 239000002253 acid Substances 0.000 abstract 6
- 125000002252 acyl group Chemical group 0.000 abstract 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 6
- 125000003277 amino group Chemical group 0.000 abstract 5
- 150000003839 salts Chemical group 0.000 abstract 4
- 150000002148 esters Chemical class 0.000 abstract 3
- 125000005843 halogen group Chemical group 0.000 abstract 3
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- 125000004414 alkyl thio group Chemical group 0.000 abstract 2
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- 101000653791 Bos taurus Protein S100-A12 Proteins 0.000 abstract 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 230000002152 alkylating effect Effects 0.000 abstract 1
- 125000005530 alkylenedioxy group Chemical group 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000003435 antirheumatic agent Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/88—Carbazoles; Hydrogenated carbazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/56—Ring systems containing three or more rings
- C07D209/80—[b, c]- or [b, d]-condensed
- C07D209/82—Carbazoles; Hydrogenated carbazoles
- C07D209/86—Carbazoles; Hydrogenated carbazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the ring system
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pain & Pain Management (AREA)
- Public Health (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27414272A | 1972-07-24 | 1972-07-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1385620A true GB1385620A (en) | 1975-02-26 |
Family
ID=23046965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3496873A Expired GB1385620A (en) | 1972-07-24 | 1973-07-23 | Carbazoles |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS5740144B2 (enExample) |
| KR (1) | KR780000289B1 (enExample) |
| AR (1) | AR205331A1 (enExample) |
| AT (1) | AT325607B (enExample) |
| AU (1) | AU475534B2 (enExample) |
| BE (1) | BE802596A (enExample) |
| CA (1) | CA1026348A (enExample) |
| CH (1) | CH587819A5 (enExample) |
| DD (1) | DD107681A5 (enExample) |
| DE (1) | DE2337340C2 (enExample) |
| DK (1) | DK138537B (enExample) |
| FI (1) | FI59244C (enExample) |
| FR (1) | FR2193611B1 (enExample) |
| GB (1) | GB1385620A (enExample) |
| HK (1) | HK49878A (enExample) |
| HU (1) | HU167611B (enExample) |
| IE (1) | IE37942B1 (enExample) |
| IL (1) | IL42799A (enExample) |
| KE (1) | KE2847A (enExample) |
| LU (1) | LU68071A1 (enExample) |
| MY (1) | MY7800315A (enExample) |
| NL (1) | NL169877C (enExample) |
| NO (1) | NO142865C (enExample) |
| SE (2) | SE402283B (enExample) |
| SU (1) | SU509220A3 (enExample) |
| ZA (1) | ZA734047B (enExample) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0060445A1 (en) * | 1981-03-12 | 1982-09-22 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Process for the resolution of racemates and lactone esters used in said process |
| EP0239306A2 (en) | 1986-03-27 | 1987-09-30 | Merck Frosst Canada Inc. | Tetrahydrocarbazole esters |
| EP0304156A1 (en) * | 1987-07-21 | 1989-02-22 | Merck Frosst Canada Inc. | Cyclohept b indolealkanoic acids |
| RU2182148C2 (ru) * | 1998-06-16 | 2002-05-10 | Пфайзер Продактс Инк. | Способ очистки ди(с1-с6)алкилового сложного эфира (6-хлор-2-карбазолил)метилмалоновой кислоты |
| US7601856B2 (en) | 2006-07-27 | 2009-10-13 | Wyeth | Benzofurans as potassium ion channel modulators |
| US7662831B2 (en) | 2006-07-27 | 2010-02-16 | Wyeth Llc | Tetracyclic indoles as potassium channel modulators |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4146542A (en) * | 1978-06-12 | 1979-03-27 | Hoffmann-La Roche Inc. | Dihydrocarbazole acetic acid and esters thereof |
| US4150031A (en) * | 1978-06-26 | 1979-04-17 | Hoffmann-La Roche Inc. | Hydroxy methyl carbazole acetic acid and esters |
| US4158007A (en) * | 1978-08-21 | 1979-06-12 | Hoffmann-La Roche Inc. | Carbazole methyl malonates |
| JPS6040256U (ja) * | 1983-08-25 | 1985-03-20 | 伊東 璋 | 容器類洗浄機 |
| DE3768097D1 (de) * | 1986-01-23 | 1991-04-04 | Merck Frosst Canada Inc | Tetrahydrocarbazol-1-alkansaeuren. |
| EP0307077A1 (en) * | 1987-07-21 | 1989-03-15 | Merck Frosst Canada Inc. | Tetrahydrocarbazoles for the improvement of cyclosporin therapy |
| PT95692A (pt) * | 1989-10-27 | 1991-09-13 | American Home Prod | Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase |
| JP2004010601A (ja) * | 2002-06-11 | 2004-01-15 | Nippon Steel Chem Co Ltd | インドール誘導体の製造方法及びそのための有用な中間体 |
| JP2006517925A (ja) * | 2003-01-14 | 2006-08-03 | メルク エンド カムパニー インコーポレーテッド | Ａβ４２低下薬としてのジェミナル二置換ＮＳＡＩＤ誘導体 |
| WO2005000457A2 (en) * | 2003-05-06 | 2005-01-06 | Air Products And Chemicals, Inc. | Hydrogen storage reversible hydrogenated of pi-conjugated substrates |
| CA2535497A1 (en) * | 2003-08-15 | 2005-02-24 | Universite Laval | Monomers, oligomers and polymers of 2-functionalized and 2,7-difunctionalized carbazoles |
| CN104010636B (zh) * | 2011-11-15 | 2017-04-12 | 耶路撒冷希伯来大学伊森姆研究发展有限公司 | 三环化合物、包含它们的组合物及其用途 |
| JP5940036B2 (ja) * | 2013-10-08 | 2016-06-29 | テックフィールズ バイオケム カンパニー リミテッド | 非常に速い皮膚透過率を有するアリール−及びヘテロアリールプロピオン酸の正荷電水溶性プロドラッグ |
| JP7747621B2 (ja) * | 2020-03-25 | 2025-10-01 | Jnc株式会社 | 化合物、液晶組成物および液晶表示素子 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD70880A (enExample) * | ||||
| US3580926A (en) * | 1969-11-10 | 1971-05-25 | Parke Davis & Co | Carbazole-4-alkanoic acids and tetrahydrocarbazole-4-alkanoic acids |
| ZA715217B (en) * | 1970-08-20 | 1972-04-26 | Org Nv | Anti-inflammatory preparations |
-
1973
- 1973-01-01 AR AR249230A patent/AR205331A1/es active
- 1973-06-14 ZA ZA734047A patent/ZA734047B/xx unknown
- 1973-06-15 CH CH871673A patent/CH587819A5/xx not_active IP Right Cessation
- 1973-07-20 IL IL42799A patent/IL42799A/en unknown
- 1973-07-20 HU HUHO1597A patent/HU167611B/hu unknown
- 1973-07-20 BE BE133691A patent/BE802596A/xx not_active IP Right Cessation
- 1973-07-20 KR KR7301174A patent/KR780000289B1/ko not_active Expired
- 1973-07-23 AU AU58390/73A patent/AU475534B2/en not_active Expired
- 1973-07-23 GB GB3496873A patent/GB1385620A/en not_active Expired
- 1973-07-23 CA CA177,061A patent/CA1026348A/en not_active Expired
- 1973-07-23 DE DE2337340A patent/DE2337340C2/de not_active Expired
- 1973-07-23 DK DK405973AA patent/DK138537B/da not_active IP Right Cessation
- 1973-07-23 LU LU68071A patent/LU68071A1/xx unknown
- 1973-07-23 SE SE7310244A patent/SE402283B/xx unknown
- 1973-07-23 JP JP48081008A patent/JPS5740144B2/ja not_active Expired
- 1973-07-23 AT AT649773A patent/AT325607B/de not_active IP Right Cessation
- 1973-07-23 DD DD172456A patent/DD107681A5/xx unknown
- 1973-07-23 FI FI2311/73A patent/FI59244C/fi active
- 1973-07-23 IE IE1252/73A patent/IE37942B1/xx unknown
- 1973-07-23 NO NO2975/73A patent/NO142865C/no unknown
- 1973-07-24 NL NLAANVRAGE7310275,A patent/NL169877C/xx not_active IP Right Cessation
- 1973-07-24 SU SU1950151A patent/SU509220A3/ru active
- 1973-07-24 FR FR7327020A patent/FR2193611B1/fr not_active Expired
-
1976
- 1976-05-21 SE SE7605813A patent/SE7605813L/xx unknown
-
1978
- 1978-06-13 KE KE2847A patent/KE2847A/xx unknown
- 1978-08-31 HK HK498/78A patent/HK49878A/xx unknown
- 1978-12-30 MY MY315/78A patent/MY7800315A/xx unknown
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0060445A1 (en) * | 1981-03-12 | 1982-09-22 | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft | Process for the resolution of racemates and lactone esters used in said process |
| EP0239306A2 (en) | 1986-03-27 | 1987-09-30 | Merck Frosst Canada Inc. | Tetrahydrocarbazole esters |
| EP0304156A1 (en) * | 1987-07-21 | 1989-02-22 | Merck Frosst Canada Inc. | Cyclohept b indolealkanoic acids |
| RU2182148C2 (ru) * | 1998-06-16 | 2002-05-10 | Пфайзер Продактс Инк. | Способ очистки ди(с1-с6)алкилового сложного эфира (6-хлор-2-карбазолил)метилмалоновой кислоты |
| US7601856B2 (en) | 2006-07-27 | 2009-10-13 | Wyeth | Benzofurans as potassium ion channel modulators |
| US7662831B2 (en) | 2006-07-27 | 2010-02-16 | Wyeth Llc | Tetracyclic indoles as potassium channel modulators |
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19930722 |