GB1377379A - Production of 7-amino-3-methylcephem compounds - Google Patents
Production of 7-amino-3-methylcephem compoundsInfo
- Publication number
- GB1377379A GB1377379A GB5942471A GB5942471A GB1377379A GB 1377379 A GB1377379 A GB 1377379A GB 5942471 A GB5942471 A GB 5942471A GB 5942471 A GB5942471 A GB 5942471A GB 1377379 A GB1377379 A GB 1377379A
- Authority
- GB
- United Kingdom
- Prior art keywords
- carboxylic acid
- ester
- cephem
- methyl
- aqueous medium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KZVOLMLGLGADDW-NQPNHJOESA-N (6R)-7-amino-3-methyl-5-thia-1-azabicyclo[4.2.0]oct-2-en-8-one Chemical class CC1=CN2[C@H](SC1)C(N)C2=O KZVOLMLGLGADDW-NQPNHJOESA-N 0.000 title 1
- 150000002148 esters Chemical class 0.000 abstract 4
- 150000001408 amides Chemical class 0.000 abstract 3
- 239000012736 aqueous medium Substances 0.000 abstract 3
- 241000223218 Fusarium Species 0.000 abstract 2
- 230000007062 hydrolysis Effects 0.000 abstract 2
- 238000006460 hydrolysis reaction Methods 0.000 abstract 2
- 244000005700 microbiome Species 0.000 abstract 2
- -1 phenylacetyl Chemical group 0.000 abstract 2
- NVIAYEIXYQCDAN-HWZXHQHMSA-N (6r)-7-amino-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical compound S1CC(C)=C(C(O)=O)N2C(=O)C(N)[C@@H]12 NVIAYEIXYQCDAN-HWZXHQHMSA-N 0.000 abstract 1
- UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 abstract 1
- 241000589220 Acetobacter Species 0.000 abstract 1
- 241001019659 Acremonium <Plectosphaerellaceae> Species 0.000 abstract 1
- 241000908198 Actinomucor Species 0.000 abstract 1
- 241000682855 Aegerita Species 0.000 abstract 1
- 241000607534 Aeromonas Species 0.000 abstract 1
- 241000223600 Alternaria Species 0.000 abstract 1
- 241000082448 Anthracobia Species 0.000 abstract 1
- 241000171738 Arthrinium Species 0.000 abstract 1
- 241001327423 Ascotricha Species 0.000 abstract 1
- 241000228212 Aspergillus Species 0.000 abstract 1
- 241000223651 Aureobasidium Species 0.000 abstract 1
- 241000193830 Bacillus <bacterium> Species 0.000 abstract 1
- 241000223679 Beauveria Species 0.000 abstract 1
- 241000123649 Botryotinia Species 0.000 abstract 1
- 241000228337 Byssochlamys Species 0.000 abstract 1
- 241001123632 Cephaloascus Species 0.000 abstract 1
- 229930186147 Cephalosporin Natural products 0.000 abstract 1
- 241001619326 Cephalosporium Species 0.000 abstract 1
- 241000221866 Ceratocystis Species 0.000 abstract 1
- 241001157813 Cercospora Species 0.000 abstract 1
- 241000221955 Chaetomium Species 0.000 abstract 1
- 241000123346 Chrysosporium Species 0.000 abstract 1
- 241000222290 Cladosporium Species 0.000 abstract 1
- 241000222199 Colletotrichum Species 0.000 abstract 1
- 241001327444 Coniochaeta Species 0.000 abstract 1
- 241000609458 Corynespora Species 0.000 abstract 1
- 241001337994 Cryptococcus <scale insect> Species 0.000 abstract 1
- 241000235555 Cunninghamella Species 0.000 abstract 1
- 241000723247 Cylindrocarpon Species 0.000 abstract 1
- 241000122173 Cylindrocladium Species 0.000 abstract 1
- 241000215396 Dactylaria Species 0.000 abstract 1
- 241000123294 Daedaleopsis Species 0.000 abstract 1
- 241001508802 Diaporthe Species 0.000 abstract 1
- 241000190562 Emericellopsis Species 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 241000588722 Escherichia Species 0.000 abstract 1
- 241001620302 Glomerella <beetle> Species 0.000 abstract 1
- 241001248590 Isaria Species 0.000 abstract 1
- 241000223609 Microascus Species 0.000 abstract 1
- 241000721603 Mycoplana Species 0.000 abstract 1
- 241000221960 Neurospora Species 0.000 abstract 1
- 241000187654 Nocardia Species 0.000 abstract 1
- 241001523629 Pestalotiopsis Species 0.000 abstract 1
- 241001136503 Pleospora Species 0.000 abstract 1
- 241000586779 Protaminobacter Species 0.000 abstract 1
- 241000589516 Pseudomonas Species 0.000 abstract 1
- 241000228453 Pyrenophora Species 0.000 abstract 1
- 241000223252 Rhodotorula Species 0.000 abstract 1
- 241001299709 Rosellinia Species 0.000 abstract 1
- 241000235070 Saccharomyces Species 0.000 abstract 1
- 241001489223 Saccharomycodes Species 0.000 abstract 1
- 241001558929 Sclerotium <basidiomycota> Species 0.000 abstract 1
- 241001533598 Septoria Species 0.000 abstract 1
- 241000187747 Streptomyces Species 0.000 abstract 1
- 241000228341 Talaromyces Species 0.000 abstract 1
- 241000228446 Taphrina Species 0.000 abstract 1
- 241000633145 Trichometasphaeria Species 0.000 abstract 1
- 241000082085 Verticillium <Phyllachorales> Species 0.000 abstract 1
- 241000589634 Xanthomonas Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 150000001733 carboxylic acid esters Chemical class 0.000 abstract 1
- 229940124587 cephalosporin Drugs 0.000 abstract 1
- 150000001780 cephalosporins Chemical class 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
- C12P35/02—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin by desacylation of the substituent in the 7 position
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/832—Bacillus
- Y10S435/836—Bacillus licheniformis
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/848—Escherichia
- Y10S435/849—Escherichia coli
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/872—Nocardia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/822—Microorganisms using bacteria or actinomycetales
- Y10S435/886—Streptomyces
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/929—Fusarium
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP45129648A JPS4948760B1 (enrdf_load_stackoverflow) | 1970-12-25 | 1970-12-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1377379A true GB1377379A (en) | 1974-12-11 |
Family
ID=15014700
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5942471A Expired GB1377379A (en) | 1970-12-25 | 1971-12-21 | Production of 7-amino-3-methylcephem compounds |
Country Status (13)
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5341232B2 (enrdf_load_stackoverflow) * | 1972-06-17 | 1978-11-01 | ||
| US4059573A (en) * | 1973-08-01 | 1977-11-22 | Glaxo Laboratories Limited | Extraction of N-blocked amino acids from aqueous media |
| JPS5417032B2 (enrdf_load_stackoverflow) * | 1974-01-23 | 1979-06-27 | ||
| US4001600A (en) * | 1975-06-02 | 1977-01-04 | Watkins-Johnson Company | Interconnecting circuit for ebs diodes and method |
| US3972774A (en) * | 1975-07-28 | 1976-08-03 | Eli Lilly And Company | Enzymatic de-esterification of cephalosporin para-nitrobenzyl esters |
| JPS52143289A (en) * | 1976-05-24 | 1977-11-29 | Meiji Seika Kaisha Ltd | Production of 7-amino-cephem derivatives by filamentous fungi |
| US4230799A (en) * | 1977-02-09 | 1980-10-28 | Schering Corporation | Process for the preparation of antibiotic W-10 complex and for the isolation of Antibiotic 20561 and Antibiotic 20562 therefrom |
| US4316958A (en) * | 1979-02-10 | 1982-02-23 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing optically active cephalosporin analogs |
| US4414328A (en) * | 1980-07-21 | 1983-11-08 | Fujisawa Pharmaceutical Co., Ltd. | Process for the preparation of deacetylcephalosporin C |
| US4316955A (en) * | 1980-11-10 | 1982-02-23 | Eli Lilly And Company | Enzymatic deesterification of cephalosporin methyl esters |
| US4618583A (en) * | 1984-11-19 | 1986-10-21 | E. R. Squibb & Sons, Inc. | Method of preparing L-(+)-β-hydroxyisobutyric acid by fermentation |
| US4981789A (en) * | 1987-03-18 | 1991-01-01 | Merck & Co., Inc. | One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives |
| US5229274A (en) * | 1989-06-27 | 1993-07-20 | Merck & Co., Inc. | Gene encoding one step cephalosporin C amidase and expression thereof in recombinant bacillus |
| US5104800A (en) * | 1989-06-27 | 1992-04-14 | Merck & Co., Inc. | One-step cephalosporin c amidase enzyme |
| GB9216759D0 (en) * | 1992-08-07 | 1992-09-23 | Finpael Spa | Process for the production of 7-amino thiazolyl cephalosporins |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD74282A (enrdf_load_stackoverflow) * | ||||
| FR1357977A (fr) * | 1963-05-20 | 1964-04-10 | Merck & Co Inc | Procédé de production d'acide 7-aminocéphalosphalosporanique par voie enzymatique |
| US3284451A (en) * | 1965-07-22 | 1966-11-08 | Bristol Myers Co | Activated esters of 7-amino-cephalosporanic acid |
| NL150798B (nl) * | 1967-08-07 | 1976-09-15 | Koninklijke Gist Spiritus | Werkwijze voor de bereiding van 7-aminocefalosoranzuur en derivaten daarvan. |
| US3522250A (en) * | 1968-10-15 | 1970-07-28 | American Home Prod | Derivatives of 7-aminocephalosporanic acid |
-
1970
- 1970-12-25 JP JP45129648A patent/JPS4948760B1/ja active Pending
-
1971
- 1971-12-20 US US00210105A patent/US3749641A/en not_active Expired - Lifetime
- 1971-12-21 GB GB5942471A patent/GB1377379A/en not_active Expired
- 1971-12-22 FR FR7146206A patent/FR2120839A5/fr not_active Expired
- 1971-12-22 CA CA130,813A patent/CA1013692A/en not_active Expired
- 1971-12-22 CH CH1874871A patent/CH565186A5/xx not_active IP Right Cessation
- 1971-12-22 NL NLAANVRAGE7117696,A patent/NL175642C/xx not_active IP Right Cessation
- 1971-12-22 DE DE2163791A patent/DE2163791C2/de not_active Expired
- 1971-12-23 SE SE7116583A patent/SE402123B/xx unknown
- 1971-12-23 HU HUTA1161A patent/HU166646B/hu unknown
- 1971-12-23 AT AT1108771A patent/AT320144B/de not_active IP Right Cessation
- 1971-12-24 BE BE777261A patent/BE777261A/xx not_active IP Right Cessation
- 1971-12-24 AU AU37371/71A patent/AU467458B2/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| AU3737171A (en) | 1973-06-28 |
| NL7117696A (enrdf_load_stackoverflow) | 1972-06-27 |
| FR2120839A5 (enrdf_load_stackoverflow) | 1972-08-18 |
| US3749641A (en) | 1973-07-31 |
| AU467458B2 (en) | 1975-12-04 |
| SE402123B (sv) | 1978-06-19 |
| DE2163791A1 (de) | 1972-07-20 |
| JPS4948760B1 (enrdf_load_stackoverflow) | 1974-12-23 |
| NL175642C (nl) | 1984-12-03 |
| BE777261A (fr) | 1972-04-17 |
| CA1013692A (en) | 1977-07-12 |
| CH565186A5 (enrdf_load_stackoverflow) | 1975-08-15 |
| DE2163791C2 (de) | 1985-02-21 |
| AT320144B (de) | 1975-01-27 |
| NL175642B (nl) | 1984-07-02 |
| HU166646B (enrdf_load_stackoverflow) | 1975-04-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| GB1377379A (en) | Production of 7-amino-3-methylcephem compounds | |
| GB1430644A (en) | Automatic vehicle control system | |
| GB1455326A (en) | Radial seal for shafts | |
| ES426272A1 (es) | Un procedimiento para la conversion de un acido 3-aciloxi- metil-cef-3-em-4-carboxilico en su analogo de 3-hidroximeti-lo. | |
| IE39256L (en) | Method of deacylating cephalosporins | |
| ES2110032T3 (es) | Un metodo para la acilacion del grupo amino en 7 del anillo cefalosporanico. | |
| GB1283255A (en) | Improvements in or relating to rotary shaft seals | |
| GB1488822A (en) | Production of cephalosporin c | |
| ES420695A1 (es) | Un procedimiento para la preparacion de acido 6-aminopeni- cilanico. | |
| GB1394544A (en) | Microbial production of biotin | |
| KR890011997A (ko) | 프로테아제 | |
| GB1324159A (en) | Process for producing 7-amino desacetoxy cephalosporanic acid | |
| GB1297955A (enrdf_load_stackoverflow) | ||
| FR2078427A5 (en) | Enzyme-attachment to silicon-contg - materials using activating agents | |
| ES385907A1 (es) | Procedimiento de desdoblamiento para la produccion de acido6-aminopenicilanico. | |
| NL7016560A (en) | Cephalosporins penicillins and cycloheha- - dienyl alkanoic acids | |
| FR2202679A1 (en) | Cephalosporins penicillins and cycloheha- - dienyl alkanoic acids | |
| GB1230365A (enrdf_load_stackoverflow) | ||
| GB1319127A (en) | Asymmetric reduction of secosteroids | |
| GB1288843A (enrdf_load_stackoverflow) | ||
| Kato et al. | Rapid Determination of 7-Acyl-aminocephem Compounds in the Presence of 7-Aminocephem Compounds by Means of Enterobacter β-Lactamase | |
| JPS59129699U (ja) | 船尾管シ−ル組立体 | |
| SE7509168L (sv) | Vetsketetning. | |
| FR2188608A5 (en) | Penicillins prepn by acylating 6-apa - in presence of catalytic enzymes using free acids | |
| NL7412840A (en) | Cephalosporin C prodn - by cultivation of polyene-antibiotic resistant strains of cephalosporin |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 414F | Notice of opposition given (sect. 14/1949) | ||
| 414A | Case decided by the comptroller ** specification amended (sect. 14/1949) | ||
| PS | Patent sealed [section 19, patents act 1949] | ||
| SP | Amendment (slips) printed | ||
| PE20 | Patent expired after termination of 20 years |