GB892144A - Enzymatic production of 6-aminopenicillanic acid - Google Patents

Enzymatic production of 6-aminopenicillanic acid

Info

Publication number
GB892144A
GB892144A GB343959A GB343959A GB892144A GB 892144 A GB892144 A GB 892144A GB 343959 A GB343959 A GB 343959A GB 343959 A GB343959 A GB 343959A GB 892144 A GB892144 A GB 892144A
Authority
GB
United Kingdom
Prior art keywords
penicillin
salt
enzyme
produced
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB343959A
Inventor
George Newbolt Rolinso Richard
Frank Ralph Batchelor
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Research Laboratories Ltd
Original Assignee
Beecham Research Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Research Laboratories Ltd filed Critical Beecham Research Laboratories Ltd
Priority to GB343959A priority Critical patent/GB892144A/en
Priority to ES0255210A priority patent/ES255210A1/en
Priority to BE587030A priority patent/BE587030R/en
Priority to CH101860A priority patent/CH391704A/en
Publication of GB892144A publication Critical patent/GB892144A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/42—Compounds with a free primary amino radical attached in position 6

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

6-aminopenicillanic acid is produced by reacting an enzyme preparation derived from a penicillin amidase producing microorganism with a penicillin of general formula <FORM:0892144/IV (b)/1> or an alkaline earth metal or alkali metal salt thereof, where R is an alkyl or alkenyl group or the group R1XCH2 where R1 is an alkyl, alkenyl, allyl or aryl group and X is O or S, or a fermentation liquor containing such a penicillin or penicillias or salt or salts. Typical penicillins are phenoxymethyl-, butylthiomethyl-, n-heptyl-, 2-pentenyl-, n-amyl- and n-butyl-penicillin, as w e as the natural mixture of penicillins produced by fermentation, including those produced in the formation of 6-aminopenicillanic acid according to Specification 870,396. The penicillin is used in the form of the free acid or a salt with a cation which will not interfere with the enzymatic hydrolysis, e.g. alkali metal and alkaline earth metal salts, e.g. sodium, calcium and potassium salts. The penicillin is added to the enzyme preparation obtained by culturing the producing organism in a suitable medium and which may be in the form of (a) a clarified brew (b) a solution of the dialysed enzyme or (c) a solution of the acetone precipitated enzyme. Specified penicillin amidase-producing organisms are (a) the fungi alternaria tenuis, aspergillus versicolor, Botrytis cinerea, Epicoccum nigrum, Fusarium roseum, Fusarium oxysporum, Mucor hiemalis, Mucor sylvaticus, Penicillium chrysogenum and Trichoderma viride (b) the yeasts Crytococcus albidus and Trichosporon sp. and (c) Streptomyces species.
GB343959A 1959-01-30 1959-01-30 Enzymatic production of 6-aminopenicillanic acid Expired GB892144A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB343959A GB892144A (en) 1959-01-30 1959-01-30 Enzymatic production of 6-aminopenicillanic acid
ES0255210A ES255210A1 (en) 1959-01-30 1960-01-22 Process for the preparation of 6-aminopenicilºnico (Machine-translation by Google Translate, not legally binding)
BE587030A BE587030R (en) 1959-01-30 1960-01-28 Improvements to substances produced by molds producing penicillin.
CH101860A CH391704A (en) 1959-01-30 1960-01-29 Process for the preparation of 6-amino penicillanic acid

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB343959A GB892144A (en) 1959-01-30 1959-01-30 Enzymatic production of 6-aminopenicillanic acid

Publications (1)

Publication Number Publication Date
GB892144A true GB892144A (en) 1962-03-21

Family

ID=9758348

Family Applications (1)

Application Number Title Priority Date Filing Date
GB343959A Expired GB892144A (en) 1959-01-30 1959-01-30 Enzymatic production of 6-aminopenicillanic acid

Country Status (1)

Country Link
GB (1) GB892144A (en)

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