GB1374916A - Isoxazolopyridine carboxylic acids and esters - Google Patents
Isoxazolopyridine carboxylic acids and estersInfo
- Publication number
- GB1374916A GB1374916A GB958672A GB958672A GB1374916A GB 1374916 A GB1374916 A GB 1374916A GB 958672 A GB958672 A GB 958672A GB 958672 A GB958672 A GB 958672A GB 1374916 A GB1374916 A GB 1374916A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- isoxazolopyridine
- formula
- esters
- alkylene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002148 esters Chemical class 0.000 title abstract 2
- SNUZUFNWXTTYEH-UHFFFAOYSA-N [1,2]oxazolo[4,3-b]pyridine-3-carboxylic acid Chemical class C1=CC=NC2=C(C(=O)O)ON=C21 SNUZUFNWXTTYEH-UHFFFAOYSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- NABZXASCLFSKLF-UHFFFAOYSA-N [1,2]oxazolo[4,3-b]pyridine Chemical class C1=CC=NC2=CON=C21 NABZXASCLFSKLF-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- WODLMSKISPEVHO-UHFFFAOYSA-N 2-[diethylamino-(3-methyl-1,2-oxazol-5-yl)methylidene]propanedioic acid Chemical compound CCN(CC)C(=C(C(=O)O)C(=O)O)C1=CC(=NO1)C WODLMSKISPEVHO-UHFFFAOYSA-N 0.000 abstract 1
- BZLZDBKNNQSQIX-UHFFFAOYSA-N 4-hydroxy-1H-[1,2]oxazolo[4,3-b]pyridine Chemical compound ON1C=CC=C2C1=CON2 BZLZDBKNNQSQIX-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000004069 aziridinyl group Chemical group 0.000 abstract 1
- 125000001246 bromo group Chemical group Br* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 230000003834 intracellular effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 125000003226 pyrazolyl group Chemical group 0.000 abstract 1
- -1 pyrrolidino, piperidino, piperazino Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
- C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D261/14—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12919971A | 1971-03-29 | 1971-03-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1374916A true GB1374916A (en) | 1974-11-20 |
Family
ID=22438862
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB958672A Expired GB1374916A (en) | 1971-03-29 | 1972-03-01 | Isoxazolopyridine carboxylic acids and esters |
Country Status (7)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3856799A (en) * | 1971-08-05 | 1974-12-24 | Squibb & Sons Inc | Intermediates for production of amino derivatives of pyrazolopyridine carboxylic acids and esters |
| CH641463A5 (de) * | 1979-11-22 | 1984-02-29 | Lonza Ag | Verfahren zur herstellung von 4,6-diamino-5-cyano-3-aryl-isoxazolo(5,4-b)pyridinen. |
| CH641464A5 (de) * | 1979-11-22 | 1984-02-29 | Lonza Ag | Verfahren zur herstellung von 4-amino-6-hydroxy-3-phenyl-isoxazolo(5,4-b)pyridin-5-carbonitrilen. |
| CA2727250A1 (en) * | 2008-07-01 | 2010-01-07 | Genentech, Inc. | Bicyclic heterocycles as mek kinase inhibitors |
| CN102137843A (zh) * | 2008-07-01 | 2011-07-27 | 健泰科生物技术公司 | 作为mek激酶抑制剂的异吲哚酮衍生物及其使用方法 |
-
1971
- 1971-03-29 US US00129199A patent/US3736326A/en not_active Expired - Lifetime
-
1972
- 1972-03-01 GB GB958672A patent/GB1374916A/en not_active Expired
- 1972-03-16 CA CA137,234A patent/CA970376A/en not_active Expired
- 1972-03-17 DE DE19722213076 patent/DE2213076A1/de active Pending
- 1972-03-20 HU HUSU723A patent/HU162889B/hu unknown
- 1972-03-27 CH CH452172A patent/CH545810A/xx not_active IP Right Cessation
- 1972-03-29 FR FR7211055A patent/FR2132189B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| HU162889B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-04-28 |
| FR2132189A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1972-11-17 |
| DE2213076A1 (de) | 1972-10-19 |
| CH545810A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1974-02-15 |
| CA970376A (en) | 1975-07-01 |
| US3736326A (en) | 1973-05-29 |
| FR2132189B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-10-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |