GB1374463A - Quinoline derivatives - Google Patents

Quinoline derivatives

Info

Publication number
GB1374463A
GB1374463A GB4328071A GB4328071A GB1374463A GB 1374463 A GB1374463 A GB 1374463A GB 4328071 A GB4328071 A GB 4328071A GB 4328071 A GB4328071 A GB 4328071A GB 1374463 A GB1374463 A GB 1374463A
Authority
GB
United Kingdom
Prior art keywords
alkyl
alkoxy
compounds
substituted
halogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4328071A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of GB1374463A publication Critical patent/GB1374463A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1374463 Substituted quinoline-3-carboxylic acids E R SQUIBB & SONS Inc 16 Sept 1971 [18 Sept 1970] 43280/71 Heading C2C [Also in Division A5] The invention comprises compounds of formula and their pharmaceutically acceptable salts, wherein Z is OH, C 1 -C 8 alkoxy, PhO or halogen; R 1 is H or C 1 -C 5 alkyl; R 2 is H, up to C 8 alkyl, alkoxy or alkenyl, C 3 -C 6 -ring cycloalkyl, Ph, CN, halogen, trihalomethyl or haloalkoxy; R 3 , R 4 , R 5 , R 6 are each H or C 1 -C 8 alkyl, or up to 2 of them may be Ph; R 7 is H, C 1 -C 8 alkyl or Ph; each Ph may be substituted and each alkyl or alkoxy may be substituted by Ph. These compounds are prepared by heating a dialkyl carboxyphenylaminomethylenemalonate at above 200‹ C., making the acid chloride of the 3-monoester of the appropriately substituted 4-hydroxyquinolinedicarboxylic acid so formed (the 4-OH group may be simultaneously converted to 4-halogen), and reacting this with the corresponding aziridine; the 4-alkoxy or aryloxy compounds may be made by reacting the 4-OH compounds with the appropriate halide or sulphate; and any of the ester products may be hydrolysed to the corresponding acids.
GB4328071A 1970-09-18 1971-09-16 Quinoline derivatives Expired GB1374463A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7366970A 1970-09-18 1970-09-18
US00306262A US3830817A (en) 1970-09-18 1972-11-13 1-aziridinylcarbonyl-quinoline-carboxylic acid derivatives

Publications (1)

Publication Number Publication Date
GB1374463A true GB1374463A (en) 1974-11-20

Family

ID=26754763

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4328071A Expired GB1374463A (en) 1970-09-18 1971-09-16 Quinoline derivatives

Country Status (6)

Country Link
US (1) US3830817A (en)
CA (1) CA942748A (en)
CH (2) CH550796A (en)
DE (1) DE2146675A1 (en)
FR (1) FR2106612B1 (en)
GB (1) GB1374463A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4476132A (en) * 1981-03-24 1984-10-09 Ciba-Geigy Corporation Acylquinolinone derivatives, and antiallergic preparations and methods of inhibiting allergic reactions using them

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4129737A (en) * 1972-08-02 1978-12-12 Laboratoire Roger Bellon Process for the preparation of an 8-alkyl-5-oxo-5,8-dihydro-pyrido(2,3-d)pyrimidine-6-carboxylic acid
GB8804443D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804448D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804447D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804445D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804444D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds
GB8804446D0 (en) * 1988-02-25 1988-03-23 Smithkline Beckman Intercredit Compounds

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3478084A (en) * 1965-12-22 1969-11-11 Merck & Co Inc Lower alkyl alpha-carboalkoxy-beta-(3,4-disubstituted anilino) acrylates

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4476132A (en) * 1981-03-24 1984-10-09 Ciba-Geigy Corporation Acylquinolinone derivatives, and antiallergic preparations and methods of inhibiting allergic reactions using them

Also Published As

Publication number Publication date
US3830817A (en) 1974-08-20
DE2146675A1 (en) 1972-03-23
CH550796A (en) 1974-06-28
CA942748A (en) 1974-02-26
CH554881A (en) 1974-10-15
FR2106612B1 (en) 1974-11-15
FR2106612A1 (en) 1972-05-05

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees