GB1366834A - Dioxino-quinoline derivates having pharmacological effects - Google Patents
Dioxino-quinoline derivates having pharmacological effectsInfo
- Publication number
- GB1366834A GB1366834A GB583473A GB583473A GB1366834A GB 1366834 A GB1366834 A GB 1366834A GB 583473 A GB583473 A GB 583473A GB 583473 A GB583473 A GB 583473A GB 1366834 A GB1366834 A GB 1366834A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- compound
- chnh
- eto
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000144 pharmacologic effect Effects 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 8
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- 206010030113 Oedema Diseases 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- 230000003301 hydrolyzing effect Effects 0.000 abstract 2
- JXDYKVIHCLTXOP-UHFFFAOYSA-N isatin Chemical compound C1=CC=C2C(=O)C(=O)NC2=C1 JXDYKVIHCLTXOP-UHFFFAOYSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- CCZCXFHJMKINPE-UHFFFAOYSA-N 2-phenylmethoxyphenol Chemical compound OC1=CC=CC=C1OCC1=CC=CC=C1 CCZCXFHJMKINPE-UHFFFAOYSA-N 0.000 abstract 1
- XHVLDDRIGNIVNC-UHFFFAOYSA-N 3-(ethoxymethyl)-2,3-dihydro-1,4-benzodioxine Chemical compound C1=CC=C2OC(COCC)COC2=C1 XHVLDDRIGNIVNC-UHFFFAOYSA-N 0.000 abstract 1
- 206010003445 Ascites Diseases 0.000 abstract 1
- 206010007522 Cardiac asthma Diseases 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- UAGJVSRUFNSIHR-UHFFFAOYSA-N Methyl levulinate Chemical compound COC(=O)CCC(C)=O UAGJVSRUFNSIHR-UHFFFAOYSA-N 0.000 abstract 1
- 206010029164 Nephrotic syndrome Diseases 0.000 abstract 1
- 208000003450 Neurogenic Diabetes Insipidus Diseases 0.000 abstract 1
- 208000008589 Obesity Diseases 0.000 abstract 1
- 208000004327 Paroxysmal Dyspnea Diseases 0.000 abstract 1
- 206010036618 Premenstrual syndrome Diseases 0.000 abstract 1
- 206010037423 Pulmonary oedema Diseases 0.000 abstract 1
- 206010070863 Toxicity to various agents Diseases 0.000 abstract 1
- DUGZEIOARNXYLR-UHFFFAOYSA-N [1,4]dioxino[2,3-g]quinoline Chemical class O1C=COC=2C1=CC=1C=CC=NC=1C=2 DUGZEIOARNXYLR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000004442 acylamino group Chemical group 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal salts Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 238000005915 ammonolysis reaction Methods 0.000 abstract 1
- BNBQRQQYDMDJAH-UHFFFAOYSA-N benzodioxan Chemical compound C1=CC=C2OCCOC2=C1 BNBQRQQYDMDJAH-UHFFFAOYSA-N 0.000 abstract 1
- 230000036772 blood pressure Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 208000028235 central diabetes insipidus Diseases 0.000 abstract 1
- 125000000392 cycloalkenyl group Chemical group 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 201000010064 diabetes insipidus Diseases 0.000 abstract 1
- 125000004985 dialkyl amino alkyl group Chemical group 0.000 abstract 1
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000002934 diuretic Substances 0.000 abstract 1
- 230000001882 diuretic effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000002440 hepatic effect Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 230000006651 lactation Effects 0.000 abstract 1
- 230000001926 lymphatic effect Effects 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- LOTBYPQQWICYBB-UHFFFAOYSA-N methyl n-hexyl-n-[2-(hexylamino)ethyl]carbamate Chemical compound CCCCCCNCCN(C(=O)OC)CCCCCC LOTBYPQQWICYBB-UHFFFAOYSA-N 0.000 abstract 1
- 201000005119 neurohypophyseal diabetes insipidus Diseases 0.000 abstract 1
- 238000006396 nitration reaction Methods 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 230000035935 pregnancy Effects 0.000 abstract 1
- 201000000484 premenstrual tension Diseases 0.000 abstract 1
- 230000000894 saliuretic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000008359 toxicosis Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
- C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
- C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7201675A NL7201675A (enrdf_load_stackoverflow) | 1972-02-09 | 1972-02-09 | |
| NL7215366A NL7215366A (en) | 1972-11-14 | 1972-11-14 | P-dioxino(2,3-g)quinolines - diuretics, saluretics and hypotensives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1366834A true GB1366834A (en) | 1974-09-11 |
Family
ID=26644729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB583473A Expired GB1366834A (en) | 1972-02-09 | 1973-02-06 | Dioxino-quinoline derivates having pharmacological effects |
Country Status (16)
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4036962A (en) * | 1974-08-12 | 1977-07-19 | E. I. Du Pont De Nemours And Co. | 6,7-Methylenedioxy-1-(2,2,2-trifluoroethyl)-4(1H)-quinolone-3-carboxylic acid and its salts and esters |
| US4179506A (en) * | 1978-11-13 | 1979-12-18 | Warner-Lambert Company | New pyridobenzodioxin compounds and methods for their production |
| FR2846327B1 (fr) * | 2002-10-25 | 2006-03-24 | Merck Sante Sas | Derives de n-benzodioxolyl, n-benzodioxanyl et n-benzodioxepinyl arylcarboxamides utilisables dans le traitement de dyslipidemies et compositions pharmaceutiques les contenant. |
| ES2553645T3 (es) * | 2009-03-30 | 2015-12-10 | Vtv Therapeutics Llc | Derivados sustituidos de azoantraceno, composiciones farmacéuticas y métodos de uso de los mismos |
| CN113717185B (zh) * | 2021-08-19 | 2023-04-11 | 云南省烟草农业科学研究院 | 雪茄烟根茎中一种具有抗菌活性的喹啉生物碱化合物及其制备方法和应用 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3178348A (en) * | 1961-02-08 | 1965-04-13 | Norwich Pharma Co | Hypotensive quinolines |
| GB1076828A (en) * | 1963-12-12 | 1967-07-26 | Warner Lambert Pharmaceutical | Methylenedioxy quinoline derivatives |
| DE1908548A1 (de) * | 1968-02-29 | 1970-11-05 | Warner Lambert Co | Chinolinderivate |
| CA942310A (en) * | 1969-07-09 | 1974-02-19 | Mitsuo Nakashita | Preparation of n-substituted 6,7-methylenedioxy-4-quinolone derivatives |
| DE2030899A1 (de) * | 1970-06-18 | 1971-12-23 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Chinolincarbonsäurederivate |
-
0
- BE BE795265D patent/BE795265A/xx not_active IP Right Cessation
-
1973
- 1973-01-25 DE DE2303496A patent/DE2303496A1/de not_active Ceased
- 1973-02-05 CA CA162,916A patent/CA1000279A/en not_active Expired
- 1973-02-05 US US329692A patent/US3865832A/en not_active Expired - Lifetime
- 1973-02-06 CH CH164973A patent/CH593285A5/xx not_active IP Right Cessation
- 1973-02-06 AT AT103773A patent/AT323740B/de not_active IP Right Cessation
- 1973-02-06 SE SE7301634A patent/SE416467B/xx unknown
- 1973-02-06 DK DK63273AA patent/DK138120B/da not_active IP Right Cessation
- 1973-02-06 FI FI349/73A patent/FI55847C/fi active
- 1973-02-06 GB GB583473A patent/GB1366834A/en not_active Expired
- 1973-02-06 IL IL41471A patent/IL41471A/xx unknown
- 1973-02-07 FR FR7304239A patent/FR2181708B1/fr not_active Expired
- 1973-02-07 ES ES411374A patent/ES411374A1/es not_active Expired
- 1973-02-08 AR AR246493A patent/AR211510A1/es active
- 1973-02-08 JP JP1525473A patent/JPS5727112B2/ja not_active Expired
- 1973-02-08 PH PH14326A patent/PH14448A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AT323740B (de) | 1975-07-25 |
| DK138120B (da) | 1978-07-17 |
| PH14448A (en) | 1981-07-23 |
| BE795265A (fr) | 1973-08-09 |
| FI55847B (fi) | 1979-06-29 |
| CH593285A5 (enrdf_load_stackoverflow) | 1977-11-30 |
| IL41471A (en) | 1975-12-31 |
| DE2303496A1 (de) | 1973-08-23 |
| CA1000279A (en) | 1976-11-23 |
| DK138120C (enrdf_load_stackoverflow) | 1978-12-04 |
| US3865832A (en) | 1975-02-11 |
| AR211510A1 (es) | 1978-01-30 |
| FR2181708A1 (enrdf_load_stackoverflow) | 1973-12-07 |
| JPS5727112B2 (enrdf_load_stackoverflow) | 1982-06-08 |
| FR2181708B1 (enrdf_load_stackoverflow) | 1975-10-10 |
| FI55847C (fi) | 1979-10-10 |
| IL41471A0 (en) | 1973-04-30 |
| JPS4886896A (enrdf_load_stackoverflow) | 1973-11-15 |
| SE416467B (sv) | 1981-01-05 |
| ES411374A1 (es) | 1976-07-01 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 732 | Registration of transactions, instruments or events in the register (sect. 32/1977) | ||
| PCNP | Patent ceased through non-payment of renewal fee |