NL7215366A - P-dioxino(2,3-g)quinolines - diuretics, saluretics and hypotensives - Google Patents

P-dioxino(2,3-g)quinolines - diuretics, saluretics and hypotensives

Info

Publication number
NL7215366A
NL7215366A NL7215366A NL7215366A NL7215366A NL 7215366 A NL7215366 A NL 7215366A NL 7215366 A NL7215366 A NL 7215366A NL 7215366 A NL7215366 A NL 7215366A NL 7215366 A NL7215366 A NL 7215366A
Authority
NL
Netherlands
Prior art keywords
alkyl
saluretics
hypotensives
diuretics
halo
Prior art date
Application number
NL7215366A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to BE795265D priority Critical patent/BE795265A/en
Application filed filed Critical
Priority to NL7215366A priority patent/NL7215366A/en
Priority to DE2303496A priority patent/DE2303496A1/en
Priority to US329692A priority patent/US3865832A/en
Priority to CA162,916A priority patent/CA1000279A/en
Priority to CH164973A priority patent/CH593285A5/xx
Priority to AT103773A priority patent/AT323740B/en
Priority to FI349/73A priority patent/FI55847C/en
Priority to GB583473A priority patent/GB1366834A/en
Priority to DK63273AA priority patent/DK138120B/en
Priority to IL41471A priority patent/IL41471A/en
Priority to SE7301634A priority patent/SE416467B/en
Priority to FR7304239A priority patent/FR2181708B1/fr
Priority to ES411374A priority patent/ES411374A1/en
Priority to AR246493A priority patent/AR211510A1/en
Priority to JP1525473A priority patent/JPS5727112B2/ja
Priority to PH14326A priority patent/PH14448A/en
Publication of NL7215366A publication Critical patent/NL7215366A/en
Priority to US05/529,291 priority patent/US3959473A/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/20—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring with substituents attached to the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Cpds. (where R1 = (a) -COR5, R5 = alkoxy, dialkylaminoalkoxy, alkoxyalkoxy, cycloalkoxy or cycloalkylalkoxy of =4C except where R3 = halo or CF3 when they may have =6C; OH, NH2, H or 1-3C alkyl; (b) CHR4OR6, R6 = H or 2-4C acyl; R4 = H or 1-3C alkyl; (c) 1-4C alkyl; R2 = (a) (CH2)nOR7, R7 = H, alkyl, cycloalkyl, cycloalkenyl, alkenyl, alkoxyalkyl or tetrahydrofuranylalkyl of =6C, 2-4 acyl, =8C phenylalkyl, dialkylaminoalkyl, n = 1 or 2; (b) (CH2)nS(O)mR8,R8 = 1-3C alkyl, n = 1 or 2, m = 0, 1 or 2; R3 = H, halo, 1-4C alkyl or alkoxy, CN or HO; R = OH, SH, 1-3C alkoxy or alkylthio, or when R3 = halo or CF3 (sic) R may be Cl or Br). (I) are diuretics saluretics and hypotensives and may be prepd. by various standard methods e.g. cyclisation of reaction prod. of malonate esters with substd. 7-amino-1,4-benzodioxans.
NL7215366A 1972-02-09 1972-11-14 P-dioxino(2,3-g)quinolines - diuretics, saluretics and hypotensives NL7215366A (en)

Priority Applications (18)

Application Number Priority Date Filing Date Title
BE795265D BE795265A (en) 1972-02-09 NEW DERIVATIVES OF QUINOLEINE WITH PHARMACOLOGICAL ACTIVITY
NL7215366A NL7215366A (en) 1972-11-14 1972-11-14 P-dioxino(2,3-g)quinolines - diuretics, saluretics and hypotensives
DE2303496A DE2303496A1 (en) 1972-02-09 1973-01-25 NEW CHINOLINE DERIVATIVES WITH PHARMACOLOGICAL EFFECT
US329692A US3865832A (en) 1972-02-09 1973-02-05 Substituted, 6,7 ethylenedioxy 4 hydroxy 3 non oxo carbonylic quinolines
CA162,916A CA1000279A (en) 1972-02-09 1973-02-05 Quinoline derivatives having pharmacological effects
DK63273AA DK138120B (en) 1972-02-09 1973-02-06 Analogous process for the preparation of quinoline derivatives or their tautomers, or alkali metal salts or acid addition salts thereof.
AT103773A AT323740B (en) 1972-02-09 1973-02-06 PROCESS FOR THE PREPARATION OF NEW QUINOLINE DERIVATIVES AND THEIR SALT
FI349/73A FI55847C (en) 1972-02-09 1973-02-06 PROCEDURE FOR FRAMSTARING WITH SAOSOM DIURETTER AND SALURETER ANVAENDBARA SUBSTITUERADE 2,3-DIHYDRO-9-HYDROXI-P-DIOXINO- (2,3-G) KINOLINDERIVAT
GB583473A GB1366834A (en) 1972-02-09 1973-02-06 Dioxino-quinoline derivates having pharmacological effects
CH164973A CH593285A5 (en) 1972-02-09 1973-02-06
IL41471A IL41471A (en) 1972-02-09 1973-02-06 Quinoline derivatives,their production and pharmaceutical compositions containing them
SE7301634A SE416467B (en) 1972-02-09 1973-02-06 WANT TO MAKE NEW CHINOLINE DERIVATIVES WITH PHARMACOLOGICAL EFFECT
FR7304239A FR2181708B1 (en) 1972-02-09 1973-02-07
ES411374A ES411374A1 (en) 1972-02-09 1973-02-07 Substituted, 6,7 ethylenedioxy 4 hydroxy 3 non oxo carbonylic quinolines
AR246493A AR211510A1 (en) 1972-02-09 1973-02-08 METHOD FOR PRODUCING NEW DERIVATIVES OF 2,3-DIHYDRO-9-HYDROXY-P-DIOXINO (2,3) -G-QUINOLINE
JP1525473A JPS5727112B2 (en) 1972-02-09 1973-02-08
PH14326A PH14448A (en) 1972-02-09 1973-02-08 P-dioxino(2,3-g)quinoline derivatives,their pharmaceutical preparation and method of using same
US05/529,291 US3959473A (en) 1972-02-09 1974-12-04 Quinoline derivatives having pharmacological effects

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL7215366A NL7215366A (en) 1972-11-14 1972-11-14 P-dioxino(2,3-g)quinolines - diuretics, saluretics and hypotensives

Publications (1)

Publication Number Publication Date
NL7215366A true NL7215366A (en) 1974-05-16

Family

ID=19817359

Family Applications (1)

Application Number Title Priority Date Filing Date
NL7215366A NL7215366A (en) 1972-02-09 1972-11-14 P-dioxino(2,3-g)quinolines - diuretics, saluretics and hypotensives

Country Status (1)

Country Link
NL (1) NL7215366A (en)

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Legal Events

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Free format text: DUPHAR INTERNATIONAL RESEARCH B.V.

BV The patent application has lapsed