GB1363382A - Alpha.alpha-diarylimidazole-2-methanols - Google Patents
Alpha.alpha-diarylimidazole-2-methanolsInfo
- Publication number
- GB1363382A GB1363382A GB541872A GB4118372A GB1363382A GB 1363382 A GB1363382 A GB 1363382A GB 541872 A GB541872 A GB 541872A GB 4118372 A GB4118372 A GB 4118372A GB 1363382 A GB1363382 A GB 1363382A
- Authority
- GB
- United Kingdom
- Prior art keywords
- substituted
- halogen
- alkyl
- compound
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 5
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 imidazole compound Chemical class 0.000 abstract 4
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- UWNADWZGEHDQAB-UHFFFAOYSA-N 2,5-dimethylhexane Chemical group CC(C)CCC(C)C UWNADWZGEHDQAB-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000003153 chemical reaction reagent Substances 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 2
- XFEFIWMLQUBMOH-UHFFFAOYSA-N 1-(methoxymethyl)imidazole-2-carboxylic acid Chemical compound COCN1C=CN=C1C(O)=O XFEFIWMLQUBMOH-UHFFFAOYSA-N 0.000 abstract 1
- JUVDEAXMLQQRFP-UHFFFAOYSA-N 1h-imidazol-2-yl(phenyl)methanone Chemical compound C=1C=CC=CC=1C(=O)C1=NC=CN1 JUVDEAXMLQQRFP-UHFFFAOYSA-N 0.000 abstract 1
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000002830 appetite depressant Substances 0.000 abstract 1
- RWCCWEUUXYIKHB-UHFFFAOYSA-N benzophenone Chemical compound C=1C=CC=CC=1C(=O)C1=CC=CC=C1 RWCCWEUUXYIKHB-UHFFFAOYSA-N 0.000 abstract 1
- 239000012965 benzophenone Substances 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 201000011243 gastrointestinal stromal tumor Diseases 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 150000002460 imidazoles Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 125000002088 tosyl group Chemical group [H]C1=C([H])C(=C([H])C([H])=C1C([H])([H])[H])S(*)(=O)=O 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/90—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Priority Applications (20)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE794940D BE794940A (fr) | 1972-02-04 | Nouveaux composes anorexigenes | |
| GB541872A GB1363382A (en) | 1972-02-04 | 1972-09-05 | Alpha.alpha-diarylimidazole-2-methanols |
| ES411222A ES411222A1 (es) | 1972-02-04 | 1973-02-02 | Procedimiento para la obtencion de alfa, alfa-diarilimida- zol-2-metanoles. |
| CH148373A CH594630A5 (enrdf_load_html_response) | 1972-02-04 | 1973-02-02 | |
| LU66953A LU66953A1 (enrdf_load_html_response) | 1972-02-04 | 1973-02-02 | |
| AU51774/73A AU467008B2 (en) | 1972-02-04 | 1973-02-02 | d, d-DIARYLIMIDAZOLE-2-METHANOLS |
| CS73810A CS187368B2 (en) | 1972-02-04 | 1973-02-02 | Method of producing alpha,alpha-diaryl-2-imidazolyl methanols |
| CA162,792A CA979899A (en) | 1972-02-04 | 1973-02-02 | Imidazolemethanols |
| NO442/73A NO137233C (no) | 1972-02-04 | 1973-02-02 | Analogifremgangsm}te for fremstilling av terapeutisk aktive alfa, alfa-diarylimidazol-2-metanoler og syreaddisjonssalter derav |
| IL41448A IL41448A (en) | 1972-02-04 | 1973-02-02 | Alpha alpha-diphenylimidazole-2-methanol derivatives their preparation and pharmaceutical compositions containing them |
| HUGI187A HU166406B (enrdf_load_html_response) | 1972-02-04 | 1973-02-02 | |
| FR7303708A FR2173984B1 (enrdf_load_html_response) | 1972-02-04 | 1973-02-02 | |
| AT91473A AT322545B (de) | 1972-02-04 | 1973-02-02 | Verfahren zur herstellung neuer alpha,alpha-diarylimidazol-2-methanole und ihrer salze |
| NL7301494A NL7301494A (enrdf_load_html_response) | 1972-02-04 | 1973-02-02 | |
| FI325/73A FI57936C (fi) | 1972-02-04 | 1973-02-02 | Analogifoerfarande foer framstaellning av terapeutiskt aktiva alfa,alfa-diarylimidazol-2-metanoler |
| DE2305212A DE2305212A1 (de) | 1972-02-04 | 1973-02-02 | Alpha,alpha-diarylimidazol-2-methanole, ihre salze, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate |
| AT457074A AT334891B (de) | 1972-02-04 | 1974-06-04 | Verfahren zur herstellung neuer alfa,alfa-diarylimidazol-2-methanole und ihrer salze |
| AT457174A AT334892B (de) | 1972-09-05 | 1974-06-04 | Verfahren zur herstellung neuer alfa,alfa-diarylimidazol-2-methanole und deren salze |
| CS757021A CS187392B2 (en) | 1972-02-04 | 1975-10-17 | Method of producing alpha,alpha-diaryl-2-imidazolyl methanols |
| CS757022A CS187393B2 (en) | 1972-09-05 | 1975-10-17 | Method of producing alpha,alpha-diaryl-2-imidazolyl methanols |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB541872 | 1972-02-04 | ||
| GB541872A GB1363382A (en) | 1972-02-04 | 1972-09-05 | Alpha.alpha-diarylimidazole-2-methanols |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1363382A true GB1363382A (en) | 1974-08-14 |
Family
ID=26239878
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB541872A Expired GB1363382A (en) | 1972-02-04 | 1972-09-05 | Alpha.alpha-diarylimidazole-2-methanols |
Country Status (16)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001030327A3 (de) * | 1999-10-27 | 2002-03-14 | Aventis Pharma Gmbh | Verwendung von 2-imidazolyl-substituierten carbinolen zur herstellung eines medikaments zur behandlung oder prophylaxe von durch ischämischen zuständen |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2139489A4 (en) * | 2007-03-23 | 2011-11-02 | Merck Sharp & Dohme | Mineralocorticoid receptor modulators |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2899441A (en) * | 1959-08-11 | Chjchjoh |
-
0
- BE BE794940D patent/BE794940A/xx unknown
-
1972
- 1972-09-05 GB GB541872A patent/GB1363382A/en not_active Expired
-
1973
- 1973-02-02 NL NL7301494A patent/NL7301494A/xx not_active Application Discontinuation
- 1973-02-02 FI FI325/73A patent/FI57936C/fi active
- 1973-02-02 ES ES411222A patent/ES411222A1/es not_active Expired
- 1973-02-02 CH CH148373A patent/CH594630A5/xx not_active IP Right Cessation
- 1973-02-02 FR FR7303708A patent/FR2173984B1/fr not_active Expired
- 1973-02-02 CA CA162,792A patent/CA979899A/en not_active Expired
- 1973-02-02 NO NO442/73A patent/NO137233C/no unknown
- 1973-02-02 DE DE2305212A patent/DE2305212A1/de not_active Ceased
- 1973-02-02 LU LU66953A patent/LU66953A1/xx unknown
- 1973-02-02 HU HUGI187A patent/HU166406B/hu unknown
- 1973-02-02 CS CS73810A patent/CS187368B2/cs unknown
- 1973-02-02 AT AT91473A patent/AT322545B/de not_active IP Right Cessation
- 1973-02-02 IL IL41448A patent/IL41448A/en unknown
- 1973-02-02 AU AU51774/73A patent/AU467008B2/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001030327A3 (de) * | 1999-10-27 | 2002-03-14 | Aventis Pharma Gmbh | Verwendung von 2-imidazolyl-substituierten carbinolen zur herstellung eines medikaments zur behandlung oder prophylaxe von durch ischämischen zuständen |
| RU2257205C2 (ru) * | 1999-10-27 | 2005-07-27 | Авентис Фарма Дойчланд Гмбх | Применение 2-имидазолилзамещенных карбинолов для получения лекарственного средства для лечения или профилактики заболеваний, обусловленных ишемическими состояниями |
Also Published As
| Publication number | Publication date |
|---|---|
| FR2173984A1 (enrdf_load_html_response) | 1973-10-12 |
| NO137233C (no) | 1978-01-25 |
| CA979899A (en) | 1975-12-16 |
| ES411222A1 (es) | 1975-12-01 |
| BE794940A (fr) | 1973-08-02 |
| HU166406B (enrdf_load_html_response) | 1975-03-28 |
| FR2173984B1 (enrdf_load_html_response) | 1976-08-13 |
| DE2305212A1 (de) | 1973-08-16 |
| FI57936C (fi) | 1980-11-10 |
| CS187368B2 (en) | 1979-01-31 |
| FI57936B (fi) | 1980-07-31 |
| IL41448A (en) | 1977-07-31 |
| AU5177473A (en) | 1974-08-08 |
| AU467008B2 (en) | 1975-11-13 |
| NL7301494A (enrdf_load_html_response) | 1973-08-07 |
| IL41448A0 (en) | 1973-04-30 |
| NO137233B (no) | 1977-10-17 |
| LU66953A1 (enrdf_load_html_response) | 1973-04-19 |
| AT322545B (de) | 1975-05-26 |
| CH594630A5 (enrdf_load_html_response) | 1978-01-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |