GB1360959A - Arylpiperazines and processes for their preparation - Google Patents
Arylpiperazines and processes for their preparationInfo
- Publication number
- GB1360959A GB1360959A GB43573A GB43573A GB1360959A GB 1360959 A GB1360959 A GB 1360959A GB 43573 A GB43573 A GB 43573A GB 43573 A GB43573 A GB 43573A GB 1360959 A GB1360959 A GB 1360959A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- alkyl
- give
- reacted
- dichloro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Aryl piperazines Chemical class 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 229910052799 carbon Inorganic materials 0.000 abstract 4
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- ITILIGUXRVVZPQ-UHFFFAOYSA-N 1,5-dichlorohex-4-en-3-one Chemical compound CC(Cl)=CC(=O)CCCl ITILIGUXRVVZPQ-UHFFFAOYSA-N 0.000 abstract 2
- PNLQPWWBHXMFCA-UHFFFAOYSA-N 2-chloroprop-1-ene Chemical compound CC(Cl)=C PNLQPWWBHXMFCA-UHFFFAOYSA-N 0.000 abstract 2
- INUNLMUAPJVRME-UHFFFAOYSA-N 3-chloropropanoyl chloride Chemical compound ClCCC(Cl)=O INUNLMUAPJVRME-UHFFFAOYSA-N 0.000 abstract 2
- OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052801 chlorine Inorganic materials 0.000 abstract 2
- MWWATHDPGQKSAR-UHFFFAOYSA-N propyne Chemical compound CC#C MWWATHDPGQKSAR-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- KNKRKFALVUDBJE-UHFFFAOYSA-N 1,2-dichloropropane Chemical compound CC(Cl)CCl KNKRKFALVUDBJE-UHFFFAOYSA-N 0.000 abstract 1
- ZKAWUFVOGOQZCP-UHFFFAOYSA-N 1,4-dichlorohex-4-en-3-one Chemical compound ClCCC(C(=CC)Cl)=O ZKAWUFVOGOQZCP-UHFFFAOYSA-N 0.000 abstract 1
- WMOLMMJIWSZYBP-UHFFFAOYSA-N 1,5,5-trichlorohexan-3-one Chemical compound CC(Cl)(Cl)CC(=O)CCCl WMOLMMJIWSZYBP-UHFFFAOYSA-N 0.000 abstract 1
- LOJRPFYUCXISQX-UHFFFAOYSA-N 2,8-dichlorooct-2-en-4-one Chemical compound ClCCCCC(C=C(C)Cl)=O LOJRPFYUCXISQX-UHFFFAOYSA-N 0.000 abstract 1
- IAMALOVTVCLUKP-UHFFFAOYSA-N 2-chlorobut-2-enoyl chloride Chemical compound CC=C(Cl)C(Cl)=O IAMALOVTVCLUKP-UHFFFAOYSA-N 0.000 abstract 1
- CYQNXLFYWHJZFV-UHFFFAOYSA-N 2-chlorohepta-2,5-dien-4-one Chemical compound ClC(C)=CC(C=CC)=O CYQNXLFYWHJZFV-UHFFFAOYSA-N 0.000 abstract 1
- ATANUYPSKXKEDC-UHFFFAOYSA-N 3-chlorobutanoyl chloride Chemical compound CC(Cl)CC(Cl)=O ATANUYPSKXKEDC-UHFFFAOYSA-N 0.000 abstract 1
- DCAJMPNCCYROBP-UHFFFAOYSA-N 5-chlorohexa-1,4-dien-3-one Chemical compound ClC(=CC(C=C)=O)C DCAJMPNCCYROBP-UHFFFAOYSA-N 0.000 abstract 1
- SVNNWKWHLOJLOK-UHFFFAOYSA-N 5-chloropentanoyl chloride Chemical compound ClCCCCC(Cl)=O SVNNWKWHLOJLOK-UHFFFAOYSA-N 0.000 abstract 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 abstract 1
- 239000005977 Ethylene Substances 0.000 abstract 1
- JLTDJTHDQAWBAV-UHFFFAOYSA-N N,N-dimethylaniline Chemical compound CN(C)C1=CC=CC=C1 JLTDJTHDQAWBAV-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 150000007824 aliphatic compounds Chemical class 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000005278 alkyl sulfonyloxy group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001728 carbonyl compounds Chemical class 0.000 abstract 1
- GLUUGHFHXGJENI-UHFFFAOYSA-N diethylenediamine Natural products C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002429 hydrazines Chemical class 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C17/00—Preparation of halogenated hydrocarbons
- C07C17/093—Preparation of halogenated hydrocarbons by replacement by halogens
- C07C17/16—Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722201889 DE2201889A1 (de) | 1972-01-15 | 1972-01-15 | Arylpiperazine und verfahren zu ihrer herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1360959A true GB1360959A (en) | 1974-07-24 |
Family
ID=5833112
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB43573A Expired GB1360959A (en) | 1972-01-15 | 1973-01-03 | Arylpiperazines and processes for their preparation |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US3926999A (enExample) |
| JP (1) | JPS504085A (enExample) |
| AT (1) | AT329062B (enExample) |
| AU (1) | AU465081B2 (enExample) |
| BE (1) | BE793955A (enExample) |
| BR (1) | BR7300224D0 (enExample) |
| CH (1) | CH587270A5 (enExample) |
| DD (1) | DD104080A5 (enExample) |
| DE (1) | DE2201889A1 (enExample) |
| DK (1) | DK134177C (enExample) |
| EG (1) | EG10986A (enExample) |
| ES (1) | ES410618A1 (enExample) |
| FR (1) | FR2168357B1 (enExample) |
| GB (1) | GB1360959A (enExample) |
| HU (1) | HU165959B (enExample) |
| IL (1) | IL40854A (enExample) |
| NL (1) | NL7215334A (enExample) |
| PL (1) | PL83741B1 (enExample) |
| RO (1) | RO62763A (enExample) |
| SE (1) | SE397530B (enExample) |
| ZA (1) | ZA728625B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5496334A (en) * | 1978-01-17 | 1979-07-30 | Oki Electric Ind Co Ltd | Digital signal bus |
| US4182862A (en) * | 1978-10-18 | 1980-01-08 | Rohm And Haas Company | Process for the preparation of 1,3-disubstituted-2-azoyl-2-propen-1-ones |
| CA1248531A (en) * | 1984-04-17 | 1989-01-10 | Jeffrey C. Watkins | 4-substituted piperazine-2-carboxylic acids |
| US4562189A (en) * | 1984-10-09 | 1985-12-31 | American Cyanamid Company | Pyrazolylpiperazines |
| US20040082717A1 (en) * | 2002-06-24 | 2004-04-29 | Southwest Research Institute | Keratin-silicone copolymers and interpenetrating networks (IPN's), methods of production and methods of use thereof |
| US20050130989A1 (en) * | 2003-01-28 | 2005-06-16 | Aventis Pharma S. A. | N-arylheteroaromatic products compositions containing them and use thereof |
| DE10315573A1 (de) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazole |
| DE10315569A1 (de) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazolverbindungen |
| DE10315572A1 (de) * | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Substituierte Pyrazole |
| DE10315571A1 (de) | 2003-04-05 | 2004-10-14 | Merck Patent Gmbh | Pyrazolverbindungen |
| KR100868353B1 (ko) * | 2007-03-08 | 2008-11-12 | 한국화학연구원 | 도파민 ｄ4 수용체 길항제인 신규 피페라지닐프로필피라졸유도체, 이의 제조방법 및 이를 포함하는 약학적 조성물 |
| KR101955691B1 (ko) | 2010-03-30 | 2019-03-07 | 베르선 코포레이션 | 트롬빈 억제제로서의 다중치환된 방향족 화합물 |
| RU2015144193A (ru) | 2013-03-15 | 2017-04-24 | Версеон Корпорейшн | Галогенпиразолы в качестве ингибиторов тромбина |
| BR112015022340A2 (pt) | 2013-03-15 | 2017-07-18 | Verseon Corp | método para tratamento ou prevenção de uma doença ou distúrbio relacionado à calicreína em um sujeito, composto, e, composição farmacêutica |
| MX2017003624A (es) | 2014-09-17 | 2017-07-13 | Verseon Corp | Compuestos de piridona sustituida con pirazolilo como inhibidores de serina proteasas. |
| JP2018506563A (ja) | 2015-02-27 | 2018-03-08 | ヴァーセオン コーポレイション | セリンプロテアーゼ阻害剤としての置換ピラゾール化合物 |
| US12479816B2 (en) | 2019-02-08 | 2025-11-25 | University of Pittsburgh—of the Commonwealth System of Higher Education | 20-HETE formation inhibitors |
-
0
- BE BE793955D patent/BE793955A/xx unknown
-
1972
- 1972-01-15 DE DE19722201889 patent/DE2201889A1/de active Pending
- 1972-11-13 NL NL7215334A patent/NL7215334A/xx not_active Application Discontinuation
- 1972-11-15 IL IL40854A patent/IL40854A/en unknown
- 1972-12-04 SE SE7215765A patent/SE397530B/xx unknown
- 1972-12-05 ZA ZA728625A patent/ZA728625B/xx unknown
- 1972-12-08 AU AU49852/72A patent/AU465081B2/en not_active Expired
- 1972-12-19 RO RO7200073209A patent/RO62763A/ro unknown
- 1972-12-29 PL PL1972159971A patent/PL83741B1/xx unknown
-
1973
- 1973-01-03 GB GB43573A patent/GB1360959A/en not_active Expired
- 1973-01-05 DK DK6773A patent/DK134177C/da active
- 1973-01-09 US US322184A patent/US3926999A/en not_active Expired - Lifetime
- 1973-01-10 EG EG9/73A patent/EG10986A/xx active
- 1973-01-11 BR BR73224A patent/BR7300224D0/pt unknown
- 1973-01-12 HU HUME1592A patent/HU165959B/hu unknown
- 1973-01-12 DD DD168218A patent/DD104080A5/xx unknown
- 1973-01-12 AT AT26273*#A patent/AT329062B/de not_active IP Right Cessation
- 1973-01-13 ES ES410618A patent/ES410618A1/es not_active Expired
- 1973-01-13 JP JP48006335A patent/JPS504085A/ja active Pending
- 1973-01-15 FR FR7301270A patent/FR2168357B1/fr not_active Expired
- 1973-01-15 CH CH52673A patent/CH587270A5/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| ZA728625B (en) | 1973-08-29 |
| US3926999A (en) | 1975-12-16 |
| PL83741B1 (enExample) | 1976-01-31 |
| DE2201889A1 (de) | 1973-07-19 |
| ATA26273A (de) | 1975-07-15 |
| EG10986A (en) | 1976-11-30 |
| AT329062B (de) | 1976-04-26 |
| NL7215334A (enExample) | 1973-07-17 |
| SE397530B (sv) | 1977-11-07 |
| FR2168357B1 (enExample) | 1975-10-31 |
| DK134177C (da) | 1977-02-28 |
| ES410618A1 (es) | 1976-06-01 |
| BR7300224D0 (pt) | 1973-10-25 |
| BE793955A (fr) | 1973-07-12 |
| IL40854A0 (en) | 1973-01-30 |
| HU165959B (enExample) | 1974-12-28 |
| AU465081B2 (en) | 1975-09-18 |
| CH587270A5 (enExample) | 1977-04-29 |
| RO62763A (fr) | 1978-01-15 |
| FR2168357A1 (enExample) | 1973-08-31 |
| JPS504085A (enExample) | 1975-01-16 |
| AU4985272A (en) | 1974-06-13 |
| DK134177B (da) | 1976-09-27 |
| DD104080A5 (enExample) | 1974-02-20 |
| IL40854A (en) | 1976-03-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |