GB1354538A - 6,11-dihydrodibenzo-b,e-thiepine derivatives - Google Patents
6,11-dihydrodibenzo-b,e-thiepine derivativesInfo
- Publication number
- GB1354538A GB1354538A GB3285171A GB3285171A GB1354538A GB 1354538 A GB1354538 A GB 1354538A GB 3285171 A GB3285171 A GB 3285171A GB 3285171 A GB3285171 A GB 3285171A GB 1354538 A GB1354538 A GB 1354538A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- july
- methyl
- metal salt
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- -1 alkali metal salt Chemical class 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- 150000004967 organic peroxy acids Chemical class 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- KTBOWZRPDZLHQT-UHFFFAOYSA-N 5-oxo-6,11-dihydrobenzo[c][1]benzothiepin-11-ol Chemical compound C1S(=O)C2=CC=CC=C2C(O)C2=CC=CC=C21 KTBOWZRPDZLHQT-UHFFFAOYSA-N 0.000 abstract 1
- JLRRONOEUGUFFI-UHFFFAOYSA-N 6,11-dihydrobenzo[c][1]benzothiepin-11-ol Chemical compound C1SC2=CC=CC=C2C(O)C2=CC=CC=C21 JLRRONOEUGUFFI-UHFFFAOYSA-N 0.000 abstract 1
- DGGKXQQCVPAUEA-UHFFFAOYSA-N 8-azabicyclo[3.2.1]octane Chemical class C1CCC2CCC1N2 DGGKXQQCVPAUEA-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- 208000007107 Stomach Ulcer Diseases 0.000 abstract 1
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 abstract 1
- 229960004373 acetylcholine Drugs 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229960001340 histamine Drugs 0.000 abstract 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- QWXYZCJEXYQNEI-OSZHWHEXSA-N intermediate I Chemical compound COC(=O)[C@@]1(C=O)[C@H]2CC=[N+](C\C2=C\C)CCc2c1[nH]c1ccccc21 QWXYZCJEXYQNEI-OSZHWHEXSA-N 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- KHIWWQKSHDUIBK-UHFFFAOYSA-N periodic acid Chemical compound OI(=O)(=O)=O KHIWWQKSHDUIBK-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 231100000820 toxicity test Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D337/00—Heterocyclic compounds containing rings of more than six members having one sulfur atom as the only ring hetero atom
- C07D337/02—Seven-membered rings
- C07D337/06—Seven-membered rings condensed with carbocyclic rings or ring systems
- C07D337/10—Seven-membered rings condensed with carbocyclic rings or ring systems condensed with two six-membered rings
- C07D337/12—[b,e]-condensed
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1073670A CH529783A (de) | 1970-07-15 | 1970-07-15 | Verfahren zur Herstellung neuer Dibenzothiepinderivate |
| CH1073770A CH529784A (de) | 1970-07-15 | 1970-07-15 | Verfahren zur Herstellung neuer Dibenzothiepinderivate |
| CH1073570A CH528538A (de) | 1970-07-15 | 1970-07-15 | Verfahren zur Herstellung neuer Dibenzothiepinderivate |
| CH1073870A CH529785A (de) | 1970-07-15 | 1970-07-15 | Verfahren zur Herstellung neuer Dibenzothiepinderivate |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1354538A true GB1354538A (en) | 1974-06-05 |
Family
ID=27429316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3285171A Expired GB1354538A (en) | 1970-07-15 | 1971-07-13 | 6,11-dihydrodibenzo-b,e-thiepine derivatives |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3716544A (enrdf_load_stackoverflow) |
| AU (1) | AU3116571A (enrdf_load_stackoverflow) |
| BE (1) | BE769968A (enrdf_load_stackoverflow) |
| DE (1) | DE2134820A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2100908B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1354538A (enrdf_load_stackoverflow) |
| HU (1) | HU163777B (enrdf_load_stackoverflow) |
| NL (1) | NL7109301A (enrdf_load_stackoverflow) |
| SE (1) | SE368955B (enrdf_load_stackoverflow) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3558107A (en) * | 1968-07-29 | 1971-01-26 | William Thomas Williams | Foaming agent mixer and method |
| CH582699A5 (enrdf_load_stackoverflow) * | 1973-03-26 | 1976-12-15 | Sandoz Ag | |
| CA1307790C (en) * | 1987-08-04 | 1992-09-22 | Ian Anthony Cliffe | Ethers |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3234235A (en) * | 1962-01-19 | 1966-02-08 | American Home Prod | Heterocyclic carbinols |
| CH476015A (de) * | 1965-06-28 | 1969-07-31 | Sandoz Ag | Verfahren zur Herstellung neuer Tropanäther |
| US3519633A (en) * | 1967-08-02 | 1970-07-07 | Mead Johnson & Co | Certain substituted 5,11-dihydro-10,10-dioxo - dibenz(c,f)(1,2)thiazepin - 5 - yloxyamines |
-
1971
- 1971-07-06 NL NL7109301A patent/NL7109301A/xx unknown
- 1971-07-13 DE DE19712134820 patent/DE2134820A1/de active Pending
- 1971-07-13 AU AU31165/71A patent/AU3116571A/en not_active Expired
- 1971-07-13 BE BE769968A patent/BE769968A/xx unknown
- 1971-07-13 GB GB3285171A patent/GB1354538A/en not_active Expired
- 1971-07-13 US US00162290A patent/US3716544A/en not_active Expired - Lifetime
- 1971-07-13 FR FR7125570A patent/FR2100908B1/fr not_active Expired
- 1971-07-13 HU HUSA2220A patent/HU163777B/hu unknown
- 1971-07-14 SE SE09119/71A patent/SE368955B/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE2134820A1 (de) | 1972-01-20 |
| HU163777B (enrdf_load_stackoverflow) | 1973-10-27 |
| SE368955B (enrdf_load_stackoverflow) | 1974-07-29 |
| NL7109301A (enrdf_load_stackoverflow) | 1972-01-18 |
| US3716544A (en) | 1973-02-13 |
| FR2100908B1 (enrdf_load_stackoverflow) | 1975-02-07 |
| BE769968A (fr) | 1972-01-13 |
| FR2100908A1 (enrdf_load_stackoverflow) | 1972-03-24 |
| AU3116571A (en) | 1973-01-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |