GB1346037A - 2-(indanyl-4 2-amino)-delta 2 imidazoline and its salts processes for producing the same and pharmaceutical compositions containing the same - Google Patents

2-(indanyl-4 2-amino)-delta 2 imidazoline and its salts processes for producing the same and pharmaceutical compositions containing the same

Info

Publication number
GB1346037A
GB1346037A GB33461/72*2A GB3346172A GB1346037A GB 1346037 A GB1346037 A GB 1346037A GB 3346172 A GB3346172 A GB 3346172A GB 1346037 A GB1346037 A GB 1346037A
Authority
GB
United Kingdom
Prior art keywords
imidazoline
amino
indanyl
same
indenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB33461/72*2A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nordmark Werke GmbH
Original Assignee
Nordmark Werke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nordmark Werke GmbH filed Critical Nordmark Werke GmbH
Publication of GB1346037A publication Critical patent/GB1346037A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1346037 2 - (Indanyl - 4<SP>1</SP> amino) - #<SP>2</SP>- imidazoline NORDMARK-WERKE GmbH 18 July 1972 [21 July 1971] 33461/72 Heading C2C 2 - (Indanyl - 41 - amino) - #<SP>2</SP> - imidazoline and its acid addition salts, are prepared (1) by reacting a compound II in which R is or CN where R 1 is C 1-6 alkyl with ethylene diamine or a monosalt thereof (2) subjecting N-(4-indanyl)-N<SP>1</SP>-(#-aminoethyl) urea or thiourea to ring closure by heating to a temperature between 130-200‹ C. C. (3) reacting 4-aminoindene with a compound (V) in which R 1 is C 1-6 alkyl or with bis-(2-oxo-1- imidazoledinyl)phosphuryl chloride (4) reacting an indenyl-4-isocyanide dihalogenide in which the halogen in chlorine or bromine with ethylene diamine or (5) partially hydrogenating 2-(indenyl - 41 - amino) - #<SP>2</SP> - imidazoline either with a catalyst (Raney-Nickel) at elevated temperature and pressure or using nascent hydrogen. 2 - (Indenyl - 41 - amino) - #<SP>2</SP> - imidazoline and its acid-addition salts possess vasoconstrictor properties and form with a carrier or diluent a pharmaceutical composition.
GB33461/72*2A 1971-07-21 1972-07-18 2-(indanyl-4 2-amino)-delta 2 imidazoline and its salts processes for producing the same and pharmaceutical compositions containing the same Expired GB1346037A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2136325A DE2136325C3 (en) 1971-07-21 1971-07-21 2- (Indanyl-4'-amino) Delta to the power of 2imidazoline, its physiologically harmless acid addition salts, processes for their production and pharmaceuticals

Publications (1)

Publication Number Publication Date
GB1346037A true GB1346037A (en) 1974-02-06

Family

ID=5814273

Family Applications (1)

Application Number Title Priority Date Filing Date
GB33461/72*2A Expired GB1346037A (en) 1971-07-21 1972-07-18 2-(indanyl-4 2-amino)-delta 2 imidazoline and its salts processes for producing the same and pharmaceutical compositions containing the same

Country Status (15)

Country Link
JP (1) JPS5418260B1 (en)
AT (1) AT315832B (en)
BE (1) BE786499A (en)
CA (1) CA967162A (en)
CH (1) CH571502A5 (en)
DE (1) DE2136325C3 (en)
DK (1) DK137642C (en)
ES (1) ES404607A1 (en)
FR (1) FR2146430B1 (en)
GB (1) GB1346037A (en)
LU (1) LU65687A1 (en)
NL (1) NL173639C (en)
SE (1) SE405114B (en)
YU (1) YU34878B (en)
ZA (1) ZA724747B (en)

Also Published As

Publication number Publication date
DE2136325A1 (en) 1973-02-08
NL173639C (en) 1984-02-16
LU65687A1 (en) 1972-10-30
SE405114B (en) 1978-11-20
DK137642B (en) 1978-04-10
DE2136325C3 (en) 1974-08-22
CH571502A5 (en) 1976-01-15
JPS5418260B1 (en) 1979-07-06
DK137642C (en) 1978-09-25
YU34878B (en) 1980-04-30
DE2136325B2 (en) 1974-01-17
CA967162A (en) 1975-05-06
ZA724747B (en) 1973-04-25
NL7209138A (en) 1973-01-23
NL173639B (en) 1983-09-16
AT315832B (en) 1974-06-10
FR2146430B1 (en) 1975-06-20
ES404607A1 (en) 1975-06-16
FR2146430A1 (en) 1973-03-02
YU180772A (en) 1979-10-31
BE786499A (en) 1972-11-16

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Legal Events

Date Code Title Description
PS Patent sealed
PE20 Patent expired after termination of 20 years