ES404607A1 - 2-(indanyl-4 2-amino)-delta 2 imidazoline and its salts processes for producing the same and pharmaceutical compositions containing the same - Google Patents

2-(indanyl-4 2-amino)-delta 2 imidazoline and its salts processes for producing the same and pharmaceutical compositions containing the same

Info

Publication number
ES404607A1
ES404607A1 ES404607A ES404607A ES404607A1 ES 404607 A1 ES404607 A1 ES 404607A1 ES 404607 A ES404607 A ES 404607A ES 404607 A ES404607 A ES 404607A ES 404607 A1 ES404607 A1 ES 404607A1
Authority
ES
Spain
Prior art keywords
formula
amino
transformed
imidazoline
see formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES404607A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nordmark Werke GmbH
Original Assignee
Nordmark Werke GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nordmark Werke GmbH filed Critical Nordmark Werke GmbH
Publication of ES404607A1 publication Critical patent/ES404607A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Procedure for the preparation of 2- (indani-4'-amino- Δ 2-imidazoline and its acid addition salts, whose 2- (indani-41-amino) Δ 2-imidazoline and its acid addition salts corresponds to formula I ** (See formula) ** characterized by the fact that: A) an indanyl-4-isothiauronium salt, or the corresponding free base, -thiourea, -guanidin, -nitroguanidin or -cyanimide of formula II ** (See formula) ** where R is one of the groups ** (See formula) ** R1 means a low molecular weight alkyl moiety and X an acid anion, which is transformed with ethylenediamine, and optionally in the form of one of its monosalts, or B) an N- (4-indanyl) -N'- (β-aminoethyl) -urea of the formula III ** (See formula) ** where Y means oxygen or sulfur, closes in a ring or c) 4-amino-indane of formula IV ** (See formula) ** is transformed with 2-alkylmercapto- Δ 2-imidazoline of formula V ** (See formula) ** D) 4-amino-indane of formula IV is transformed with Bis- (2-oxo-1-imidazoli-dinyl) -phosphine chloride of formula VI ** (See formula) ** E) an indanyl-4-isocyanido-dihalogenide of the formula VII ** (See formula) ** where Hal means chlorine or bromine, it is transformed with ethylenediamine or F) 2- (indenyl-4'-amino) - Δ 2-imidazoline of formula VIII ** (See formula) ** it is partially hydrogenated, and if necessary the obtained salts are transformed into free bases or the free bases are transformed into salts. (Machine-translation by Google Translate, not legally binding)
ES404607A 1971-07-21 1972-07-06 2-(indanyl-4 2-amino)-delta 2 imidazoline and its salts processes for producing the same and pharmaceutical compositions containing the same Expired ES404607A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE2136325A DE2136325C3 (en) 1971-07-21 1971-07-21 2- (Indanyl-4'-amino) Delta to the power of 2imidazoline, its physiologically harmless acid addition salts, processes for their production and pharmaceuticals

Publications (1)

Publication Number Publication Date
ES404607A1 true ES404607A1 (en) 1975-06-16

Family

ID=5814273

Family Applications (1)

Application Number Title Priority Date Filing Date
ES404607A Expired ES404607A1 (en) 1971-07-21 1972-07-06 2-(indanyl-4 2-amino)-delta 2 imidazoline and its salts processes for producing the same and pharmaceutical compositions containing the same

Country Status (15)

Country Link
JP (1) JPS5418260B1 (en)
AT (1) AT315832B (en)
BE (1) BE786499A (en)
CA (1) CA967162A (en)
CH (1) CH571502A5 (en)
DE (1) DE2136325C3 (en)
DK (1) DK137642C (en)
ES (1) ES404607A1 (en)
FR (1) FR2146430B1 (en)
GB (1) GB1346037A (en)
LU (1) LU65687A1 (en)
NL (1) NL173639C (en)
SE (1) SE405114B (en)
YU (1) YU34878B (en)
ZA (1) ZA724747B (en)

Also Published As

Publication number Publication date
GB1346037A (en) 1974-02-06
NL7209138A (en) 1973-01-23
YU34878B (en) 1980-04-30
NL173639B (en) 1983-09-16
CA967162A (en) 1975-05-06
FR2146430A1 (en) 1973-03-02
DE2136325B2 (en) 1974-01-17
AT315832B (en) 1974-06-10
DK137642B (en) 1978-04-10
DK137642C (en) 1978-09-25
BE786499A (en) 1972-11-16
YU180772A (en) 1979-10-31
SE405114B (en) 1978-11-20
CH571502A5 (en) 1976-01-15
FR2146430B1 (en) 1975-06-20
JPS5418260B1 (en) 1979-07-06
NL173639C (en) 1984-02-16
ZA724747B (en) 1973-04-25
DE2136325C3 (en) 1974-08-22
LU65687A1 (en) 1972-10-30
DE2136325A1 (en) 1973-02-08

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19931022