ES404607A1 - 2-(indanyl-4 2-amino)-delta 2 imidazoline and its salts processes for producing the same and pharmaceutical compositions containing the same - Google Patents
2-(indanyl-4 2-amino)-delta 2 imidazoline and its salts processes for producing the same and pharmaceutical compositions containing the sameInfo
- Publication number
- ES404607A1 ES404607A1 ES404607A ES404607A ES404607A1 ES 404607 A1 ES404607 A1 ES 404607A1 ES 404607 A ES404607 A ES 404607A ES 404607 A ES404607 A ES 404607A ES 404607 A1 ES404607 A1 ES 404607A1
- Authority
- ES
- Spain
- Prior art keywords
- formula
- amino
- transformed
- imidazoline
- see formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Procedure for the preparation of 2- (indani-4'-amino- Δ 2-imidazoline and its acid addition salts, whose 2- (indani-41-amino) Δ 2-imidazoline and its acid addition salts corresponds to formula I ** (See formula) ** characterized by the fact that: A) an indanyl-4-isothiauronium salt, or the corresponding free base, -thiourea, -guanidin, -nitroguanidin or -cyanimide of formula II ** (See formula) ** where R is one of the groups ** (See formula) ** R1 means a low molecular weight alkyl moiety and X an acid anion, which is transformed with ethylenediamine, and optionally in the form of one of its monosalts, or B) an N- (4-indanyl) -N'- (β-aminoethyl) -urea of the formula III ** (See formula) ** where Y means oxygen or sulfur, closes in a ring or c) 4-amino-indane of formula IV ** (See formula) ** is transformed with 2-alkylmercapto- Δ 2-imidazoline of formula V ** (See formula) ** D) 4-amino-indane of formula IV is transformed with Bis- (2-oxo-1-imidazoli-dinyl) -phosphine chloride of formula VI ** (See formula) ** E) an indanyl-4-isocyanido-dihalogenide of the formula VII ** (See formula) ** where Hal means chlorine or bromine, it is transformed with ethylenediamine or F) 2- (indenyl-4'-amino) - Δ 2-imidazoline of formula VIII ** (See formula) ** it is partially hydrogenated, and if necessary the obtained salts are transformed into free bases or the free bases are transformed into salts. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE2136325A DE2136325C3 (en) | 1971-07-21 | 1971-07-21 | 2- (Indanyl-4'-amino) Delta to the power of 2imidazoline, its physiologically harmless acid addition salts, processes for their production and pharmaceuticals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES404607A1 true ES404607A1 (en) | 1975-06-16 |
Family
ID=5814273
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES404607A Expired ES404607A1 (en) | 1971-07-21 | 1972-07-06 | 2-(indanyl-4 2-amino)-delta 2 imidazoline and its salts processes for producing the same and pharmaceutical compositions containing the same |
Country Status (15)
| Country | Link |
|---|---|
| JP (1) | JPS5418260B1 (en) |
| AT (1) | AT315832B (en) |
| BE (1) | BE786499A (en) |
| CA (1) | CA967162A (en) |
| CH (1) | CH571502A5 (en) |
| DE (1) | DE2136325C3 (en) |
| DK (1) | DK137642C (en) |
| ES (1) | ES404607A1 (en) |
| FR (1) | FR2146430B1 (en) |
| GB (1) | GB1346037A (en) |
| LU (1) | LU65687A1 (en) |
| NL (1) | NL173639C (en) |
| SE (1) | SE405114B (en) |
| YU (1) | YU34878B (en) |
| ZA (1) | ZA724747B (en) |
-
1971
- 1971-07-21 DE DE2136325A patent/DE2136325C3/en not_active Expired
-
1972
- 1972-06-30 NL NLAANVRAGE7209138,A patent/NL173639C/en not_active IP Right Cessation
- 1972-07-06 ES ES404607A patent/ES404607A1/en not_active Expired
- 1972-07-07 LU LU65687D patent/LU65687A1/xx unknown
- 1972-07-11 YU YU1807/72A patent/YU34878B/en unknown
- 1972-07-11 ZA ZA724747A patent/ZA724747B/en unknown
- 1972-07-12 CH CH1046772A patent/CH571502A5/xx not_active IP Right Cessation
- 1972-07-17 AT AT613272A patent/AT315832B/en not_active IP Right Cessation
- 1972-07-18 GB GB33461/72*2A patent/GB1346037A/en not_active Expired
- 1972-07-20 BE BE786499A patent/BE786499A/en not_active IP Right Cessation
- 1972-07-20 FR FR7226211A patent/FR2146430B1/fr not_active Expired
- 1972-07-20 SE SE7209575A patent/SE405114B/en unknown
- 1972-07-20 CA CA147,578A patent/CA967162A/en not_active Expired
- 1972-07-21 JP JP7264972A patent/JPS5418260B1/ja active Pending
- 1972-07-21 DK DK361972A patent/DK137642C/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| BE786499A (en) | 1972-11-16 |
| SE405114B (en) | 1978-11-20 |
| DK137642B (en) | 1978-04-10 |
| LU65687A1 (en) | 1972-10-30 |
| NL173639B (en) | 1983-09-16 |
| CA967162A (en) | 1975-05-06 |
| YU34878B (en) | 1980-04-30 |
| GB1346037A (en) | 1974-02-06 |
| NL173639C (en) | 1984-02-16 |
| DE2136325B2 (en) | 1974-01-17 |
| DK137642C (en) | 1978-09-25 |
| FR2146430A1 (en) | 1973-03-02 |
| DE2136325C3 (en) | 1974-08-22 |
| ZA724747B (en) | 1973-04-25 |
| AT315832B (en) | 1974-06-10 |
| DE2136325A1 (en) | 1973-02-08 |
| NL7209138A (en) | 1973-01-23 |
| FR2146430B1 (en) | 1975-06-20 |
| JPS5418260B1 (en) | 1979-07-06 |
| CH571502A5 (en) | 1976-01-15 |
| YU180772A (en) | 1979-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19931022 |