GB1325065A - Imidazoline derivatives - Google Patents
Imidazoline derivativesInfo
- Publication number
- GB1325065A GB1325065A GB4694070A GB4694070A GB1325065A GB 1325065 A GB1325065 A GB 1325065A GB 4694070 A GB4694070 A GB 4694070A GB 4694070 A GB4694070 A GB 4694070A GB 1325065 A GB1325065 A GB 1325065A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- formula above
- isoindol
- imidazo
- dihydro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002462 imidazolines Chemical class 0.000 title 1
- 229940083254 peripheral vasodilators imidazoline derivative Drugs 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 5
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- -1 trifluoromethylphenyl Chemical group 0.000 abstract 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000005036 alkoxyphenyl group Chemical group 0.000 abstract 1
- 125000003282 alkyl amino group Chemical group 0.000 abstract 1
- 125000005037 alkyl phenyl group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000001430 anti-depressive effect Effects 0.000 abstract 1
- 239000000935 antidepressant agent Substances 0.000 abstract 1
- 229940005513 antidepressants Drugs 0.000 abstract 1
- 239000002585 base Substances 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000012458 free base Substances 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- FDDDEECHVMSUSB-UHFFFAOYSA-N sulfanilamide Chemical compound NC1=CC=C(S(N)(=O)=O)C=C1 FDDDEECHVMSUSB-UHFFFAOYSA-N 0.000 abstract 1
- 229940124530 sulfonamide Drugs 0.000 abstract 1
- 150000003456 sulfonamides Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1098470A | 1970-02-12 | 1970-02-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1325065A true GB1325065A (en) | 1973-08-01 |
Family
ID=21748356
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4694070A Expired GB1325065A (en) | 1970-02-12 | 1970-10-02 | Imidazoline derivatives |
| GB2099772A Expired GB1325066A (en) | 1970-02-12 | 1970-10-02 | Phthalimidine compounds |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2099772A Expired GB1325066A (en) | 1970-02-12 | 1970-10-02 | Phthalimidine compounds |
Country Status (15)
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8618158B2 (en) | 2008-06-25 | 2013-12-31 | Cancer Research Technology Limited | Therapeutic agents |
| US10526311B2 (en) | 2015-09-29 | 2020-01-07 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity |
| US10544132B2 (en) | 2015-09-29 | 2020-01-28 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity |
| US11236047B2 (en) | 2017-03-28 | 2022-02-01 | Astex Therapeutics Limited | Combination of isoindolinone derivatives with SGI-110 |
| US11603367B2 (en) | 2017-03-28 | 2023-03-14 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-P53 interaction and process for making them |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2509730A1 (fr) * | 1981-07-17 | 1983-01-21 | Carpibem | Nouveaux phenols o-halogenes et o-substitues par un heterocycle, leur procede de preparation, medicaments les contenant, notamment anti-hypertenseurs, et nouveaux intermediaires de synthese |
| DE3403730A1 (de) * | 1984-02-03 | 1985-08-08 | Hoechst Ag, 6230 Frankfurt | Isoindole, verfahren zu ihrer herstellung und ihre verwendung in der landwirtschaft |
| DE3876314D1 (de) * | 1987-07-01 | 1993-01-14 | Ciba Geigy Ag | Substituierte imidazolone mit herbizider wirkung. |
| GB0419481D0 (en) * | 2004-09-02 | 2004-10-06 | Cancer Rec Tech Ltd | Isoindolin-1-one derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3888846A (en) * | 1967-03-30 | 1975-06-10 | Hoffmann La Roche | Process for 2(2-(1,3-diazacycloalk-2-enyl))benzophenone derivatives and 1,3-diazacycloalkenyl(2,1-a)isoindole derivatives |
-
1970
- 1970-10-02 CY CY786A patent/CY786A/xx unknown
- 1970-10-02 GB GB4694070A patent/GB1325065A/en not_active Expired
- 1970-10-02 CY CY787A patent/CY787A/xx unknown
- 1970-10-02 GB GB2099772A patent/GB1325066A/en not_active Expired
-
1971
- 1971-01-19 IL IL36017A patent/IL36017A/xx unknown
- 1971-01-19 ZA ZA710337A patent/ZA71337B/xx unknown
- 1971-01-20 CA CA103212A patent/CA936533A/en not_active Expired
- 1971-02-03 EG EG55/71A patent/EG10508A/xx active
- 1971-02-04 JP JP446571A patent/JPS5542997B1/ja active Pending
- 1971-02-09 CH CH1546373A patent/CH557350A/xx not_active IP Right Cessation
- 1971-02-09 CH CH192471A patent/CH557366A/xx not_active IP Right Cessation
- 1971-02-11 NL NLAANVRAGE7101847,A patent/NL175722C/xx not_active IP Right Cessation
- 1971-02-11 FR FR7104659A patent/FR2081505B1/fr not_active Expired
- 1971-02-11 SE SE7101742A patent/SE410460B/sv unknown
- 1971-02-11 BE BE762824A patent/BE762824A/xx not_active IP Right Cessation
- 1971-02-12 DE DE2106694A patent/DE2106694C2/de not_active Expired
- 1971-02-12 ES ES388196A patent/ES388196A1/es not_active Expired
-
1975
- 1975-12-30 MY MY60/75A patent/MY7500060A/xx unknown
- 1975-12-30 MY MY62/75A patent/MY7500062A/xx unknown
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8618158B2 (en) | 2008-06-25 | 2013-12-31 | Cancer Research Technology Limited | Therapeutic agents |
| US9358222B2 (en) | 2008-06-25 | 2016-06-07 | Cancer Research Technology Limited | Therapeutic agents |
| US10414726B2 (en) | 2008-06-25 | 2019-09-17 | Cancer Research Technology Limited | Therapeutic agents |
| US10526311B2 (en) | 2015-09-29 | 2020-01-07 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity |
| US10544132B2 (en) | 2015-09-29 | 2020-01-28 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity |
| US10981898B2 (en) | 2015-09-29 | 2021-04-20 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-p53 interaction having anticancer activity |
| US11261171B1 (en) | 2015-09-29 | 2022-03-01 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity |
| US12071429B2 (en) | 2015-09-29 | 2024-08-27 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-P53 interaction having anticancer activity |
| US11236047B2 (en) | 2017-03-28 | 2022-02-01 | Astex Therapeutics Limited | Combination of isoindolinone derivatives with SGI-110 |
| US11603367B2 (en) | 2017-03-28 | 2023-03-14 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-P53 interaction and process for making them |
| US12077526B2 (en) | 2017-03-28 | 2024-09-03 | Astex Therapeutics Limited | Isoindolinone inhibitors of the MDM2-P53 interaction and process for making them |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2106694C2 (de) | 1984-04-12 |
| GB1325066A (en) | 1973-08-01 |
| MY7500062A (en) | 1975-12-31 |
| CH557350A (de) | 1974-12-31 |
| IL36017A (en) | 1975-03-13 |
| EG10508A (en) | 1976-03-31 |
| NL175722B (nl) | 1984-07-16 |
| CA936533A (en) | 1973-11-06 |
| ZA71337B (en) | 1972-08-30 |
| ES388196A1 (es) | 1974-03-01 |
| NL175722C (nl) | 1984-12-17 |
| BE762824A (fr) | 1971-08-11 |
| NL7101847A (enrdf_load_stackoverflow) | 1971-08-16 |
| CY787A (en) | 1976-06-01 |
| FR2081505B1 (enrdf_load_stackoverflow) | 1974-08-30 |
| IL36017A0 (en) | 1971-03-24 |
| FR2081505A1 (enrdf_load_stackoverflow) | 1971-12-03 |
| MY7500060A (en) | 1975-12-31 |
| DE2106694A1 (de) | 1971-08-19 |
| SE410460B (sv) | 1979-10-15 |
| JPS5542997B1 (enrdf_load_stackoverflow) | 1980-11-04 |
| CY786A (en) | 1976-06-01 |
| CH557366A (de) | 1974-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |