GB1318050A - Indole derivatives - Google Patents
Indole derivativesInfo
- Publication number
- GB1318050A GB1318050A GB3509970A GB3509970A GB1318050A GB 1318050 A GB1318050 A GB 1318050A GB 3509970 A GB3509970 A GB 3509970A GB 3509970 A GB3509970 A GB 3509970A GB 1318050 A GB1318050 A GB 1318050A
- Authority
- GB
- United Kingdom
- Prior art keywords
- benzyloxy
- indole
- chohch
- hydroxy
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002475 indoles Chemical class 0.000 title abstract 2
- 229940054051 antipsychotic indole derivative Drugs 0.000 title 1
- SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 abstract 2
- PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 abstract 2
- RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 abstract 2
- 125000006645 (C3-C4) cycloalkyl group Chemical group 0.000 abstract 1
- 125000006201 3-phenylpropyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])C([H])([H])* 0.000 abstract 1
- -1 4-(3-substituted amino-2-hydroxypropoxy)-indole - 2 - carboxylates Chemical class 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical class ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- MDPUIQKXQCOEKH-UHFFFAOYSA-N N,N-dimethyl-1-(4-phenylmethoxy-1H-indol-2-yl)methanamine Chemical compound C(C1=CC=CC=C1)OC1=C2C=C(NC2=CC=C1)CN(C)C MDPUIQKXQCOEKH-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000005907 alkyl ester group Chemical group 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 102000012740 beta Adrenergic Receptors Human genes 0.000 abstract 1
- 108010079452 beta Adrenergic Receptors Proteins 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- DFPWFQMVPQILJP-UHFFFAOYSA-N ethyl 3-[(dimethylamino)methyl]-4-phenylmethoxy-1H-indole-2-carboxylate Chemical compound C(C)OC(=O)C=1NC2=CC=CC(=C2C1CN(C)C)OCC1=CC=CC=C1 DFPWFQMVPQILJP-UHFFFAOYSA-N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
- 230000002792 vascular Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1191869A CH514586A (de) | 1969-08-05 | 1969-08-05 | Verfahren zur Herstellung neuer Indolverbindungen |
| CH1586569 | 1969-10-24 | ||
| CH1586669 | 1969-10-24 | ||
| CH438370A CH525884A (de) | 1970-03-24 | 1970-03-24 | Verfahren zur Herstellung neuer Indolderivate |
| CH953670 | 1970-06-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1318050A true GB1318050A (en) | 1973-05-23 |
Family
ID=27509196
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3509970A Expired GB1318050A (en) | 1969-08-05 | 1970-07-20 | Indole derivatives |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3696120A (enrdf_load_html_response) |
| JP (1) | JPS5022555B1 (enrdf_load_html_response) |
| BE (1) | BE754360A (enrdf_load_html_response) |
| DE (1) | DE2038482A1 (enrdf_load_html_response) |
| FR (1) | FR2068461B1 (enrdf_load_html_response) |
| GB (1) | GB1318050A (enrdf_load_html_response) |
| PL (1) | PL81365B1 (enrdf_load_html_response) |
| SE (1) | SE369522B (enrdf_load_html_response) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU586691B2 (en) * | 1985-07-01 | 1989-07-20 | Richter Gedeon Vegyeszeti Gyar Rt. | Diamino-androstane derivatives, process for their preparation and pharmaceutical compositions containing them |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4152446A (en) * | 1974-11-16 | 1979-05-01 | Boehringer Mannheim Gmbh | Aminopropanol compounds and compositions for the treatment of cardiac and circulatory diseases |
| US4076829A (en) * | 1974-11-16 | 1978-02-28 | Boehringer Mannheim Gmbh | Aminopropanol compounds and compositions for the treatment of cardiac and circulatory diseases |
| DE2508251C2 (de) * | 1975-02-26 | 1983-12-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Derivate des Indols, Verfahren zu deren Herstellung sowie diese enthaltende Arzneimittel |
| US4340541A (en) * | 1975-08-15 | 1982-07-20 | Sandoz Ltd. | 4-(2-Benzoyloxy-3-tert.-butylaminopropoxy-2-methyl indole |
| US4235919A (en) * | 1977-07-21 | 1980-11-25 | Sandoz Ltd. | 1-(Indol-4-yloxy)-3-(2-substituted amino)-2-propanols and pharmaceutical use thereof |
| JPS54156272U (enrdf_load_html_response) * | 1978-04-24 | 1979-10-30 | ||
| JPS5746200Y2 (enrdf_load_html_response) * | 1978-06-26 | 1982-10-12 | ||
| DE3068678D1 (en) * | 1979-08-10 | 1984-08-30 | Sandoz Ag | 3-aminopropoxyaryl derivatives, their preparation and pharmaceutical compositions containing them |
| DE3115993A1 (de) * | 1981-04-13 | 1982-11-11 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Neue indol-derivate, verfahren zu ihrer herstellung und pharmazeutische praeparate, die diese verbindungen enthalten |
| US5013761A (en) * | 1988-06-03 | 1991-05-07 | Eli Lilly And Company | Serotonin antagonists |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1129072A (en) * | 1966-02-01 | 1968-10-02 | Ici Ltd | Benzofuran and indole derivatives |
| US3471515A (en) * | 1965-02-01 | 1969-10-07 | Sandoz Ag | (2-hydroxy-3-substituted aminopropoxy)indoles |
| FR353F (enrdf_load_html_response) * | 1968-06-07 | 1972-01-07 | ||
| DE1948507C2 (de) * | 1969-09-25 | 1982-10-21 | Sandoz-Patent-GmbH, 7850 Lörrach | 4-(2-Hydroxy-3-aminopropoxy)-indolderivate, ihre Salze, Verfahren zu ihrer Herstellung und Heilmittel |
-
0
- BE BE754360D patent/BE754360A/xx unknown
-
1970
- 1970-07-20 GB GB3509970A patent/GB1318050A/en not_active Expired
- 1970-07-28 US US58985A patent/US3696120A/en not_active Expired - Lifetime
- 1970-08-03 SE SE10622/70A patent/SE369522B/xx unknown
- 1970-08-03 DE DE19702038482 patent/DE2038482A1/de not_active Ceased
- 1970-08-03 PL PL1970142487A patent/PL81365B1/pl unknown
- 1970-08-04 JP JP45068283A patent/JPS5022555B1/ja active Pending
- 1970-08-04 FR FR7028683A patent/FR2068461B1/fr not_active Expired
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU586691B2 (en) * | 1985-07-01 | 1989-07-20 | Richter Gedeon Vegyeszeti Gyar Rt. | Diamino-androstane derivatives, process for their preparation and pharmaceutical compositions containing them |
Also Published As
| Publication number | Publication date |
|---|---|
| PL81365B1 (en) | 1975-08-30 |
| DE2038482A1 (de) | 1971-02-18 |
| FR2068461B1 (enrdf_load_html_response) | 1974-01-11 |
| BE754360A (fr) | 1971-02-03 |
| US3696120A (en) | 1972-10-03 |
| JPS5022555B1 (enrdf_load_html_response) | 1975-07-31 |
| SE369522B (enrdf_load_html_response) | 1974-09-02 |
| FR2068461A1 (enrdf_load_html_response) | 1971-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| 426 | Order made revoking patent and granting patent of addition in lieu thereof (sect. 26(2)/1949) | ||
| SP | Amendment (slips) printed | ||
| PCNP | Patent ceased through non-payment of renewal fee |