GB1030030A - Derivatives of phthalimide - Google Patents

Derivatives of phthalimide

Info

Publication number
GB1030030A
GB1030030A GB5253464A GB5253464A GB1030030A GB 1030030 A GB1030030 A GB 1030030A GB 5253464 A GB5253464 A GB 5253464A GB 5253464 A GB5253464 A GB 5253464A GB 1030030 A GB1030030 A GB 1030030A
Authority
GB
United Kingdom
Prior art keywords
optically active
reacting
ethyl
hydrogen
acetyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5253464A
Inventor
Raffaello Fusco
Mario Bianchi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Francesco Vismara SpA
Original Assignee
Francesco Vismara SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Francesco Vismara SpA filed Critical Francesco Vismara SpA
Priority to GB5253464A priority Critical patent/GB1030030A/en
Publication of GB1030030A publication Critical patent/GB1030030A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)

Abstract

Novel a - monosubstituted - a - phthalimidoacetamides of formula <FORM:1030030/C2/1> where R is ethyl, propyl or isopropyl, R1 is hydrogen, methyl, ethyl or acetyl, R2 is methyl or ethyl, and X is hydrogen or halogen, as racemates and optically active isomers, are prepared by reacting the corresponding phthalimido acid, either in optically active or inactive form, with an agent suitable for converting carboxyl groups to carboxylic acyl chloride groups, and reacting the phthalimidoacid chloride formed with ammonia or an amine HNR1R2, R1 and R2 being as defined in Claim 1 except that R1 is not acetyl, and treating, if desired, the resulting phthalimidoacetamide when R1 is hydrogen with acetic anhydride to obtain the N-acetyl derivative. The optically active phthalimidiacids can be obtained by optical resolution of the corresponding racemic acid, e.g. by fractional crystallization of its ephedrine salts, or by reacting the appropriate phthalic anhydride with an optically active a -amino-acid of formula RCH(NH2)COOH. Therapeutic compositions which are useful as tranquilizers and anticonvulsants and which may be administered orally, e.g. as tablets, pills, wafers, or cachets, contain as active ingredient the compounds described above.
GB5253464A 1964-12-28 1964-12-28 Derivatives of phthalimide Expired GB1030030A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB5253464A GB1030030A (en) 1964-12-28 1964-12-28 Derivatives of phthalimide

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB5253464A GB1030030A (en) 1964-12-28 1964-12-28 Derivatives of phthalimide

Publications (1)

Publication Number Publication Date
GB1030030A true GB1030030A (en) 1966-05-18

Family

ID=10464276

Family Applications (1)

Application Number Title Priority Date Filing Date
GB5253464A Expired GB1030030A (en) 1964-12-28 1964-12-28 Derivatives of phthalimide

Country Status (1)

Country Link
GB (1) GB1030030A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995001348A2 (en) * 1993-07-02 1995-01-12 Celgene Corporation Imides as inhibitors of tnp alpha

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995001348A2 (en) * 1993-07-02 1995-01-12 Celgene Corporation Imides as inhibitors of tnp alpha
WO1995001348A3 (en) * 1993-07-02 1995-03-09 Celgene Corp Imides as inhibitors of tnp alpha
EP1477486A3 (en) * 1993-07-02 2004-12-15 Celgene Corporation Imides as inhibitors of TNF alpha

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