GB1307005A - Pyrazole derivatives - Google Patents
Pyrazole derivativesInfo
- Publication number
- GB1307005A GB1307005A GB4314770A GB4314770A GB1307005A GB 1307005 A GB1307005 A GB 1307005A GB 4314770 A GB4314770 A GB 4314770A GB 4314770 A GB4314770 A GB 4314770A GB 1307005 A GB1307005 A GB 1307005A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hydrolysing
- reacting
- alkyl
- dimethyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003217 pyrazoles Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 230000003301 hydrolyzing effect Effects 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000002148 esters Chemical class 0.000 abstract 2
- -1 pyrrolidino, piperidino Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 1
- LRGBDJBDJXZTTD-UHFFFAOYSA-N 1h-pyrazole-4-carbaldehyde Chemical compound O=CC=1C=NNC=1 LRGBDJBDJXZTTD-UHFFFAOYSA-N 0.000 abstract 1
- PXWJTOHJADWQQO-UHFFFAOYSA-N 2-(1h-pyrazol-4-yl)acetic acid Chemical class OC(=O)CC=1C=NNC=1 PXWJTOHJADWQQO-UHFFFAOYSA-N 0.000 abstract 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- CSRWSPHRKUSDRE-UHFFFAOYSA-N 4-(chloromethyl)-1h-pyrazole Chemical compound ClCC=1C=NNC=1 CSRWSPHRKUSDRE-UHFFFAOYSA-N 0.000 abstract 1
- JRMKJOOJKCAEJK-UHFFFAOYSA-N 4-Hydroxymethylpyrazole Chemical compound OCC=1C=NNC=1 JRMKJOOJKCAEJK-UHFFFAOYSA-N 0.000 abstract 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000001741 anti-phlogistic effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000007795 chemical reaction product Substances 0.000 abstract 1
- PQLFTVZASJMHTA-UHFFFAOYSA-N ethyl 2-(3,5-dimethyl-1-phenylpyrazol-4-yl)ethanimidate Chemical compound CC1=NN(C(=C1CC(OCC)=N)C)C1=CC=CC=C1 PQLFTVZASJMHTA-UHFFFAOYSA-N 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 125000004573 morpholin-4-yl group Chemical group N1(CCOCC1)* 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 239000000047 product Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/455—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation with carboxylic acids or their derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
- C07C49/792—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1946370A DE1946370C3 (de) | 1969-09-12 | 1969-09-12 | Substituierte Pyrazol-4-essigsäuren, Verfahren zu ihrer Herstellung und sie enthaltende Arzneimittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1307005A true GB1307005A (en) | 1973-02-14 |
Family
ID=5745381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4314770A Expired GB1307005A (en) | 1969-09-12 | 1970-09-09 | Pyrazole derivatives |
Country Status (13)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4146721A (en) * | 1969-09-12 | 1979-03-27 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pyrazol-4-acetic acid compounds |
| GB1373212A (en) * | 1970-12-07 | 1974-11-06 | Wyeth John & Brother Ltd | Pyrazole compounds |
| US3984431A (en) * | 1972-03-15 | 1976-10-05 | Claude Gueremy | Derivatives of pyrazole-5-acetic acid |
| US4042702A (en) | 1973-08-16 | 1977-08-16 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Halogen pyrazole derivatives, a method for producing these halogen pyrazole derivatives, medicaments containing and methods of using them |
| DK115374A (enrdf_load_stackoverflow) | 1974-03-04 | 1975-11-03 | Byk Gulden Lomberg Chem Fab | |
| DE2536003C2 (de) * | 1975-08-08 | 1985-11-14 | Schering AG, 1000 Berlin und 4709 Bergkamen | Pyrazol-Derivate, ihre Herstellung und diese enthaltende pharmazeutische Derivate |
| DE2633992A1 (de) * | 1975-08-08 | 1978-02-09 | Schering Ag | Neue pyrazol-derivate, ihre herstellung und verwendung |
| DE2906252A1 (de) * | 1979-02-19 | 1980-08-28 | Merck Patent Gmbh | Pyrazolderivate, diese enthaltende pharmazeutische zubereitungen und verfahren zu ihrer herstellung |
| US4826868A (en) * | 1986-05-29 | 1989-05-02 | Ortho Pharmaceutical Corporation | 1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use |
| AU611437B2 (en) * | 1987-05-29 | 1991-06-13 | Ortho Pharmaceutical Corporation | Pharmacologically active 2- and 3-substituted (1',5'-diaryl-3-pyrazolyl)-n-hydroxypropanamides and method for synthesizing the same |
| JPS63307841A (ja) * | 1987-05-29 | 1988-12-15 | オーソ・フアーマシユーチカル・コーポレーシヨン | １，５‐ジ置換ピラゾール類の製造法 |
| US5466823A (en) | 1993-11-30 | 1995-11-14 | G.D. Searle & Co. | Substituted pyrazolyl benzenesulfonamides |
| DE10152005A1 (de) | 2001-10-22 | 2003-04-30 | Bayer Cropscience Ag | Pyrazolylsubstituierte Heterocyclen |
| DE10331675A1 (de) | 2003-07-14 | 2005-02-10 | Bayer Cropscience Ag | Hetarylsubstituierte Pyrazolidindion-Derivate |
| EP2135865A1 (de) | 2008-06-17 | 2009-12-23 | Bayer CropScience AG | Substituierte 1-(Diazinyl) pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| EP2194052A1 (de) | 2008-12-06 | 2010-06-09 | Bayer CropScience AG | Substituierte 1-(Thiazolyl)- und 1-(Isothiazolyl)pyrazol-4-yl-essigsäuren, Verfahren zu deren Herstellung und deren Verwendung als Herbizide und Pflanzenwachstumsregulatoren |
| WO2011073098A1 (de) | 2009-12-15 | 2011-06-23 | Bayer Cropscience Ag | 1-(heteroaryl)-pyrazol-4-yl-essigsäuren, verfahren zu deren herstellung und deren verwendung als herbizide und pflanzenwachstumsregulatoren |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1182412A (fr) * | 1956-08-03 | 1959-06-25 | Geigy Ag J R | Nouveaux acides carboxyliques hétérocycliques de la série du pyrazole ainsi que leurs esters et leurs sels et la préparation de ces composés |
-
0
- BE BE755924D patent/BE755924A/xx not_active IP Right Cessation
-
1969
- 1969-09-12 DE DE1946370A patent/DE1946370C3/de not_active Expired
-
1970
- 1970-08-28 CH CH346073A patent/CH583707A5/xx not_active IP Right Cessation
- 1970-08-28 CH CH1290470A patent/CH587251A5/xx not_active IP Right Cessation
- 1970-09-09 GB GB4314770A patent/GB1307005A/en not_active Expired
- 1970-09-10 CA CA092,873A patent/CA959838A/en not_active Expired
- 1970-09-10 IE IE1175/70A patent/IE35377B1/xx unknown
- 1970-09-10 SE SE7012345A patent/SE385212B/xx unknown
- 1970-09-10 NL NL7013384A patent/NL7013384A/xx unknown
- 1970-09-11 FR FR7033102A patent/FR2070689B1/fr not_active Expired
- 1970-09-11 AT AT188472A patent/AT313274B/de active
- 1970-09-11 ZA ZA706215A patent/ZA706215B/xx unknown
- 1970-09-11 JP JP45079421A patent/JPS5133906B1/ja active Pending
- 1970-09-11 AT AT826170A patent/AT304534B/de not_active IP Right Cessation
-
1974
- 1974-06-05 JP JP6298874A patent/JPS5339435B1/ja active Pending
-
1978
- 1978-05-04 HK HK235/78A patent/HK23578A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA706215B (en) | 1971-05-27 |
| IE35377B1 (en) | 1976-02-04 |
| NL7013384A (enrdf_load_stackoverflow) | 1971-03-16 |
| HK23578A (en) | 1978-05-12 |
| SE385212B (sv) | 1976-06-14 |
| BE755924A (fr) | 1971-02-15 |
| FR2070689B1 (enrdf_load_stackoverflow) | 1974-08-30 |
| JPS5339435B1 (enrdf_load_stackoverflow) | 1978-10-21 |
| CA959838A (en) | 1974-12-24 |
| DE1946370B2 (de) | 1978-11-09 |
| AT313274B (de) | 1974-02-11 |
| JPS5133906B1 (enrdf_load_stackoverflow) | 1976-09-22 |
| FR2070689A1 (enrdf_load_stackoverflow) | 1971-09-17 |
| DE1946370A1 (de) | 1971-04-22 |
| DE1946370C3 (de) | 1979-07-26 |
| CH587251A5 (enrdf_load_stackoverflow) | 1977-04-29 |
| AT304534B (de) | 1973-01-10 |
| CH583707A5 (enrdf_load_stackoverflow) | 1977-01-14 |
| IE35377L (en) | 1971-03-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| 429A | Application made for amendment of specification (sect. 29/1949) | ||
| 429H | Application (made) for amendment of specification now open to opposition (sect. 29/1949) | ||
| 429D | Case decided by the comptroller ** specification amended (sect. 29/1949) | ||
| SPA | Amended specification published | ||
| PE20 | Patent expired after termination of 20 years |