GB1257956A - - Google Patents
Info
- Publication number
- GB1257956A GB1257956A GB1257956DA GB1257956A GB 1257956 A GB1257956 A GB 1257956A GB 1257956D A GB1257956D A GB 1257956DA GB 1257956 A GB1257956 A GB 1257956A
- Authority
- GB
- United Kingdom
- Prior art keywords
- weight
- polyhydroxyphenylchromones
- silymarin
- give
- subjected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 abstract 2
- SEBFKMXJBCUCAI-HKTJVKLFSA-N silibinin Chemical compound C1=C(O)C(OC)=CC([C@@H]2[C@H](OC3=CC=C(C=C3O2)[C@@H]2[C@H](C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-HKTJVKLFSA-N 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- SEBFKMXJBCUCAI-UHFFFAOYSA-N NSC 227190 Natural products C1=C(O)C(OC)=CC(C2C(OC3=CC=C(C=C3O2)C2C(C(=O)C3=C(O)C=C(O)C=C3O2)O)CO)=C1 SEBFKMXJBCUCAI-UHFFFAOYSA-N 0.000 abstract 1
- 244000272459 Silybum marianum Species 0.000 abstract 1
- 235000010841 Silybum marianum Nutrition 0.000 abstract 1
- 239000011149 active material Substances 0.000 abstract 1
- 239000003610 charcoal Substances 0.000 abstract 1
- 235000011869 dried fruits Nutrition 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000010685 fatty oil Substances 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
- 239000002245 particle Substances 0.000 abstract 1
- 238000005192 partition Methods 0.000 abstract 1
- 239000008024 pharmaceutical diluent Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 229960004245 silymarin Drugs 0.000 abstract 1
- 235000017700 silymarin Nutrition 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 239000011343 solid material Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
- C07D311/40—Separation, e.g. from natural material; Purification
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Microbiology (AREA)
- Pharmacology & Pharmacy (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Biotechnology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19681767666 DE1767666C3 (de) | 1968-06-01 | 1968-06-01 | Pharmazeutische Zubereitung gegen Lebererkrankungen |
| DE1923082A DE1923082C3 (de) | 1969-05-06 | 1969-05-06 | Verfahren zur Gewinnung von Polyhydroxyphenylchromanonen (Silymarin I-IV) und Arzneimittel enthaltend das Polyhydroxyphenylchromanon (Silymarin I-IV = Silymarin I-IV-Gruppe)Gemisch |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1257956A true GB1257956A (enrdf_load_stackoverflow) | 1971-12-22 |
Family
ID=25755470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1257956D Expired GB1257956A (enrdf_load_stackoverflow) | 1968-06-01 | 1969-05-30 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3773932A (enrdf_load_stackoverflow) |
| BE (1) | BE733911A (enrdf_load_stackoverflow) |
| CA (1) | CA1029735A (enrdf_load_stackoverflow) |
| FR (1) | FR2010026A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1257956A (enrdf_load_stackoverflow) |
| LU (1) | LU58751A1 (enrdf_load_stackoverflow) |
| NL (1) | NL6908301A (enrdf_load_stackoverflow) |
| OA (1) | OA03888A (enrdf_load_stackoverflow) |
| SE (1) | SE371931B (enrdf_load_stackoverflow) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2020407A1 (de) * | 1970-04-27 | 1971-11-11 | Bernhard Dr Janiak | Technisches Verfahren zur Isolierung von Silimarin |
| DE2914330A1 (de) * | 1979-04-09 | 1980-10-30 | Madaus & Co Dr | Verfahren zur gewinnung von silymarin aus pflanzen |
| DE3537656A1 (de) * | 1984-11-22 | 1986-05-22 | Dr. Madaus GmbH & Co, 5000 Köln | Verfahren zur herstellung von isosilybinfreiem silibinin und arzneimittel, enthaltend silibinin |
| HRP20020858A2 (en) * | 2002-10-29 | 2005-02-28 | Leko Vladimir | Method for isolation of sylimarin from sylibum marianum seeds |
| CA2761656C (en) | 2009-05-14 | 2017-02-07 | Lucio Claudio Rovati | Amorphous silibinin for the treatment of viral hepatitis |
-
1969
- 1969-05-27 US US00828353A patent/US3773932A/en not_active Expired - Lifetime
- 1969-05-29 CA CA053,025A patent/CA1029735A/en not_active Expired
- 1969-05-30 BE BE733911D patent/BE733911A/xx not_active IP Right Cessation
- 1969-05-30 NL NL6908301A patent/NL6908301A/xx unknown
- 1969-05-30 LU LU58751D patent/LU58751A1/xx unknown
- 1969-05-30 GB GB1257956D patent/GB1257956A/en not_active Expired
- 1969-05-30 SE SE6907652*A patent/SE371931B/xx unknown
- 1969-06-02 OA OA53625A patent/OA03888A/xx unknown
- 1969-06-02 FR FR6918088A patent/FR2010026A1/fr active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| FR2010026A1 (enrdf_load_stackoverflow) | 1970-02-13 |
| SE371931B (enrdf_load_stackoverflow) | 1974-12-09 |
| OA03888A (fr) | 1975-08-14 |
| CA1029735A (en) | 1978-04-18 |
| BE733911A (enrdf_load_stackoverflow) | 1969-11-03 |
| NL6908301A (enrdf_load_stackoverflow) | 1969-12-03 |
| LU58751A1 (enrdf_load_stackoverflow) | 1969-09-15 |
| US3773932A (en) | 1973-11-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE20 | Patent expired after termination of 20 years |