GB1241263A - Butyl-piperazine derivatives and process for their preparation - Google Patents
Butyl-piperazine derivatives and process for their preparationInfo
- Publication number
- GB1241263A GB1241263A GB53482/69A GB5348269A GB1241263A GB 1241263 A GB1241263 A GB 1241263A GB 53482/69 A GB53482/69 A GB 53482/69A GB 5348269 A GB5348269 A GB 5348269A GB 1241263 A GB1241263 A GB 1241263A
- Authority
- GB
- United Kingdom
- Prior art keywords
- fluorophenyl
- piperazine derivatives
- piperazin
- addition salts
- physiologically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- YKSVXVKIYYQWBB-UHFFFAOYSA-N 1-butylpiperazine Chemical class CCCCN1CCNCC1 YKSVXVKIYYQWBB-UHFFFAOYSA-N 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 3
- 150000004885 piperazines Chemical class 0.000 abstract 3
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 abstract 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 2
- WTDHULULXKLSOZ-UHFFFAOYSA-N Hydroxylamine hydrochloride Chemical compound Cl.ON WTDHULULXKLSOZ-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- BGJSXRVXTHVRSN-UHFFFAOYSA-N 1,3,5-trioxane Chemical group C1OCOCO1 BGJSXRVXTHVRSN-UHFFFAOYSA-N 0.000 abstract 1
- AVJKDKWRVSSJPK-UHFFFAOYSA-N 1-(4-fluorophenyl)piperazine Chemical compound C1=CC(F)=CC=C1N1CCNCC1 AVJKDKWRVSSJPK-UHFFFAOYSA-N 0.000 abstract 1
- ZBVOLUTWLMZUGY-UHFFFAOYSA-N 4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-amine Chemical compound C1CN(CCC(N)C)CCN1C1=CC=C(F)C=C1 ZBVOLUTWLMZUGY-UHFFFAOYSA-N 0.000 abstract 1
- IVTQRSPPLVLOMK-UHFFFAOYSA-N 4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-one Chemical compound C1CN(CCC(=O)C)CCN1C1=CC=C(F)C=C1 IVTQRSPPLVLOMK-UHFFFAOYSA-N 0.000 abstract 1
- PZILJUBNRIIIGA-UHFFFAOYSA-N N-[4-[4-(4-fluorophenyl)piperazin-1-yl]butan-2-ylidene]hydroxylamine Chemical compound FC1=CC=C(C=C1)N1CCN(CC1)CCC(C)=NO PZILJUBNRIIIGA-UHFFFAOYSA-N 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000000954 anitussive effect Effects 0.000 abstract 1
- 230000001387 anti-histamine Effects 0.000 abstract 1
- 239000000739 antihistaminic agent Substances 0.000 abstract 1
- 229940124584 antitussives Drugs 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 125000002837 carbocyclic group Chemical group 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 150000001805 chlorine compounds Chemical class 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- PCHPORCSPXIHLZ-UHFFFAOYSA-N diphenhydramine hydrochloride Chemical compound [Cl-].C=1C=CC=CC=1C(OCC[NH+](C)C)C1=CC=CC=C1 PCHPORCSPXIHLZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- BHRZNVHARXXAHW-UHFFFAOYSA-N sec-butylamine Chemical class CCC(C)N BHRZNVHARXXAHW-UHFFFAOYSA-N 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/125—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/13—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR75173685A FR8436M (cs) | 1968-11-14 | 1968-11-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1241263A true GB1241263A (en) | 1971-08-04 |
Family
ID=8656850
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB53482/69A Expired GB1241263A (en) | 1968-11-14 | 1969-10-31 | Butyl-piperazine derivatives and process for their preparation |
Country Status (8)
| Country | Link |
|---|---|
| AT (1) | AT294102B (cs) |
| BE (1) | BE741358A (cs) |
| BR (1) | BR6914105D0 (cs) |
| CH (1) | CH500994A (cs) |
| DE (1) | DE1957371C3 (cs) |
| ES (1) | ES373416A1 (cs) |
| FR (1) | FR8436M (cs) |
| GB (1) | GB1241263A (cs) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0113226A1 (en) * | 1982-12-24 | 1984-07-11 | Fujisawa Pharmaceutical Co., Ltd. | Benzhydrylpiperazine derivatives, processes for the preparation thereof and pharmaceutical compositions comprising the same |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4766125A (en) * | 1981-06-23 | 1988-08-23 | Janssen Pharmaceutica N.V. | N-aryl-piperazinealkanamides useful for protecting hearts from myocardial injury caused by ischaemia, anoxia or hypoxia |
-
1968
- 1968-11-14 FR FR75173685A patent/FR8436M/fr not_active Expired
-
1969
- 1969-10-31 GB GB53482/69A patent/GB1241263A/en not_active Expired
- 1969-11-05 CH CH1664169A patent/CH500994A/fr not_active IP Right Cessation
- 1969-11-06 BE BE741358D patent/BE741358A/xx unknown
- 1969-11-11 ES ES373416A patent/ES373416A1/es not_active Expired
- 1969-11-12 BR BR21410569A patent/BR6914105D0/pt unknown
- 1969-11-12 AT AT1061169A patent/AT294102B/de not_active IP Right Cessation
- 1969-11-14 DE DE19691957371 patent/DE1957371C3/de not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0113226A1 (en) * | 1982-12-24 | 1984-07-11 | Fujisawa Pharmaceutical Co., Ltd. | Benzhydrylpiperazine derivatives, processes for the preparation thereof and pharmaceutical compositions comprising the same |
| US4591590A (en) * | 1982-12-24 | 1986-05-27 | Fujisawa Pharmaceutical Co., Ltd. | Benzhydrylpiperazine derivatives, processes for the preparation thereof and pharmaceutical composition comprising the same |
Also Published As
| Publication number | Publication date |
|---|---|
| CH500994A (fr) | 1970-12-31 |
| DE1957371C3 (de) | 1975-05-15 |
| BR6914105D0 (pt) | 1973-02-13 |
| DE1957371A1 (de) | 1970-05-21 |
| ES373416A1 (es) | 1972-07-01 |
| BE741358A (cs) | 1970-04-16 |
| AT294102B (de) | 1971-11-10 |
| DE1957371B2 (de) | 1974-09-12 |
| FR8436M (cs) | 1971-07-15 |
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