GB1228848A - - Google Patents
Info
- Publication number
- GB1228848A GB1228848A GB1228848DA GB1228848A GB 1228848 A GB1228848 A GB 1228848A GB 1228848D A GB1228848D A GB 1228848DA GB 1228848 A GB1228848 A GB 1228848A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acid
- hydrazines
- formula
- acyl
- dec
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- JOOXCMJARBKPKM-UHFFFAOYSA-N 4-oxopentanoic acid Chemical compound CC(=O)CCC(O)=O JOOXCMJARBKPKM-UHFFFAOYSA-N 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 238000005917 acylation reaction Methods 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 238000009833 condensation Methods 0.000 abstract 2
- 230000005494 condensation Effects 0.000 abstract 2
- 150000002429 hydrazines Chemical class 0.000 abstract 2
- 229940040102 levulinic acid Drugs 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- QOPBEBWGSGFROG-UHFFFAOYSA-N 2-(1h-indol-2-yl)acetic acid Chemical class C1=CC=C2NC(CC(=O)O)=CC2=C1 QOPBEBWGSGFROG-UHFFFAOYSA-N 0.000 abstract 1
- NGNBDVOYPDDBFK-UHFFFAOYSA-N 2-[2,4-di(pentan-2-yl)phenoxy]acetyl chloride Chemical compound CCCC(C)C1=CC=C(OCC(Cl)=O)C(C(C)CCC)=C1 NGNBDVOYPDDBFK-UHFFFAOYSA-N 0.000 abstract 1
- 125000002373 5 membered heterocyclic group Chemical group 0.000 abstract 1
- 125000004070 6 membered heterocyclic group Chemical group 0.000 abstract 1
- 235000011054 acetic acid Nutrition 0.000 abstract 1
- 150000008065 acid anhydrides Chemical class 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000000068 chlorophenyl group Chemical group 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 150000007522 mineralic acids Chemical class 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- -1 quinaldinyl group Chemical group 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 150000003512 tertiary amines Chemical class 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
- C07D209/28—1-(4-Chlorobenzoyl)-2-methyl-indolyl-3-acetic acid, substituted in position 5 by an oxygen or nitrogen atom; Esters thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PL124321A PL62464B1 (enrdf_load_stackoverflow) | 1967-12-27 | ||
| PL127148A PL65769B1 (enrdf_load_stackoverflow) | 1968-05-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1228848A true GB1228848A (enrdf_load_stackoverflow) | 1971-04-21 |
Family
ID=26652821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1228848D Expired GB1228848A (enrdf_load_stackoverflow) | 1967-12-27 | 1968-12-30 |
Country Status (10)
| Country | Link |
|---|---|
| CH (1) | CH498831A (enrdf_load_stackoverflow) |
| CS (1) | CS162665B2 (enrdf_load_stackoverflow) |
| DE (1) | DE1816993C3 (enrdf_load_stackoverflow) |
| DK (1) | DK136033B (enrdf_load_stackoverflow) |
| FR (1) | FR1599484A (enrdf_load_stackoverflow) |
| GB (1) | GB1228848A (enrdf_load_stackoverflow) |
| NL (1) | NL6818723A (enrdf_load_stackoverflow) |
| RO (1) | RO55545A (enrdf_load_stackoverflow) |
| SE (1) | SE350494B (enrdf_load_stackoverflow) |
| YU (1) | YU311968A (enrdf_load_stackoverflow) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1992006088A1 (en) * | 1990-10-03 | 1992-04-16 | Pfizer Inc. | Indole derivatives as antiallergy and antiinflammatory agents |
| US5190968A (en) * | 1991-09-30 | 1993-03-02 | Merck Frosst Canada, Inc. | (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
| US5204344A (en) * | 1989-08-22 | 1993-04-20 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
| US5272145A (en) * | 1989-08-22 | 1993-12-21 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
| US5290798A (en) * | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5308850A (en) * | 1991-09-30 | 1994-05-03 | Merck Frosst Canada, Inc. | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5374635A (en) * | 1993-03-29 | 1994-12-20 | Merck Frosst Canada, Inc. | Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of leukotriene biosynthesis |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT95692A (pt) * | 1989-10-27 | 1991-09-13 | American Home Prod | Processo para a preparacao de derivados de acidos indole-,indeno-,piranoindole- e tetra-hidrocarbazole-alcanoicos, ou quais sao uteis como inibidores de pla2 e da lipoxigenase |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT262993B (de) * | 1965-04-19 | 1968-07-10 | Sumitomo Chemical Co | Verfahren zur Herstellung von zum Teil neuen aliphatischen (3-Indolyl)-carbonsäuren bzw. von funktionellen Derivaten derselben |
-
1968
- 1968-12-19 DK DK622768A patent/DK136033B/da unknown
- 1968-12-19 CH CH1897968A patent/CH498831A/fr not_active IP Right Cessation
- 1968-12-20 CS CS868268A patent/CS162665B2/cs unknown
- 1968-12-20 SE SE1765268A patent/SE350494B/xx unknown
- 1968-12-24 DE DE19681816993 patent/DE1816993C3/de not_active Expired
- 1968-12-26 RO RO5863568A patent/RO55545A/ro unknown
- 1968-12-27 NL NL6818723A patent/NL6818723A/xx not_active Application Discontinuation
- 1968-12-27 YU YU311968A patent/YU311968A/xx unknown
- 1968-12-27 FR FR1599484D patent/FR1599484A/fr not_active Expired
- 1968-12-30 GB GB1228848D patent/GB1228848A/en not_active Expired
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5204344A (en) * | 1989-08-22 | 1993-04-20 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
| US5272145A (en) * | 1989-08-22 | 1993-12-21 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
| US5380850A (en) * | 1989-08-22 | 1995-01-10 | Merck Frosst Canada, Inc. | (Quinolin-2-ylmethoxy)indoles as inhibitors of the biosynthesis of leukotrienes |
| WO1992006088A1 (en) * | 1990-10-03 | 1992-04-16 | Pfizer Inc. | Indole derivatives as antiallergy and antiinflammatory agents |
| US5290788A (en) * | 1990-10-03 | 1994-03-01 | Pfizer Inc. | Indole derivatives as antiallergy and antiinflammatory agents |
| US5190968A (en) * | 1991-09-30 | 1993-03-02 | Merck Frosst Canada, Inc. | (Polycyclic-arylmethoxy) indoles as inhibitors of leukotriene biosynthesis |
| US5290798A (en) * | 1991-09-30 | 1994-03-01 | Merck Frosst Canada, Inc. | (hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5308850A (en) * | 1991-09-30 | 1994-05-03 | Merck Frosst Canada, Inc. | (Bicyclic-hetero-arylmethoxy)indoles as inhibitors of leukotriene biosynthesis |
| US5374635A (en) * | 1993-03-29 | 1994-12-20 | Merck Frosst Canada, Inc. | Furo[3,2-b]pyridines and thieno[3,2-b]pyridines as inhibitors of leukotriene biosynthesis |
Also Published As
| Publication number | Publication date |
|---|---|
| DE1816993A1 (de) | 1969-10-16 |
| DE1816993B2 (de) | 1973-08-09 |
| YU311968A (en) | 1973-12-31 |
| DK136033B (da) | 1977-08-01 |
| FR1599484A (enrdf_load_stackoverflow) | 1970-07-15 |
| SE350494B (enrdf_load_stackoverflow) | 1972-10-30 |
| DE1816993C3 (de) | 1982-05-06 |
| CH498831A (fr) | 1970-11-15 |
| NL6818723A (enrdf_load_stackoverflow) | 1969-07-01 |
| RO55545A (enrdf_load_stackoverflow) | 1974-04-01 |
| CS162665B2 (enrdf_load_stackoverflow) | 1975-07-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |