GB1209669A - New isoquinaldic acid derivatives, and processes for preparing them - Google Patents

New isoquinaldic acid derivatives, and processes for preparing them

Info

Publication number
GB1209669A
GB1209669A GB8261/70A GB826170A GB1209669A GB 1209669 A GB1209669 A GB 1209669A GB 8261/70 A GB8261/70 A GB 8261/70A GB 826170 A GB826170 A GB 826170A GB 1209669 A GB1209669 A GB 1209669A
Authority
GB
United Kingdom
Prior art keywords
acid
isoquinaldic
methyl
prepared
tetrahydroisoquinaldic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB8261/70A
Other languages
English (en)
Inventor
Daniel Bertin
Andre Pierdet
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
Original Assignee
Roussel Uclaf SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Roussel Uclaf SA filed Critical Roussel Uclaf SA
Publication of GB1209669A publication Critical patent/GB1209669A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB8261/70A 1967-03-29 1968-03-29 New isoquinaldic acid derivatives, and processes for preparing them Expired GB1209669A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR100617A FR1525186A (fr) 1967-03-29 1967-03-29 Nouvelles pénicillines et procédé de préparation
FR138141A FR7155M (https=) 1967-03-29 1968-01-31

Publications (1)

Publication Number Publication Date
GB1209669A true GB1209669A (en) 1970-10-21

Family

ID=26175147

Family Applications (2)

Application Number Title Priority Date Filing Date
GB8261/70A Expired GB1209669A (en) 1967-03-29 1968-03-29 New isoquinaldic acid derivatives, and processes for preparing them
GB05424/68A Expired GB1209668A (en) 1967-03-29 1968-03-29 New penicillins and processes for preparing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB05424/68A Expired GB1209668A (en) 1967-03-29 1968-03-29 New penicillins and processes for preparing them

Country Status (8)

Country Link
US (1) US3494917A (https=)
CH (1) CH491958A (https=)
DE (1) DE1770062C3 (https=)
DK (1) DK118021B (https=)
FR (2) FR1525186A (https=)
GB (2) GB1209669A (https=)
IL (1) IL29661A (https=)
NL (1) NL144944B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753952A (en) * 1985-12-23 1988-06-28 Dr. Lo. Zambeletti S.P.A. 2-acyl-3-aminomethyl-1,2,3,4-tetrahydroquinolines
WO1993012091A1 (en) * 1991-12-19 1993-06-24 Gyógyszerkutató Intézet Kft. D- and l-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acids and their derivatives containing urethane-type n-protecting groups as well as a process for preparing them and the corresponding racemates

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101937514B1 (ko) 2011-10-14 2019-01-10 브리스톨-마이어스 스큅 컴퍼니 인자 xia 억제제로서의 치환된 테트라히드로이소퀴놀린 화합물
ES2579832T3 (es) 2011-10-14 2016-08-17 Bristol-Myers Squibb Company Compuestos de tetrahidroisoquinolina sustituida como inhibidores del factor XIa
EP2766345B1 (en) 2011-10-14 2016-03-16 Bristol-Myers Squibb Company Substituted tetrahydroisoquinoline compounds as factor xia inhibitors
TR201807316T4 (tr) 2012-10-12 2018-06-21 Bristol Myers Squibb Co Bir faktör XIa inhibitörünün kristalli formları.
WO2014059214A1 (en) 2012-10-12 2014-04-17 Bristol-Myers Squibb Company Guanidine and amine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
EP2906552B1 (en) 2012-10-12 2017-11-22 Bristol-Myers Squibb Company Guanidine substituted tetrahydroisoquinoline compounds as factor xia inhibitors
ES2712699T3 (es) 2013-03-25 2019-05-14 Bristol Myers Squibb Co Tetrahidroisoquinolinas que contienen azoles sustituidos como inhibidores del factor XIa
CN116987080A (zh) 2014-01-31 2023-11-03 百时美施贵宝公司 作为因子xia抑制剂的具有杂环p2′基团的大环化合物
NO2760821T3 (https=) 2014-01-31 2018-03-10
CN107074821B (zh) 2014-09-04 2020-05-22 百时美施贵宝公司 为fxia抑制剂的二酰胺大环化合物
US9453018B2 (en) 2014-10-01 2016-09-27 Bristol-Myers Squibb Company Pyrimidinones as factor XIa inhibitors

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3174964A (en) * 1959-12-10 1965-03-23 Pfizer & Co C Derivatives of 6-aminopenicillanic acid
US3043831A (en) * 1960-07-18 1962-07-10 Doyle Frank Peter Synthetic penicillins

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4753952A (en) * 1985-12-23 1988-06-28 Dr. Lo. Zambeletti S.P.A. 2-acyl-3-aminomethyl-1,2,3,4-tetrahydroquinolines
EP0228246B1 (en) * 1985-12-23 1991-03-06 Dr. Lo. Zambeletti S.p.A. Isoquinoline compounds
WO1993012091A1 (en) * 1991-12-19 1993-06-24 Gyógyszerkutató Intézet Kft. D- and l-1,2,3,4-tetrahydro-isoquinoline-1-carboxylic acids and their derivatives containing urethane-type n-protecting groups as well as a process for preparing them and the corresponding racemates

Also Published As

Publication number Publication date
NL6804392A (https=) 1968-09-30
GB1209668A (en) 1970-10-21
DE1770062C3 (de) 1979-08-02
DE1770062A1 (de) 1971-09-16
DE1770062B2 (de) 1978-11-30
NL144944B (nl) 1975-02-17
US3494917A (en) 1970-02-10
DK118021B (da) 1970-06-29
FR7155M (https=) 1969-08-04
FR1525186A (fr) 1968-05-17
IL29661A (en) 1972-01-27
CH491958A (fr) 1970-06-15

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee