GB1206915A - 3-substituted-1-indole-lower-alkanoic acids and esters and derivatives thereof - Google Patents

3-substituted-1-indole-lower-alkanoic acids and esters and derivatives thereof

Info

Publication number
GB1206915A
GB1206915A GB7719/69A GB771969A GB1206915A GB 1206915 A GB1206915 A GB 1206915A GB 7719/69 A GB7719/69 A GB 7719/69A GB 771969 A GB771969 A GB 771969A GB 1206915 A GB1206915 A GB 1206915A
Authority
GB
United Kingdom
Prior art keywords
alkyl
derivatives
esters
prepared
indole
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB7719/69A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sterling Drug Inc filed Critical Sterling Drug Inc
Publication of GB1206915A publication Critical patent/GB1206915A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/36—Oxygen atoms in position 3, e.g. adrenochrome

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB7719/69A 1968-02-20 1969-02-12 3-substituted-1-indole-lower-alkanoic acids and esters and derivatives thereof Expired GB1206915A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US70680268A 1968-02-20 1968-02-20

Publications (1)

Publication Number Publication Date
GB1206915A true GB1206915A (en) 1970-09-30

Family

ID=24839099

Family Applications (1)

Application Number Title Priority Date Filing Date
GB7719/69A Expired GB1206915A (en) 1968-02-20 1969-02-12 3-substituted-1-indole-lower-alkanoic acids and esters and derivatives thereof

Country Status (10)

Country Link
US (2) US3557142A (enExample)
JP (1) JPS4843740B1 (enExample)
BE (1) BE728675A (enExample)
BR (1) BR6906477D0 (enExample)
CH (1) CH507238A (enExample)
DE (1) DE1908541A1 (enExample)
FR (1) FR2002284B1 (enExample)
GB (1) GB1206915A (enExample)
NL (1) NL6902641A (enExample)
SE (1) SE350259B (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2457040A (en) * 2008-01-30 2009-08-05 Oxagen Ltd 1-Acetic acid indole derivatives with PGD2 activity
US8168673B2 (en) 2008-01-22 2012-05-01 Oxagen Limited Compounds having CRTH2 antagonist activity

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FR7337M (enExample) * 1968-01-11 1969-10-13
FR2096868B1 (enExample) * 1970-07-08 1974-02-01 Roussel Uclaf
GB1318300A (en) * 1970-12-09 1973-05-23 Labaz Indole derivatives nad compositions containing the same
GB1436771A (en) * 1973-02-16 1976-05-26 Labaz Indole derivatives and process for preparing the same
US4021448A (en) * 1975-10-21 1977-05-03 Sterling Drug Inc. 2-Substituted-indole-1-lower-alkanecarboxamides
US4233312A (en) * 1976-01-21 1980-11-11 Roussel Uclaf Esters of indole-1-acetic acid and analgesic use thereof
SE421917B (sv) * 1976-01-21 1982-02-08 Roussel Uclaf Analogiforfarande for framstellning av nya derivat av 2-metyl-1-indolyl-ettikssyra med terapeutisk verkan
US4460777A (en) * 1981-11-19 1984-07-17 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4478842A (en) * 1981-11-19 1984-10-23 Ciba-Geigy Corporation N-Substituted-2-pyridylindoles
US4511573A (en) * 1983-05-17 1985-04-16 Ciba-Geigy Corporation 3-Substituted-2-(heteroaryl) indoles
US5137910A (en) * 1989-05-05 1992-08-11 C.D. Searle & Co. Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders
US5229413A (en) * 1989-05-05 1993-07-20 G. D. Searle & Co. Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders
CA2118697A1 (en) * 1991-09-11 1993-03-18 Satoshi Okada Indole derivatives as 5-alpha-reductase inhibitor
GB9204024D0 (en) * 1992-02-25 1992-04-08 Fujisawa Pharmaceutical Co Indole derivatives
GB9204365D0 (en) * 1992-02-28 1992-04-08 Pfizer Ltd Indoles
ES2099007B1 (es) * 1993-07-16 1997-12-01 Pfizer Res & Dev Derivados de indol.
GB9716657D0 (en) * 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
GB9803226D0 (en) * 1998-02-17 1998-04-08 Zeneca Ltd Chemical compounds
IL138711A0 (en) * 1998-03-31 2001-10-31 Inst Pharmaceutical Discovery Substituted indolealkanoic acids
TNSN99224A1 (fr) 1998-12-01 2005-11-10 Inst For Pharm Discovery Inc Methodes de reduction des niveaux de glucose et triglyceride en serum et pour suppression de l'antigenese utilisant les acides la indolealkanoique
GB9902459D0 (en) * 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902453D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902452D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902455D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
GB9902461D0 (en) 1999-02-05 1999-03-24 Zeneca Ltd Chemical compounds
SK288365B6 (sk) 1999-02-10 2016-07-01 Astrazeneca Ab Medziprodukty pre chinazolínové deriváty ako inhibítory angiogenézy
GB0000625D0 (en) 2000-01-13 2000-03-01 Zeneca Ltd Chemical compounds
ES2290318T3 (es) * 2001-06-20 2008-02-16 Wyeth Derivados sustituidos de acido indolico como inhibidores del inhibidor del activador del plasminogeno-1 (pai-1).
TWI224101B (en) * 2001-06-20 2004-11-21 Wyeth Corp Substituted naphthyl indole derivatives as inhibitors of plasminogen activator inhibitor type-1 (PAI-1)
US7632955B2 (en) * 2001-12-13 2009-12-15 National Health Research Institutes Indole compounds
US6933316B2 (en) * 2001-12-13 2005-08-23 National Health Research Institutes Indole compounds
US7528165B2 (en) * 2001-12-13 2009-05-05 National Health Research Institutes Indole compounds
JP2005532363A (ja) * 2002-06-14 2005-10-27 メルク　エンド　カムパニー　インコーポレーテッド 高眼圧を治療するための眼用組成物
CA2493755A1 (en) * 2002-07-26 2004-02-05 The Institutes For Pharmaceutical Discovery, Llc Substituted indolealkanoic acids derivative and formulations containing same for use in treatment of diabetic complications
JP2006514640A (ja) * 2002-12-10 2006-05-11 ワイス プラスミノゲンアクティベータインヒビターのインヒビターとしての置換３−アルキル及び３−アリールアルキル１ｈ−イル酢酸誘導体
AU2003296324A1 (en) * 2002-12-10 2004-06-30 Wyeth Aryl, aryloxy, and alkyloxy substituted 1h-indol-3-yl glyoxylic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
MXPA05006287A (es) * 2002-12-10 2005-09-08 Wyeth Corp Derivados de acido indoloxo-acetilaminoacetico sustituidos como inhibidores del inhibidor del activador de plasminogeno 1 (pai-1).
UA80453C2 (en) * 2002-12-10 2007-09-25 Derivatives of substituted dyhydropyranoindol-3,4-dion as inhibitors of plasminogen activator inhibitor-1 (pai-1)
WO2004052855A2 (en) * 2002-12-10 2004-06-24 Wyeth Substituted 3-carbonyl-1h-indol-1-yl acetic acid derivatives as inhibitors of plasminogen activator inhibitor-1 (pai-1)
ATE504568T1 (de) * 2003-08-07 2011-04-15 Nat Health Research Institutes Indol-verbindungen als inhibitoren der tubulin- polymerisation zur behandlung von angiogenesisbezogenen erkrankungen
US7141592B2 (en) * 2003-09-25 2006-11-28 Wyeth Substituted oxadiazolidinediones
US7420083B2 (en) * 2003-09-25 2008-09-02 Wyeth Substituted aryloximes
US7442805B2 (en) * 2003-09-25 2008-10-28 Wyeth Substituted sulfonamide-indoles
US7411083B2 (en) * 2003-09-25 2008-08-12 Wyeth Substituted acetic acid derivatives
US7163954B2 (en) * 2003-09-25 2007-01-16 Wyeth Substituted naphthyl benzothiophene acids
US7534894B2 (en) 2003-09-25 2009-05-19 Wyeth Biphenyloxy-acids
US7351726B2 (en) * 2003-09-25 2008-04-01 Wyeth Substituted oxadiazolidinediones
US7342039B2 (en) * 2003-09-25 2008-03-11 Wyeth Substituted indole oximes
US7332521B2 (en) * 2003-09-25 2008-02-19 Wyeth Substituted indoles
US7582773B2 (en) * 2003-09-25 2009-09-01 Wyeth Substituted phenyl indoles
US7446201B2 (en) * 2003-09-25 2008-11-04 Wyeth Substituted heteroaryl benzofuran acids
US7265148B2 (en) * 2003-09-25 2007-09-04 Wyeth Substituted pyrrole-indoles
US7268159B2 (en) * 2003-09-25 2007-09-11 Wyeth Substituted indoles
GB0324763D0 (en) * 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
US7186749B2 (en) * 2004-08-23 2007-03-06 Wyeth Pyrrolo-naphthyl acids and methods for using them
BRPI0514572A (pt) 2004-08-23 2008-06-17 Wyeth Corp ácidos de tiazolo-naftila
KR20070055563A (ko) * 2004-08-23 2007-05-30 와이어쓰 혈전증 및 심혈관 질병의 치료에 유용한 플라스미노겐활성화제 억제제 타입-1(ｐａｉ-1)의 조절제로서의옥사졸로-나프틸 산
JP2008521829A (ja) * 2004-11-30 2008-06-26 プレキシコン，インコーポレーテッド Ｐｐａｒ活性化合物
JP2008521831A (ja) * 2004-11-30 2008-06-26 プレキシコン，インコーポレーテッド Ｐｐａｒ活性化合物
US7560481B2 (en) * 2004-12-21 2009-07-14 Abbott Laboratories Indoles are cannabinoid receptor ligands
US7456289B2 (en) * 2004-12-31 2008-11-25 National Health Research Institutes Anti-tumor compounds
US7683091B2 (en) * 2005-08-17 2010-03-23 Wyeth Substituted indoles and methods of their use
NZ567162A (en) * 2005-09-07 2011-06-30 Plexxikon Inc 1, 3-disubstituted indole derivatives for use as PPAR modulators
US8841334B2 (en) * 2006-05-31 2014-09-23 Abbvie Inc. Compounds as cannabinoid receptor ligands and uses thereof
MX2008015214A (es) * 2006-05-31 2008-12-12 Abbott Lab Compuestos como ligandos de receptor canabinoide y sus usos.
MX2009000801A (es) 2006-07-22 2009-02-03 Oxagen Ltd Compuestos que tienen actividad antagonista crth2.
PE20090159A1 (es) * 2007-03-08 2009-02-21 Plexxikon Inc COMPUESTOS DERIVADOS DE ACIDO INDOL-PROPIONICO COMO MODULADORES PPARs
CN101765594A (zh) 2007-03-28 2010-06-30 雅培制药有限公司 作为大麻素受体配体的1,3-噻唑-2(3h)-亚基化合物
US7872033B2 (en) * 2007-04-17 2011-01-18 Abbott Laboratories Compounds as cannabinoid receptor ligands
MX2009012374A (es) * 2007-05-18 2009-12-01 Abbott Lab Compuestos novedosos como ligandos del receptor de canabinoides.
US9193713B2 (en) * 2007-10-12 2015-11-24 Abbvie Inc. Compounds as cannabinoid receptor ligands
US7750027B2 (en) * 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
DK2250161T3 (da) 2008-01-18 2014-01-27 Atopix Therapeutics Ltd Forbindelser med CRTH2-antagonistaktivitet
JP2011509990A (ja) * 2008-01-22 2011-03-31 オキサジェン リミテッド Ｃｒｔｈ２アンタゴニスト活性を有する化合物
US8846730B2 (en) * 2008-09-08 2014-09-30 Abbvie Inc. Compounds as cannabinoid receptor ligands
US8859596B2 (en) * 2008-09-16 2014-10-14 Abbvie Inc. Compounds as cannabinoid receptor ligands
PA8854001A1 (es) * 2008-12-16 2010-07-27 Abbott Lab Compuestos novedosos como ligandos de receptores de canabinoides
CN103086943B (zh) * 2011-11-04 2015-04-15 山东亨利医药科技有限责任公司 作为crth2受体拮抗剂的吲哚类衍生物
US8715529B1 (en) 2012-01-23 2014-05-06 Arrowhead Center, Inc. Synthesis and applications of triazaborolopyridinium compounds and substituted triazaborolopyridinium compounds and methods of use
GB201322273D0 (en) 2013-12-17 2014-01-29 Atopix Therapeutics Ltd Process
GB201407807D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
GB201407820D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1492929A (fr) * 1966-05-11 1967-08-25 Roussel Uclaf Nouveaux 1-(omega-carboxyalcoyl) indoles substitués et procédé de préparation

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8168673B2 (en) 2008-01-22 2012-05-01 Oxagen Limited Compounds having CRTH2 antagonist activity
GB2457040A (en) * 2008-01-30 2009-08-05 Oxagen Ltd 1-Acetic acid indole derivatives with PGD2 activity

Also Published As

Publication number Publication date
CH507238A (fr) 1971-05-15
US3557142A (en) 1971-01-19
FR2002284B1 (enExample) 1973-07-13
DE1908541A1 (de) 1969-09-18
NL6902641A (enExample) 1969-08-22
US3843683A (en) 1974-10-22
JPS4843740B1 (enExample) 1973-12-20
BR6906477D0 (pt) 1973-01-16
FR2002284A1 (enExample) 1969-10-17
BE728675A (enExample) 1969-08-20
SE350259B (enExample) 1972-10-23

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees