GB1197973A - Penicillins - Google Patents
PenicillinsInfo
- Publication number
- GB1197973A GB1197973A GB1770267A GB1770267A GB1197973A GB 1197973 A GB1197973 A GB 1197973A GB 1770267 A GB1770267 A GB 1770267A GB 1770267 A GB1770267 A GB 1770267A GB 1197973 A GB1197973 A GB 1197973A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- phenyl
- salts
- penicillins
- aralkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Abstract
1,197,973. Penicillins. BEECHAM GROUP Ltd. 18 April, 1968 [18 April, 1967], No. 17702/67. Addition to 1,004,670. Heading C2A. Penicillins of general Formula I and non-toxic salts thereof, wherein R is a phenyl, substituted phenyl, furyl or thienyl group, are prepared by chemically hydrolysing an intermediate penicillin of general Formula II or a non-toxic salt thereof, to remove group R<SP>2</SP>, where R<SP>2</SP> is a phenyl, substituted phenyl, naphthyl or substituted naphthyl group or the group -CHR<SP>11</SP>CXYZ wherein R<SP>11</SP> is H or an alkyl, phenyl, halogenomethyl or alkylsulphonyl group, X is halogen, NO 2 , alkoxy, aryloxy, aralkoxy, alkylsulphonyl, arylsulphonyl or aralkylsulphonyl and Y and Z are the same or different and each may be H, halogen, CH 3 , C 2 H 5 or when X is alkoxy or aralkoxy, Y and Z may together represent oxygen. Hydrolysis is by means of an aqueous or partly aqueous solution of pH 7 to 11À5 at 0-50‹ C., e.g. aqueous solution of NaHCO 3 , Na 2 HPO 4 or sodium borate. Alternatively, an organic base such as a water-miscible tertiary amine or quaternary ammonium hydroxide may be used. The preferred intermediates are those where R<SP>2</SP> is phenyl or 2,2,2-trichloroethyl. The salts may be inorganic e.g. sodium, potassium, calcium, aluminium or ammonium, or organic e.g. amine for example procaine salts. Specifications 1,004,670, 1,160,211 and 1,133,886 are referred to.
Priority Applications (12)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1770267A GB1197973A (en) | 1967-04-18 | 1967-04-18 | Penicillins |
IE42268A IE32038B1 (en) | 1967-04-18 | 1968-04-10 | Penicillins |
FR1560842D FR1560842A (en) | 1967-04-18 | 1968-04-16 | |
ES352849A ES352849A1 (en) | 1967-04-18 | 1968-04-17 | Penicillins |
DK170368A DK132796C (en) | 1967-04-18 | 1968-04-17 | PENICILLINE PROCEDURES |
AT372468A AT283591B (en) | 1967-04-18 | 1968-04-17 | Process for the production of penicillins |
CH570868A CH525237A (en) | 1967-04-18 | 1968-04-18 | Penicillin derivs antibacterial |
JP2611868A JPS5118434B1 (en) | 1967-04-18 | 1968-04-18 | |
NL6805524A NL6805524A (en) | 1967-04-18 | 1968-04-18 | |
BE713868D BE713868A (en) | 1967-04-18 | 1968-04-18 | |
FI107268A FI51813C (en) | 1967-04-18 | 1968-04-18 | A process for the preparation of alpha-carboxypenicillin and its pharmaceutically acceptable salts. |
DE19681770225 DE1770225C3 (en) | 1967-04-18 | 1968-04-18 | Process for the production of penicillins |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1770267A GB1197973A (en) | 1967-04-18 | 1967-04-18 | Penicillins |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1197973A true GB1197973A (en) | 1970-07-08 |
Family
ID=10099714
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1770267A Expired GB1197973A (en) | 1967-04-18 | 1967-04-18 | Penicillins |
Country Status (11)
Country | Link |
---|---|
JP (1) | JPS5118434B1 (en) |
AT (1) | AT283591B (en) |
BE (1) | BE713868A (en) |
CH (1) | CH525237A (en) |
DK (1) | DK132796C (en) |
ES (1) | ES352849A1 (en) |
FI (1) | FI51813C (en) |
FR (1) | FR1560842A (en) |
GB (1) | GB1197973A (en) |
IE (1) | IE32038B1 (en) |
NL (1) | NL6805524A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2129429A (en) * | 1982-10-15 | 1984-05-16 | Beecham Group Plc | B-lactam antibiotics |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2635477A1 (en) * | 1975-08-20 | 1977-03-03 | Beecham Group Ltd | PROCESS FOR THE PRODUCTION OF SOLID, PRACTICALLY PURE SODIUM AND POTASSIUM SALT OF CLAVULANIC ACID |
-
1967
- 1967-04-18 GB GB1770267A patent/GB1197973A/en not_active Expired
-
1968
- 1968-04-10 IE IE42268A patent/IE32038B1/en unknown
- 1968-04-16 FR FR1560842D patent/FR1560842A/fr not_active Expired
- 1968-04-17 DK DK170368A patent/DK132796C/en active
- 1968-04-17 AT AT372468A patent/AT283591B/en not_active IP Right Cessation
- 1968-04-17 ES ES352849A patent/ES352849A1/en not_active Expired
- 1968-04-18 JP JP2611868A patent/JPS5118434B1/ja active Pending
- 1968-04-18 FI FI107268A patent/FI51813C/en active
- 1968-04-18 CH CH570868A patent/CH525237A/en not_active IP Right Cessation
- 1968-04-18 NL NL6805524A patent/NL6805524A/xx unknown
- 1968-04-18 BE BE713868D patent/BE713868A/xx unknown
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2129429A (en) * | 1982-10-15 | 1984-05-16 | Beecham Group Plc | B-lactam antibiotics |
US4598074A (en) * | 1982-10-15 | 1986-07-01 | Beecham Group P.L.C. | β-lactam antibiotics |
Also Published As
Publication number | Publication date |
---|---|
DK132796B (en) | 1976-02-09 |
CH525237A (en) | 1972-07-15 |
FR1560842A (en) | 1969-03-21 |
FI51813C (en) | 1977-04-12 |
BE713868A (en) | 1968-10-18 |
JPS5118434B1 (en) | 1976-06-09 |
IE32038L (en) | 1968-10-18 |
IE32038B1 (en) | 1973-03-21 |
DE1770225A1 (en) | 1971-10-07 |
NL6805524A (en) | 1968-10-21 |
AT283591B (en) | 1970-08-10 |
FI51813B (en) | 1976-12-31 |
ES352849A1 (en) | 1969-08-01 |
DK132796C (en) | 1976-07-12 |
DE1770225B2 (en) | 1976-03-25 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed |