IE32038L - Penicillins - Google Patents
PenicillinsInfo
- Publication number
- IE32038L IE32038L IE42268A IE42268A IE32038L IE 32038 L IE32038 L IE 32038L IE 42268 A IE42268 A IE 42268A IE 42268 A IE42268 A IE 42268A IE 32038 L IE32038 L IE 32038L
- Authority
- IE
- Ireland
- Prior art keywords
- group
- phenyl
- salts
- penicillins
- aralkoxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
Abstract
1,197,973. Penicillins. BEECHAM GROUP Ltd. 18 April, 1968 [18 April, 1967], No. 17702/67. Addition to 1,004,670. Heading C2A. Penicillins of general Formula I and non-toxic salts thereof, wherein R is a phenyl, substituted phenyl, furyl or thienyl group, are prepared by chemically hydrolysing an intermediate penicillin of general Formula II or a non-toxic salt thereof, to remove group R<SP>2</SP>, where R<SP>2</SP> is a phenyl, substituted phenyl, naphthyl or substituted naphthyl group or the group -CHR<SP>11</SP>CXYZ wherein R<SP>11</SP> is H or an alkyl, phenyl, halogenomethyl or alkylsulphonyl group, X is halogen, NO 2 , alkoxy, aryloxy, aralkoxy, alkylsulphonyl, arylsulphonyl or aralkylsulphonyl and Y and Z are the same or different and each may be H, halogen, CH 3 , C 2 H 5 or when X is alkoxy or aralkoxy, Y and Z may together represent oxygen. Hydrolysis is by means of an aqueous or partly aqueous solution of pH 7 to 11À5 at 0-50‹ C., e.g. aqueous solution of NaHCO 3 , Na 2 HPO 4 or sodium borate. Alternatively, an organic base such as a water-miscible tertiary amine or quaternary ammonium hydroxide may be used. The preferred intermediates are those where R<SP>2</SP> is phenyl or 2,2,2-trichloroethyl. The salts may be inorganic e.g. sodium, potassium, calcium, aluminium or ammonium, or organic e.g. amine for example procaine salts. Specifications 1,004,670, 1,160,211 and 1,133,886 are referred to.
[GB1197973A]
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1770267A GB1197973A (en) | 1967-04-18 | 1967-04-18 | Penicillins |
Publications (2)
Publication Number | Publication Date |
---|---|
IE32038L true IE32038L (en) | 1968-10-18 |
IE32038B1 IE32038B1 (en) | 1973-03-21 |
Family
ID=10099714
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
IE42268A IE32038B1 (en) | 1967-04-18 | 1968-04-10 | Penicillins |
Country Status (11)
Country | Link |
---|---|
JP (1) | JPS5118434B1 (en) |
AT (1) | AT283591B (en) |
BE (1) | BE713868A (en) |
CH (1) | CH525237A (en) |
DK (1) | DK132796C (en) |
ES (1) | ES352849A1 (en) |
FI (1) | FI51813C (en) |
FR (1) | FR1560842A (en) |
GB (1) | GB1197973A (en) |
IE (1) | IE32038B1 (en) |
NL (1) | NL6805524A (en) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2635477A1 (en) * | 1975-08-20 | 1977-03-03 | Beecham Group Ltd | PROCESS FOR THE PRODUCTION OF SOLID, PRACTICALLY PURE SODIUM AND POTASSIUM SALT OF CLAVULANIC ACID |
US4598074A (en) * | 1982-10-15 | 1986-07-01 | Beecham Group P.L.C. | β-lactam antibiotics |
-
1967
- 1967-04-18 GB GB1770267A patent/GB1197973A/en not_active Expired
-
1968
- 1968-04-10 IE IE42268A patent/IE32038B1/en unknown
- 1968-04-16 FR FR1560842D patent/FR1560842A/fr not_active Expired
- 1968-04-17 ES ES352849A patent/ES352849A1/en not_active Expired
- 1968-04-17 AT AT372468A patent/AT283591B/en not_active IP Right Cessation
- 1968-04-17 DK DK170368A patent/DK132796C/en active
- 1968-04-18 NL NL6805524A patent/NL6805524A/xx unknown
- 1968-04-18 CH CH570868A patent/CH525237A/en not_active IP Right Cessation
- 1968-04-18 BE BE713868D patent/BE713868A/xx unknown
- 1968-04-18 FI FI107268A patent/FI51813C/en active
- 1968-04-18 JP JP2611868A patent/JPS5118434B1/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
NL6805524A (en) | 1968-10-21 |
DE1770225A1 (en) | 1971-10-07 |
FI51813B (en) | 1976-12-31 |
BE713868A (en) | 1968-10-18 |
FR1560842A (en) | 1969-03-21 |
DK132796B (en) | 1976-02-09 |
DK132796C (en) | 1976-07-12 |
FI51813C (en) | 1977-04-12 |
IE32038B1 (en) | 1973-03-21 |
CH525237A (en) | 1972-07-15 |
JPS5118434B1 (en) | 1976-06-09 |
GB1197973A (en) | 1970-07-08 |
ES352849A1 (en) | 1969-08-01 |
DE1770225B2 (en) | 1976-03-25 |
AT283591B (en) | 1970-08-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SE8305916D0 (en) | INTERMEDIATES FOR PENICILLANIC ACID-1,1-Dioxide PREPARATION | |
SE7807810L (en) | 3-METHYLENIC LAMIC ACID DERIVATIVE | |
IE32038L (en) | Penicillins | |
GB1289358A (en) | ||
IE801068L (en) | Substituted acetophenones. | |
GB1426869A (en) | Penicillins | |
GB1144219A (en) | Activated esters of 7-aminocephalosporanic acid | |
GB1250611A (en) | ||
IE33511L (en) | Penicillins | |
AU553027B2 (en) | 6alpha-methoxy penicillins | |
GB1234426A (en) | ||
GB1134682A (en) | Improvements in or relating to derivatives of 6-aminopenicillanic acid | |
GB1449749A (en) | Preparation of penicillins | |
AU529233B2 (en) | Cephalosporin esters and ethers | |
GB1130370A (en) | Esters of 6-aminopenicillanic acid | |
IE34347B1 (en) | Penicillins | |
GB1138745A (en) | Penicillins | |
GB1053818A (en) | ||
GB1051675A (en) | ||
GB1315443A (en) | Penicillins | |
GB1297069A (en) | ||
GB1134808A (en) | Penicillins | |
SE7503565L (en) | WAY TO PRODUCE PROPANOLAMINE DERIVATIVES | |
IE39409B1 (en) | X-ray contras agents | |
GB1165333A (en) | Penicillins |