GB1449749A - Preparation of penicillins - Google Patents
Preparation of penicillinsInfo
- Publication number
- GB1449749A GB1449749A GB2735874A GB2735874A GB1449749A GB 1449749 A GB1449749 A GB 1449749A GB 2735874 A GB2735874 A GB 2735874A GB 2735874 A GB2735874 A GB 2735874A GB 1449749 A GB1449749 A GB 1449749A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- penicillins
- salt
- hydrogen
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1449749 α-Carboxypenicillins BEECHAM GROUP Ltd 12 May 1975 [20 June 1974] 27358/74 Heading C2C Penicillins of the Formula (II) wherein R is a phenyl, thienyl or furyl group which may contain a C 1-6 alkyl or halo-substituent; R<SP>1</SP> is hydrogen, a salt-forming cation or a C 1-12 hydrocarbon group and R<SP>11</SP> is hydrogen or a salt-forming cation, are obtained by reacting a substituted malonic acid halide of Formula (III) wherein X is Cl or Br, with 6-aminopenicillanic acid in an aqueous acid medium at a pH of from 0À5 to 2À5 and at a temperature of from - 50‹ to +20‹ C., and thereafter if necessary and if desired converting one group R<SP>1</SP> and/or R<SP>11</SP> to another group R<SP>1</SP> and/or R<SP>11</SP> by conventional methods.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2735874A GB1449749A (en) | 1974-06-20 | 1974-06-20 | Preparation of penicillins |
CA228,356A CA1032160A (en) | 1974-06-20 | 1975-06-03 | Preparation of penicillins |
FR7517398A FR2275478A1 (en) | 1974-06-20 | 1975-06-04 | PROCESS FOR PREPARING PENICILLINS |
BE157102A BE829958A (en) | 1974-06-20 | 1975-06-06 | PROCESS FOR PREPARING PENICILLINS |
JP7542275A JPS51128996A (en) | 1974-06-20 | 1975-06-20 | Production of penicillin |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2735874A GB1449749A (en) | 1974-06-20 | 1974-06-20 | Preparation of penicillins |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1449749A true GB1449749A (en) | 1976-09-15 |
Family
ID=10258315
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2735874A Expired GB1449749A (en) | 1974-06-20 | 1974-06-20 | Preparation of penicillins |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPS51128996A (en) |
BE (1) | BE829958A (en) |
CA (1) | CA1032160A (en) |
FR (1) | FR2275478A1 (en) |
GB (1) | GB1449749A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101735244B (en) * | 2008-11-05 | 2012-01-18 | 鲁南制药集团股份有限公司 | Method for preparing broad-spectrum penicillin antibiotic ticarcillin sodium |
-
1974
- 1974-06-20 GB GB2735874A patent/GB1449749A/en not_active Expired
-
1975
- 1975-06-03 CA CA228,356A patent/CA1032160A/en not_active Expired
- 1975-06-04 FR FR7517398A patent/FR2275478A1/en not_active Withdrawn
- 1975-06-06 BE BE157102A patent/BE829958A/en unknown
- 1975-06-20 JP JP7542275A patent/JPS51128996A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101735244B (en) * | 2008-11-05 | 2012-01-18 | 鲁南制药集团股份有限公司 | Method for preparing broad-spectrum penicillin antibiotic ticarcillin sodium |
Also Published As
Publication number | Publication date |
---|---|
BE829958A (en) | 1975-12-08 |
JPS51128996A (en) | 1976-11-10 |
FR2275478A1 (en) | 1976-01-16 |
CA1032160A (en) | 1978-05-30 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |