GB1449749A - Preparation of penicillins - Google Patents

Preparation of penicillins

Info

Publication number
GB1449749A
GB1449749A GB2735874A GB2735874A GB1449749A GB 1449749 A GB1449749 A GB 1449749A GB 2735874 A GB2735874 A GB 2735874A GB 2735874 A GB2735874 A GB 2735874A GB 1449749 A GB1449749 A GB 1449749A
Authority
GB
United Kingdom
Prior art keywords
group
penicillins
salt
hydrogen
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2735874A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Priority to GB2735874A priority Critical patent/GB1449749A/en
Priority to CA228,356A priority patent/CA1032160A/en
Priority to FR7517398A priority patent/FR2275478A1/en
Priority to BE157102A priority patent/BE829958A/en
Priority to JP7542275A priority patent/JPS51128996A/en
Publication of GB1449749A publication Critical patent/GB1449749A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1449749 α-Carboxypenicillins BEECHAM GROUP Ltd 12 May 1975 [20 June 1974] 27358/74 Heading C2C Penicillins of the Formula (II) wherein R is a phenyl, thienyl or furyl group which may contain a C 1-6 alkyl or halo-substituent; R<SP>1</SP> is hydrogen, a salt-forming cation or a C 1-12 hydrocarbon group and R<SP>11</SP> is hydrogen or a salt-forming cation, are obtained by reacting a substituted malonic acid halide of Formula (III) wherein X is Cl or Br, with 6-aminopenicillanic acid in an aqueous acid medium at a pH of from 0À5 to 2À5 and at a temperature of from - 50‹ to +20‹ C., and thereafter if necessary and if desired converting one group R<SP>1</SP> and/or R<SP>11</SP> to another group R<SP>1</SP> and/or R<SP>11</SP> by conventional methods.
GB2735874A 1974-06-20 1974-06-20 Preparation of penicillins Expired GB1449749A (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
GB2735874A GB1449749A (en) 1974-06-20 1974-06-20 Preparation of penicillins
CA228,356A CA1032160A (en) 1974-06-20 1975-06-03 Preparation of penicillins
FR7517398A FR2275478A1 (en) 1974-06-20 1975-06-04 PROCESS FOR PREPARING PENICILLINS
BE157102A BE829958A (en) 1974-06-20 1975-06-06 PROCESS FOR PREPARING PENICILLINS
JP7542275A JPS51128996A (en) 1974-06-20 1975-06-20 Production of penicillin

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2735874A GB1449749A (en) 1974-06-20 1974-06-20 Preparation of penicillins

Publications (1)

Publication Number Publication Date
GB1449749A true GB1449749A (en) 1976-09-15

Family

ID=10258315

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2735874A Expired GB1449749A (en) 1974-06-20 1974-06-20 Preparation of penicillins

Country Status (5)

Country Link
JP (1) JPS51128996A (en)
BE (1) BE829958A (en)
CA (1) CA1032160A (en)
FR (1) FR2275478A1 (en)
GB (1) GB1449749A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101735244B (en) * 2008-11-05 2012-01-18 鲁南制药集团股份有限公司 Method for preparing broad-spectrum penicillin antibiotic ticarcillin sodium

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101735244B (en) * 2008-11-05 2012-01-18 鲁南制药集团股份有限公司 Method for preparing broad-spectrum penicillin antibiotic ticarcillin sodium

Also Published As

Publication number Publication date
BE829958A (en) 1975-12-08
JPS51128996A (en) 1976-11-10
FR2275478A1 (en) 1976-01-16
CA1032160A (en) 1978-05-30

Similar Documents

Publication Publication Date Title
GB1409843A (en) Prostaglandin intermediates
ES421614A1 (en) Electrolytic process for producing n-phosphonomethyl glycine
GB1418822A (en) Imidazo-and pyrimido-2,1-b-quinazolin-2-ones and a process for the preparation thereof
IE44105L (en) Imidazolyl-alkyl sulphides
ES371709A1 (en) Synthetic penicillins
GB1449749A (en) Preparation of penicillins
GB1528440A (en) Process for the preparation of cyclic ketones
GB1125557A (en) Penicillins
GB1498535A (en) Heterocyclic compounds
GB1526210A (en) Ethylenediamineplatinum(ii)-2,4-dioxopyrimidine complexes
ES8306505A1 (en) Process for producing an antibiotic.
GB1310382A (en) Process for the preparation of glucofuranosides
IE33511L (en) Penicillins
ES401264A1 (en) Penicillins
ES381429A1 (en) Penicillins
GB1130370A (en) Esters of 6-aminopenicillanic acid
GB1197973A (en) Penicillins
GB1363068A (en) Amino-ketone derivatives and their method of preparation
IE39409B1 (en) X-ray contras agents
GB1508314A (en) 7-alpha-methoxy-7-beta-(substituted-acetamido)-cephalosporins and methods for their preparation
GB1292662A (en) Bicycloheptaneheptanoic acids and esters thereof
KR830002773A (en) Method for producing 3-thienyl malonic acid
GB1256835A (en)
GB1356716A (en) 17-hydroxy-17alpha-mercapto-3-oxo-17alpha-pregn-4-ene-21-carboxylic acid y-lactone
GB1297555A (en)

Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee