GB1192937A - Process for Producing Collagenase - Google Patents

Process for Producing Collagenase

Info

Publication number
GB1192937A
GB1192937A GB29324/67A GB2932467A GB1192937A GB 1192937 A GB1192937 A GB 1192937A GB 29324/67 A GB29324/67 A GB 29324/67A GB 2932467 A GB2932467 A GB 2932467A GB 1192937 A GB1192937 A GB 1192937A
Authority
GB
United Kingdom
Prior art keywords
enzyme
petrolatum
division
producing collagenase
collagenase
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB29324/67A
Inventor
Angelo Joseph Chiulli
Edwin Henry Wegman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Agricultural Biologicals Corp
Original Assignee
Agricultural Biologicals Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agricultural Biologicals Corp filed Critical Agricultural Biologicals Corp
Publication of GB1192937A publication Critical patent/GB1192937A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/842—Clostridium

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

1,192,937. Medicines comprising enzymes. AGRICULTURAL BIOLOGICALS CORP. 26 June, 1967 [8 July, 1966], No. 29324/67. Heading A5B. [Also in Division C3] An enzyme composition having proteolytic and collagenase activity (see Division C3) has medical applications for debridement of necrotic and moribund tissue. Examples are given of ointments containing 99.5% petrolatum and 0.5% of enzyme, and 98.5% petrolatum, 1 % of a stneptomycin/penicillin mixture and 0.5% of enzyme. The enzyme may also be injected as a 0.2 to 5% solution in physiological saline.
GB29324/67A 1966-07-08 1967-06-26 Process for Producing Collagenase Expired GB1192937A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56370266A 1966-07-08 1966-07-08

Publications (1)

Publication Number Publication Date
GB1192937A true GB1192937A (en) 1970-05-28

Family

ID=24251557

Family Applications (1)

Application Number Title Priority Date Filing Date
GB29324/67A Expired GB1192937A (en) 1966-07-08 1967-06-26 Process for Producing Collagenase

Country Status (5)

Country Link
US (1) US3705083A (en)
JP (1) JPS4924669B1 (en)
BR (1) BR6791131D0 (en)
DE (1) DE1642578C3 (en)
GB (1) GB1192937A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2216992A1 (en) * 1973-02-12 1974-09-06 Anvar Low MW, purified collagenase prepn - by ion-exchange chromatography of enzyme from first-stage larvae of hypoderma spp.

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4524065A (en) * 1983-08-04 1985-06-18 Bio-Specifics N.V. Method for the prevention and treatment of scars with enzymes
JPS60188066A (en) * 1984-03-09 1985-09-25 Akira Endo Novel collagenase discolysin and its preparation
US5177017A (en) * 1990-03-22 1993-01-05 Trigen, Inc. Molecular cloning of the genes responsible for collagenase production from Clostridium histolyticum
CA2047306A1 (en) * 1990-07-23 1992-01-24 Milan Holjevac Mutant bacterium clostridium histolyticum, a process for the obtaining thereof, and its use in the production of clostripain-free collagenase
US5173295A (en) * 1990-10-05 1992-12-22 Advance Biofactures Of Curacao, N.V. Method of enhancing the regeneration of injured nerves and adhesive pharamaceutical formulation therefor
US5393792A (en) * 1991-11-20 1995-02-28 Advance Biofactures Of Curacao, N.V. High dosage topical forms of collagenase
US5332503A (en) * 1993-04-16 1994-07-26 Baxter International Inc. Process for purifying collagenase
JP3028852B2 (en) * 1994-06-24 2000-04-04 ロシュ ダイアグノスティックス コーポレーション Purified mixture of collagenase and two other proteases obtained from Histolyticus
US5851522A (en) * 1995-06-07 1998-12-22 Trustees Of Tufts College Enhancing keratinocyte migration
US5989888A (en) * 1996-01-24 1999-11-23 Roche Diagnostics Corporation Purified mixture of collagenase I, collagenase II and two other proteases
US5830741A (en) * 1996-12-06 1998-11-03 Boehringer Mannheim Corporation Composition for tissue dissociation containing collagenase I and II from clostridium histolyticum and a neutral protease
US8323642B2 (en) * 2006-12-13 2012-12-04 Depuy Mitek, Inc. Tissue fusion method using collagenase for repair of soft tissue
US10071143B1 (en) 2007-05-03 2018-09-11 The Research Foundation For The State University Of New York Methods for non-surgical treatment of carpal tunnel syndrome
US20100159564A1 (en) * 2007-11-30 2010-06-24 Dwulet Francis E Protease resistant recombinant bacterial collagenases
US9694100B2 (en) 2009-12-08 2017-07-04 Smith & Nephew, Inc. Enzymatic wound debriding compositions with enhanced enzymatic activity
WO2014066622A2 (en) 2012-10-24 2014-05-01 The Research Foundation For The State University Of New York Use of collagenase to treat glaucoma
US11938173B2 (en) 2014-12-12 2024-03-26 Smith & Nephew, Inc. Use of Clostridium histolyticum protease mixture in promoting wound healing
KR102618948B1 (en) 2016-11-17 2023-12-27 이오반스 바이오테라퓨틱스, 인크. Residual tumor infiltrating lymphocytes and methods of making and using the same
WO2019118631A1 (en) * 2017-12-12 2019-06-20 Bio Med Sciences, Inc. Debriding wound dressing, process of manufacture and useful articles thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2216992A1 (en) * 1973-02-12 1974-09-06 Anvar Low MW, purified collagenase prepn - by ion-exchange chromatography of enzyme from first-stage larvae of hypoderma spp.

Also Published As

Publication number Publication date
US3705083A (en) 1972-12-05
DE1642578C3 (en) 1974-09-19
DE1642578A1 (en) 1972-03-09
DE1642578B2 (en) 1974-02-14
JPS4924669B1 (en) 1974-06-25
BR6791131D0 (en) 1973-05-10

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PE20 Patent expired after termination of 20 years