GB1191237A - 0,3-Diazacyclo alkeno[2,1-a]isoindole Derivatives and a process for the mnufacture thereof - Google Patents
0,3-Diazacyclo alkeno[2,1-a]isoindole Derivatives and a process for the mnufacture thereofInfo
- Publication number
- GB1191237A GB1191237A GB04967/68A GB1496768A GB1191237A GB 1191237 A GB1191237 A GB 1191237A GB 04967/68 A GB04967/68 A GB 04967/68A GB 1496768 A GB1496768 A GB 1496768A GB 1191237 A GB1191237 A GB 1191237A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- compounds
- prepared
- compound
- broken lines
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000000904 isoindolyl group Chemical class C=1(NC=C2C=CC=CC12)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 13
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 125000003545 alkoxy group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 239000007858 starting material Substances 0.000 abstract 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 abstract 2
- CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 abstract 2
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 2
- 229940121375 antifungal agent Drugs 0.000 abstract 2
- 239000003429 antifungal agent Substances 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000010992 reflux Methods 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- 239000008096 xylene Substances 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 abstract 1
- HIHTVTATSKDEQF-UHFFFAOYSA-N 2-benzoylbenzaldehyde Chemical compound O=CC1=CC=CC=C1C(=O)C1=CC=CC=C1 HIHTVTATSKDEQF-UHFFFAOYSA-N 0.000 abstract 1
- HALLUMUPPVGEIO-UHFFFAOYSA-N 2-phenyl-3,5-dihydro-2H-imidazo[2,1-a]isoindole Chemical compound C1(=CC=CC=C1)C1N=C2N(CC3=CC=CC=C23)C1 HALLUMUPPVGEIO-UHFFFAOYSA-N 0.000 abstract 1
- OUDUVJXYNXZDIM-UHFFFAOYSA-N 5-phenyl-3,5-dihydro-2h-imidazo[2,1-a]isoindole Chemical compound C12=CC=CC=C2C2=NCCN2C1C1=CC=CC=C1 OUDUVJXYNXZDIM-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 229940124332 anorexigenic agent Drugs 0.000 abstract 1
- 230000002891 anorexigenic effect Effects 0.000 abstract 1
- 230000003501 anti-edematous effect Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 229940125716 antipyretic agent Drugs 0.000 abstract 1
- 239000002830 appetite depressant Substances 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 230000005587 bubbling Effects 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 150000004985 diamines Chemical class 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 abstract 1
- 229910000041 hydrogen chloride Inorganic materials 0.000 abstract 1
- 150000002518 isoindoles Chemical class 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- -1 organometallic phenyl compound Chemical class 0.000 abstract 1
- 239000007800 oxidant agent Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- MUMZUERVLWJKNR-UHFFFAOYSA-N oxoplatinum Chemical compound [Pt]=O MUMZUERVLWJKNR-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229910003446 platinum oxide Inorganic materials 0.000 abstract 1
- 239000003368 psychostimulant agent Substances 0.000 abstract 1
- XJDNKRIXUMDJCW-UHFFFAOYSA-J titanium tetrachloride Chemical compound Cl[Ti](Cl)(Cl)Cl XJDNKRIXUMDJCW-UHFFFAOYSA-J 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
- C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/41—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by hydrogenolysis or reduction of carboxylic groups or functional derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/347—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups
- C07C51/363—Preparation of carboxylic acids or their salts, halides or anhydrides by reactions not involving formation of carboxyl groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D233/22—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62696567A | 1967-03-30 | 1967-03-30 | |
| US62996567A | 1967-03-30 | 1967-03-30 | |
| US639315A US3888846A (en) | 1967-03-30 | 1967-05-18 | Process for 2(2-(1,3-diazacycloalk-2-enyl))benzophenone derivatives and 1,3-diazacycloalkenyl(2,1-a)isoindole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1191237A true GB1191237A (en) | 1970-05-13 |
Family
ID=27417410
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB04967/68A Expired GB1191237A (en) | 1967-03-30 | 1968-03-28 | 0,3-Diazacyclo alkeno[2,1-a]isoindole Derivatives and a process for the mnufacture thereof |
| GB28271/69A Expired GB1191238A (en) | 1967-03-30 | 1968-03-28 | Substituted-Benzaldehydes |
| GB28273/69A Expired GB1191240A (en) | 1967-03-30 | 1968-03-28 | 0,3-Diazacycloalkeno[2,1-a]isoindolones |
| GB28272/69A Expired GB1191239A (en) | 1967-03-30 | 1968-03-28 | Hydroperoxy-Substituted 1,3-Diazacycloalkeno[2,1-a]isoindole Derivatives |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB28271/69A Expired GB1191238A (en) | 1967-03-30 | 1968-03-28 | Substituted-Benzaldehydes |
| GB28273/69A Expired GB1191240A (en) | 1967-03-30 | 1968-03-28 | 0,3-Diazacycloalkeno[2,1-a]isoindolones |
| GB28272/69A Expired GB1191239A (en) | 1967-03-30 | 1968-03-28 | Hydroperoxy-Substituted 1,3-Diazacycloalkeno[2,1-a]isoindole Derivatives |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US3888846A (enExample) |
| BE (1) | BE712958A (enExample) |
| CH (2) | CH501643A (enExample) |
| DE (1) | DE1695228C2 (enExample) |
| FR (2) | FR1584998A (enExample) |
| GB (4) | GB1191237A (enExample) |
| NL (1) | NL162076C (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3717658A (en) * | 1968-03-07 | 1973-02-20 | Hoffmann La Roche | 3'-arylspiro(imidazolidine-2,1'-phthalan)and 2-(2'-(alpha-hydroxy-arylmethyl)-aryl)-2-imidazoline derivatives |
| DE1770009C2 (de) * | 1968-03-20 | 1987-04-16 | American Home Products Corp., New York, N.Y. | Verfahren zur Herstellung von Imidazolinyl-Verbindungen |
| US3935218A (en) * | 1968-09-05 | 1976-01-27 | American Home Products Corporation | Imidazolinyl phenyl carbonyl compounds acid addition salts and related compounds |
| CH530980A (de) * | 1969-03-05 | 1972-11-30 | Sandoz Ag | Verfahren zur Herstellung von Imidazo(2,1-a)isoindolen |
| CY786A (en) * | 1970-02-12 | 1976-06-01 | American Home Prod | Novel imidazoline derivatives |
| GB1366133A (en) * | 1971-01-11 | 1974-09-11 | Wyeth John & Brother Ltd | Fused ring indole derivatives |
| GB1476464A (en) * | 1974-11-20 | 1977-06-16 | Wyeth John & Brother Ltd | 9-tetrahydropyrimidinyl-and 9-imidazolinyl-fluorenols their preparation and their pharmaceutical compositions |
| DE3403730A1 (de) * | 1984-02-03 | 1985-08-08 | Hoechst Ag, 6230 Frankfurt | Isoindole, verfahren zu ihrer herstellung und ihre verwendung in der landwirtschaft |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3379733A (en) * | 1965-12-07 | 1968-04-23 | Sandoz Ag | N-(omega-aminoalkyl)isoindoles and method for preparing same |
-
1967
- 1967-05-18 US US639315A patent/US3888846A/en not_active Expired - Lifetime
-
1968
- 1968-03-15 CH CH390068A patent/CH501643A/de not_active IP Right Cessation
- 1968-03-15 CH CH1720970A patent/CH510673A/de not_active IP Right Cessation
- 1968-03-19 DE DE1695228A patent/DE1695228C2/de not_active Expired
- 1968-03-28 GB GB04967/68A patent/GB1191237A/en not_active Expired
- 1968-03-28 GB GB28271/69A patent/GB1191238A/en not_active Expired
- 1968-03-28 GB GB28273/69A patent/GB1191240A/en not_active Expired
- 1968-03-28 GB GB28272/69A patent/GB1191239A/en not_active Expired
- 1968-03-29 BE BE712958D patent/BE712958A/xx not_active IP Right Cessation
- 1968-03-29 NL NL6804450.A patent/NL162076C/xx not_active IP Right Cessation
- 1968-03-29 FR FR1584998D patent/FR1584998A/fr not_active Expired
- 1968-03-29 FR FR146548A patent/FR8391M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1191239A (en) | 1970-05-13 |
| GB1191240A (en) | 1970-05-13 |
| GB1191238A (en) | 1970-05-13 |
| DE1695228A1 (de) | 1971-04-08 |
| US3888846A (en) | 1975-06-10 |
| NL162076B (nl) | 1979-11-15 |
| CH501643A (de) | 1971-01-15 |
| NL6804450A (enExample) | 1968-10-01 |
| NL162076C (nl) | 1980-04-15 |
| DE1695228C2 (de) | 1984-02-16 |
| FR8391M (enExample) | 1971-03-31 |
| BE712958A (enExample) | 1968-09-30 |
| FR1584998A (enExample) | 1970-01-09 |
| CH510673A (de) | 1971-07-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLE | Entries relating assignments, transmissions, licences in the register of patents |