GB1183135A - 2,4-Benzodiazepines, process for their manufacture and Compositions containing them - Google Patents
2,4-Benzodiazepines, process for their manufacture and Compositions containing themInfo
- Publication number
- GB1183135A GB1183135A GB1694368A GB1694368A GB1183135A GB 1183135 A GB1183135 A GB 1183135A GB 1694368 A GB1694368 A GB 1694368A GB 1694368 A GB1694368 A GB 1694368A GB 1183135 A GB1183135 A GB 1183135A
- Authority
- GB
- United Kingdom
- Prior art keywords
- aliphatic
- araliphatic
- heteroaryl
- aromatic
- residue
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- SEADJJCWSPCSHY-UHFFFAOYSA-N 2h-2,4-benzodiazepine Chemical class N1C=NC=C2C=CC=CC2=C1 SEADJJCWSPCSHY-UHFFFAOYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- -1 araliphatic Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 3
- 125000001072 heteroaryl group Chemical group 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 abstract 1
- DNOLEPJCJHUZAH-UHFFFAOYSA-N 2-[2-methyl-6-(nitromethyl)phenyl]isoindole-1,3-dione Chemical compound [N+](=O)([O-])CC1=C(C(=CC=C1)C)N1C(C=2C(C1=O)=CC=CC2)=O DNOLEPJCJHUZAH-UHFFFAOYSA-N 0.000 abstract 1
- YASNOOXSTVLJSK-UHFFFAOYSA-N 2-[[2-(bromomethyl)phenyl]methyl]isoindole-1,3-dione Chemical compound BrCC1=CC=CC=C1CN1C(=O)C2=CC=CC=C2C1=O YASNOOXSTVLJSK-UHFFFAOYSA-N 0.000 abstract 1
- QWFVUWYFEIHZTO-UHFFFAOYSA-N 2-[[2-[(1,3-dioxoisoindol-2-yl)methyl]phenyl]methyl]isoindole-1,3-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1CC1=CC=CC=C1CN1C(=O)C2=CC=CC=C2C1=O QWFVUWYFEIHZTO-UHFFFAOYSA-N 0.000 abstract 1
- JWUJZBXFQJRJQN-UHFFFAOYSA-N 3-[2-(aminomethyl)phenyl]propanimidamide Chemical compound NCC1=CC=CC=C1CCC(N)=N JWUJZBXFQJRJQN-UHFFFAOYSA-N 0.000 abstract 1
- ARDGNESPSBMETM-UHFFFAOYSA-N N'-[[2-(nitromethyl)phenyl]methyl]ethanimidamide Chemical compound [N+](=O)([O-])CC1=C(CNC(C)=N)C=CC=C1 ARDGNESPSBMETM-UHFFFAOYSA-N 0.000 abstract 1
- 150000001204 N-oxides Chemical class 0.000 abstract 1
- GKXVJHDEWHKBFH-UHFFFAOYSA-N [2-(aminomethyl)phenyl]methanamine Chemical compound NCC1=CC=CC=C1CN GKXVJHDEWHKBFH-UHFFFAOYSA-N 0.000 abstract 1
- YWWPCKHVIQGQTB-UHFFFAOYSA-N [2-(nitromethyl)phenyl]methanamine Chemical compound [N+](=O)([O-])CC1=C(CN)C=CC=C1 YWWPCKHVIQGQTB-UHFFFAOYSA-N 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 239000002269 analeptic agent Substances 0.000 abstract 1
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 abstract 1
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003224 coccidiostatic agent Substances 0.000 abstract 1
- 230000002526 effect on cardiovascular system Effects 0.000 abstract 1
- 125000001841 imino group Chemical group [H]N=* 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/04—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US63049767A | 1967-04-13 | 1967-04-13 | |
| US69442167A | 1967-12-29 | 1967-12-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1183135A true GB1183135A (en) | 1970-03-04 |
Family
ID=27091165
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1694368A Expired GB1183135A (en) | 1967-04-13 | 1968-04-09 | 2,4-Benzodiazepines, process for their manufacture and Compositions containing them |
Country Status (5)
| Country | Link |
|---|---|
| BE (1) | BE713698A (enExample) |
| CH (3) | CH527828A (enExample) |
| DE (1) | DE1770135A1 (enExample) |
| FR (2) | FR1588463A (enExample) |
| GB (1) | GB1183135A (enExample) |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU639821B2 (en) * | 1990-09-10 | 1993-08-05 | Sanofi | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents |
| EP0597540A1 (en) * | 1992-11-10 | 1994-05-18 | Sterling Winthrop Inc. | Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents |
| US5380721A (en) * | 1990-09-10 | 1995-01-10 | Sterling Winthrop Inc. | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents |
| WO1996019440A1 (en) * | 1994-12-20 | 1996-06-27 | The Wellcome Foundation Limited | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase |
| JP2009513656A (ja) * | 2005-10-27 | 2009-04-02 | シェーリング コーポレイション | 複素環式アスパルチルプロテアーゼインヒビター |
| CN101671307A (zh) * | 2003-12-15 | 2010-03-17 | 先灵公司 | 杂环天冬氨酰蛋白酶抑制剂 |
-
1968
- 1968-03-25 CH CH258071A patent/CH527828A/de not_active IP Right Cessation
- 1968-03-25 CH CH435768A patent/CH511863A/de not_active IP Right Cessation
- 1968-03-25 CH CH257971A patent/CH523264A/de not_active IP Right Cessation
- 1968-04-05 DE DE19681770135 patent/DE1770135A1/de active Pending
- 1968-04-09 GB GB1694368A patent/GB1183135A/en not_active Expired
- 1968-04-11 FR FR1588463D patent/FR1588463A/fr not_active Expired
- 1968-04-12 BE BE713698D patent/BE713698A/xx unknown
- 1968-07-02 FR FR157515A patent/FR7495M/fr not_active Expired
Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU639821B2 (en) * | 1990-09-10 | 1993-08-05 | Sanofi | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents |
| US5380721A (en) * | 1990-09-10 | 1995-01-10 | Sterling Winthrop Inc. | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents |
| US5624922A (en) * | 1990-09-10 | 1997-04-29 | Sterling Winthrop Inc. | Aryl-fused and hetaryl-fused-2,4-diazepine and 2,4-diazocine antiarrhythmic agents |
| EP0597540A1 (en) * | 1992-11-10 | 1994-05-18 | Sterling Winthrop Inc. | Aryl-fused and hetaryl-fused-2,4-diazocine antiarrhythmic agents |
| WO1996019440A1 (en) * | 1994-12-20 | 1996-06-27 | The Wellcome Foundation Limited | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase |
| US5866612A (en) * | 1994-12-20 | 1999-02-02 | Glaxo Wellcome Inc. | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase |
| USRE37438E1 (en) | 1994-12-20 | 2001-11-06 | Glaxo Wellcome Inc. | Acetamidine derivatives and their use as inhibitors for the nitric oxide synthase |
| CN101671307A (zh) * | 2003-12-15 | 2010-03-17 | 先灵公司 | 杂环天冬氨酰蛋白酶抑制剂 |
| CN102627609A (zh) * | 2003-12-15 | 2012-08-08 | 先灵公司 | 杂环天冬氨酰蛋白酶抑制剂 |
| CN101671307B (zh) * | 2003-12-15 | 2014-05-14 | 默沙东公司 | 杂环天冬氨酰蛋白酶抑制剂 |
| CN102627609B (zh) * | 2003-12-15 | 2016-05-04 | 默沙东公司 | 杂环天冬氨酰蛋白酶抑制剂 |
| JP2009513656A (ja) * | 2005-10-27 | 2009-04-02 | シェーリング コーポレイション | 複素環式アスパルチルプロテアーゼインヒビター |
Also Published As
| Publication number | Publication date |
|---|---|
| CH511863A (de) | 1971-08-31 |
| FR1588463A (enExample) | 1970-04-17 |
| CH527828A (de) | 1972-09-15 |
| BE713698A (enExample) | 1968-10-14 |
| DE1770135A1 (de) | 1971-09-23 |
| FR7495M (enExample) | 1969-12-08 |
| CH523264A (de) | 1972-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |