GB1179131A - Process for the Preparation of Erythrocytes Suitable for Immunochemical Determinations and the Manufacture of Dosage Unit Forms therefrom. - Google Patents

Process for the Preparation of Erythrocytes Suitable for Immunochemical Determinations and the Manufacture of Dosage Unit Forms therefrom.

Info

Publication number
GB1179131A
GB1179131A GB03515/67A GB1351567A GB1179131A GB 1179131 A GB1179131 A GB 1179131A GB 03515/67 A GB03515/67 A GB 03515/67A GB 1351567 A GB1351567 A GB 1351567A GB 1179131 A GB1179131 A GB 1179131A
Authority
GB
United Kingdom
Prior art keywords
erythrocytes
hcg
preparation
march
manufacture
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB03515/67A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Organon Laboratories Ltd
Original Assignee
Organon Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Organon Laboratories Ltd filed Critical Organon Laboratories Ltd
Publication of GB1179131A publication Critical patent/GB1179131A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
    • G01N33/555—Red blood cell
    • G01N33/556—Fixed or stabilised red blood cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G01N33/76—Human chorionic gonadotropin including luteinising hormone, follicle stimulating hormone, thyroid stimulating hormone or their receptors
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/815—Test for named compound or class of compounds
    • Y10S436/817—Steroids or hormones
    • Y10S436/818—Human chorionic gonadotropin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Mycology (AREA)
  • Reproductive Health (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

1,179,131. Reagent for HCG determination, ORGANON LABORATORIES Ltd. 22 March, 1967 [24 March, 1966], No. 13515/67. Heading B1X. A process for the preparation of erythrocytes for the immunochemical determination of human chorionic gonadotrophin (HCG) comprises treating the erythrocytes with one or more tanning agents and then sensitizing the erythrocytes by treatment with HCG, the sensitization being carried out for at least the last 12 hours of the total sensitization time in the presence of formaldehyde in a concentration below 2% w/v and at a pH between 5.5 and 8. The resulting suspension may be freeze- or spray-dried and the dry powder may be tableted with fillers, for example saccharose, manitol, lactose or urea; lubricants, for example boric acid, starch, Carbowax (RTM), magnesium stearate; disintegration agents, for example starch, alginic acid; phosphate buffers; sodium chloride; disodium EDTA; albumin. Examples refer to sheep erythrocytes treated with formalin and tannin.
GB03515/67A 1966-03-24 1967-03-22 Process for the Preparation of Erythrocytes Suitable for Immunochemical Determinations and the Manufacture of Dosage Unit Forms therefrom. Expired GB1179131A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
NL6603909A NL6603909A (en) 1966-03-24 1966-03-24

Publications (1)

Publication Number Publication Date
GB1179131A true GB1179131A (en) 1970-01-28

Family

ID=19796083

Family Applications (1)

Application Number Title Priority Date Filing Date
GB03515/67A Expired GB1179131A (en) 1966-03-24 1967-03-22 Process for the Preparation of Erythrocytes Suitable for Immunochemical Determinations and the Manufacture of Dosage Unit Forms therefrom.

Country Status (12)

Country Link
US (1) US3548051A (en)
AT (1) AT270864B (en)
BE (1) BE696050A (en)
CH (1) CH508390A (en)
DE (1) DE1617672A1 (en)
DK (1) DK126452B (en)
ES (1) ES338201A1 (en)
GB (1) GB1179131A (en)
GR (1) GR36578B (en)
IL (1) IL27578A (en)
NL (2) NL6603909A (en)
SE (1) SE335592B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0356258A2 (en) * 1988-08-26 1990-02-28 Cryopharm Corporation Processes for the lyophilization of red blood cells, together with media for lyophilization
US5340592A (en) * 1988-05-18 1994-08-23 Cobe Laboratories, Inc. Lyophilization of erythrocytes
US5425951A (en) * 1988-05-18 1995-06-20 Cryopharm Corporation Method of reconstituting lyophilized cells

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3655838A (en) * 1969-03-20 1972-04-11 Organon Method of pelletizing analytical or immunological reagents
DE2310964A1 (en) * 1973-03-02 1974-09-05 Schering Ag ANTIGEN OR ANTIGEN PROTEIN CONJUGATE COATED ERYTHROCYTE PREPARATION
US4136161A (en) * 1976-03-16 1979-01-23 Ortho Diagnostics, Inc. Stabilized erythrocytes and methods therefor
JPS55162059A (en) * 1979-06-05 1980-12-17 Mochida Pharmaceut Co Ltd Measuring method for antigen, antibody or their complex and measurement reagent kit
US4282002A (en) * 1979-09-06 1981-08-04 Akzona Incorporated Sensitized sheep stroma immunoassay for rheumatoid factor
FR2476320B1 (en) * 1980-02-15 1985-10-25 Guffroy Rene NOVEL IMMUNOLOGICAL REAGENT FOR THE DETECTION IN TUBES OF THE RHUMATOID FACTOR IN A BIOLOGICAL SAMPLE AND METHOD FOR PREPARING THIS NEW REAGENT
US4609630A (en) * 1983-03-23 1986-09-02 Yanovsky Jorge F Method for improving the specificity of immunoassays
US7935478B2 (en) * 2004-02-02 2011-05-03 Core Dynamics Limited Biological material and methods and solutions for preservation thereof
JP7110360B2 (en) 2017-10-09 2022-08-01 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー Freeze-drying method
JP7471316B2 (en) 2019-03-14 2024-04-19 テルモ ビーシーティー バイオテクノロジーズ，エルエルシー Multi-part freeze-drying container

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3096250A (en) * 1959-11-30 1963-07-02 Indiana University Foundation Novel particulate antigens and process
US3236732A (en) * 1962-01-22 1966-02-22 Edward R Arquilla Pregnancy test method and immunological indicator therefor

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5340592A (en) * 1988-05-18 1994-08-23 Cobe Laboratories, Inc. Lyophilization of erythrocytes
US5425951A (en) * 1988-05-18 1995-06-20 Cryopharm Corporation Method of reconstituting lyophilized cells
EP0356258A2 (en) * 1988-08-26 1990-02-28 Cryopharm Corporation Processes for the lyophilization of red blood cells, together with media for lyophilization
EP0356258A3 (en) * 1988-08-26 1990-06-06 Cryopharm Corporation Processes for the lyophilization of red blood cells, together with media for lyophilization
US5648206A (en) * 1988-08-26 1997-07-15 Cobe Laboratories, Inc. Lyophilization of cells

Also Published As

Publication number Publication date
ES338201A1 (en) 1968-04-01
CH508390A (en) 1971-06-15
BE696050A (en) 1967-09-25
US3548051A (en) 1970-12-15
NL6603909A (en) 1967-09-25
AT270864B (en) 1969-05-12
DK126452B (en) 1973-07-16
SE335592B (en) 1971-06-01
NL126572C (en)
IL27578A (en) 1971-04-28
DE1617672A1 (en) 1971-04-01
GR36578B (en) 1969-02-21

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