GB1177525A - New Heterocyclic Aminoketones of Therapeutic Interest - Google Patents
New Heterocyclic Aminoketones of Therapeutic InterestInfo
- Publication number
- GB1177525A GB1177525A GB07115/67A GB1711567A GB1177525A GB 1177525 A GB1177525 A GB 1177525A GB 07115/67 A GB07115/67 A GB 07115/67A GB 1711567 A GB1711567 A GB 1711567A GB 1177525 A GB1177525 A GB 1177525A
- Authority
- GB
- United Kingdom
- Prior art keywords
- prepared
- methyl
- phenyl
- compound
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Heterocyclic Aminoketones Chemical class 0.000 title abstract 3
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000002253 acid Substances 0.000 abstract 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- 150000003839 salts Chemical class 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000011230 binding agent Substances 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- NTRATOUBIPAKPQ-UHFFFAOYSA-N 2-(bromomethyl)-2-phenyl-1,3-dioxolane Chemical compound C=1C=CC=CC=1C1(CBr)OCCO1 NTRATOUBIPAKPQ-UHFFFAOYSA-N 0.000 abstract 1
- HBGZNAVMMDXNFX-UHFFFAOYSA-N 3-(5,6-dihydrobenzo[b][1]benzazepin-11-yl)propyl 4-methylbenzenesulfonate Chemical compound C1(=CC=C(C=C1)S(=O)(=O)OCCCN1C2=C(CCC3=C1C=CC=C3)C=CC=C2)C HBGZNAVMMDXNFX-UHFFFAOYSA-N 0.000 abstract 1
- KRGXWTOLFOPIKV-UHFFFAOYSA-N 3-(methylamino)propan-1-ol Chemical compound CNCCCO KRGXWTOLFOPIKV-UHFFFAOYSA-N 0.000 abstract 1
- YYROPELSRYBVMQ-UHFFFAOYSA-N 4-toluenesulfonyl chloride Chemical compound CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 abstract 1
- FCSKOFQQCWLGMV-UHFFFAOYSA-N 5-{5-[2-chloro-4-(4,5-dihydro-1,3-oxazol-2-yl)phenoxy]pentyl}-3-methylisoxazole Chemical compound O1N=C(C)C=C1CCCCCOC1=CC=C(C=2OCCN=2)C=C1Cl FCSKOFQQCWLGMV-UHFFFAOYSA-N 0.000 abstract 1
- DRSHXJFUUPIBHX-UHFFFAOYSA-N COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 Chemical compound COc1ccc(cc1)N1N=CC2C=NC(Nc3cc(OC)c(OC)c(OCCCN4CCN(C)CC4)c3)=NC12 DRSHXJFUUPIBHX-UHFFFAOYSA-N 0.000 abstract 1
- NCJCWVLPZRBVQL-UHFFFAOYSA-N Cl.CN(CCCCl)CC(C1=CC=CC=C1)=O Chemical compound Cl.CN(CCCCl)CC(C1=CC=CC=C1)=O NCJCWVLPZRBVQL-UHFFFAOYSA-N 0.000 abstract 1
- YTUJYNAMYYOYQI-UHFFFAOYSA-N N,4-dimethyl-2-phenyl-1,3-dioxolan-2-amine Chemical compound CNC1(OCC(O1)C)C1=CC=CC=C1 YTUJYNAMYYOYQI-UHFFFAOYSA-N 0.000 abstract 1
- NZKPMWWUTNJZCV-UHFFFAOYSA-N N-(3-hydroxybutyl)-N-methylbenzamide Chemical compound CN(CCC(O)C)C(C1=CC=CC=C1)=O NZKPMWWUTNJZCV-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 125000002541 furyl group Chemical group 0.000 abstract 1
- 239000000543 intermediate Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 125000001544 thienyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/28—Radicals substituted by nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Priority Applications (16)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB07115/67A GB1177525A (en) | 1967-04-13 | 1967-04-13 | New Heterocyclic Aminoketones of Therapeutic Interest |
| IS1733A IS815B6 (is) | 1967-04-13 | 1968-03-30 | Heterocykliskar aminoketoner, - aðferð til framleiðslu - |
| NO131368A NO126622B (https=) | 1967-04-13 | 1968-04-04 | |
| SE4669/68A SE344199B (https=) | 1967-04-13 | 1968-04-05 | |
| FI680940A FI49307C (fi) | 1967-04-13 | 1968-04-05 | Menetelmä uusien farmakologisesti arvokkaiden heterosyklisten aminoket onien valmistamiseksi. |
| DE1770153A DE1770153C3 (de) | 1967-04-13 | 1968-04-08 | Heterocyclische Aminoketone, deren pharmakologisch verträgliche Säureadditionssalze und Verfahren zu ihrer Herstellung |
| US719665A US3637660A (en) | 1967-04-13 | 1968-04-08 | Dibenzazepine derivatives |
| CA017072A CA925505A (en) | 1967-04-13 | 1968-04-09 | Heterocyclic aminoketones of therapeutic interest |
| AT356068A AT287000B (de) | 1967-04-13 | 1968-04-10 | Verfahren zur Herstellung von neuen heterocyclischen Aminoketonen und ihren Salzen |
| CH536268A CH500195A (de) | 1967-04-13 | 1968-04-10 | Verfahren zur Herstellung von neuen pharmakologisch wirksamen heterocyclischen Aminoketonen |
| NL6805201.A NL159094B (nl) | 1967-04-13 | 1968-04-11 | Werkwijze voor het bereiden van preparaten met een anti-depressieve activiteit op het centrale zenuwstelsel, aldus verkregen gevormd preparaat, alsmede werkwijze voor het bereiden van daarvoor geschikte geneeskrachtige verbindingen. |
| ES352680A ES352680A1 (es) | 1967-04-13 | 1968-04-11 | Un procedimiento para la preparacion de nuevas aminocetonasheterociclicas farmaceuticamente valiosas. |
| FR148101A FR7476M (https=) | 1967-04-13 | 1968-04-12 | |
| BE713623D BE713623A (https=) | 1967-04-13 | 1968-04-12 | |
| FR1590128D FR1590128A (https=) | 1967-04-13 | 1968-07-12 | |
| US00185879A US3833567A (en) | 1967-04-13 | 1971-10-01 | Phenothiazines |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB07115/67A GB1177525A (en) | 1967-04-13 | 1967-04-13 | New Heterocyclic Aminoketones of Therapeutic Interest |
| US00185879A US3833567A (en) | 1967-04-13 | 1971-10-01 | Phenothiazines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1177525A true GB1177525A (en) | 1970-01-14 |
Family
ID=26252483
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB07115/67A Expired GB1177525A (en) | 1967-04-13 | 1967-04-13 | New Heterocyclic Aminoketones of Therapeutic Interest |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3637660A (https=) |
| AT (1) | AT287000B (https=) |
| BE (1) | BE713623A (https=) |
| CA (1) | CA925505A (https=) |
| CH (1) | CH500195A (https=) |
| DE (1) | DE1770153C3 (https=) |
| FI (1) | FI49307C (https=) |
| FR (2) | FR7476M (https=) |
| GB (1) | GB1177525A (https=) |
| NL (1) | NL159094B (https=) |
| SE (1) | SE344199B (https=) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2628558A1 (de) * | 1975-07-03 | 1977-01-20 | Leo Ab | Verfahren zur herstellung von lofepraminhydrochlorid |
| US4061747A (en) | 1975-07-03 | 1977-12-06 | Aktiebolaget Leo | Antidepressant composition |
| EP1357117A3 (en) * | 2002-04-26 | 2003-12-17 | Chingfan Chris Chiu | Novel aminoketone derivatives and preparation process and uses of the same as photoinitiators |
| EP2343073A2 (en) | 2003-12-11 | 2011-07-13 | Sepracor Inc. | Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression |
| EP2385944A4 (en) * | 2009-01-09 | 2013-06-19 | Harvard College | FLUORINARY COMPOUNDS AND METHOD OF USE THEREOF |
| US8686158B2 (en) | 2008-06-05 | 2014-04-01 | President And Fellows Of Harvard College | High-valent palladium fluoride complexes and uses thereof |
| US9024093B2 (en) | 2008-11-20 | 2015-05-05 | President And Fellows Of Harvard College | Fluorination of organic compounds |
| US9150516B2 (en) | 2011-04-12 | 2015-10-06 | President And Fellows Of Harvard College | Fluorination of organic compounds |
| US9273083B2 (en) | 2012-09-26 | 2016-03-01 | President And Fellows Of Harvard College | Nickel fluorinating complexes and uses thereof |
| US10759764B2 (en) | 2013-10-18 | 2020-09-01 | President And Fellows Of Harvard College | Fluorination of organic compounds |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3846409A (en) * | 1971-03-22 | 1974-11-05 | Syntex Inc | 10,11-METHANO 5H-DIBENZ {8 b,f{9 {0 AZEPINES 5-PHENACYL DERIVATIVES |
| US4021552A (en) * | 1975-06-27 | 1977-05-03 | A. H. Robins Company, Incorporated | 10-[ω-(BENZOYLPIPERIDINYL)ALKYL]PHENOTHIAZINES |
| FR2316956A1 (fr) * | 1975-07-10 | 1977-02-04 | Roussel Uclaf | Nouveaux derives des 4h-thieno-3,2-b-1-benzazepines et leurs sels, procede de preparation et application a titre de medicaments |
| US4256743A (en) * | 1979-02-22 | 1981-03-17 | President And Fellows Of Harvard College | Inhibition of bone resorption with H1 -blocking antihistamines |
| DE3604325A1 (de) * | 1986-02-12 | 1987-08-13 | Ulrich Kreusel | Kreuzverbinder fuer zwei sich kreuzende rohre |
| DE4108119A1 (de) * | 1991-03-13 | 1992-09-17 | Jellalabad Ltd | Verfahren zur herstellung von 4'-chlor-2-((3-(10,11-dihydro-5h-dibenz(b,f)azepin-5-yl)propyl) methylaminno) acetophenon und seiner salze, die stabilisierungseiner salze, hierbei erhaeltliche produkte und pharmmazeutische zubereitungen, die diese enthalten |
| NZ545494A (en) | 2003-09-12 | 2009-10-30 | Pfizer | Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors |
| WO2007056457A2 (en) | 2005-11-09 | 2007-05-18 | Combinatorx, Incorporated | Methods, compositions, and kits for the treatment of medical conditions |
| US20080161324A1 (en) * | 2006-09-14 | 2008-07-03 | Johansen Lisa M | Compositions and methods for treatment of viral diseases |
| AU2008331868B2 (en) * | 2007-11-28 | 2015-02-12 | Nektar Therapeutics | Oligomer-tricyclic conjugates |
| WO2011091050A1 (en) | 2010-01-19 | 2011-07-28 | Nektar Therapeutics | Oligomer-tricyclic conjugates |
| EP2648707B1 (en) | 2010-12-10 | 2016-05-11 | Nektar Therapeutics | Hydroxylated tricyclic compounds |
-
1967
- 1967-04-13 GB GB07115/67A patent/GB1177525A/en not_active Expired
-
1968
- 1968-04-05 SE SE4669/68A patent/SE344199B/xx unknown
- 1968-04-05 FI FI680940A patent/FI49307C/fi active
- 1968-04-08 DE DE1770153A patent/DE1770153C3/de not_active Expired
- 1968-04-08 US US719665A patent/US3637660A/en not_active Expired - Lifetime
- 1968-04-09 CA CA017072A patent/CA925505A/en not_active Expired
- 1968-04-10 AT AT356068A patent/AT287000B/de not_active IP Right Cessation
- 1968-04-10 CH CH536268A patent/CH500195A/de not_active IP Right Cessation
- 1968-04-11 NL NL6805201.A patent/NL159094B/xx not_active IP Right Cessation
- 1968-04-12 FR FR148101A patent/FR7476M/fr not_active Expired
- 1968-04-12 BE BE713623D patent/BE713623A/xx not_active IP Right Cessation
- 1968-07-12 FR FR1590128D patent/FR1590128A/fr not_active Expired
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2628558A1 (de) * | 1975-07-03 | 1977-01-20 | Leo Ab | Verfahren zur herstellung von lofepraminhydrochlorid |
| US4061747A (en) | 1975-07-03 | 1977-12-06 | Aktiebolaget Leo | Antidepressant composition |
| US4172074A (en) * | 1975-07-03 | 1979-10-23 | Aktiebolaget Leo | Preparation of an antidepressant |
| EP1357117A3 (en) * | 2002-04-26 | 2003-12-17 | Chingfan Chris Chiu | Novel aminoketone derivatives and preparation process and uses of the same as photoinitiators |
| EP2343073A2 (en) | 2003-12-11 | 2011-07-13 | Sepracor Inc. | Combination of a sedative and a neurotransmitter modulator, and methods for improving sleep quality and treating depression |
| US8686158B2 (en) | 2008-06-05 | 2014-04-01 | President And Fellows Of Harvard College | High-valent palladium fluoride complexes and uses thereof |
| US9024093B2 (en) | 2008-11-20 | 2015-05-05 | President And Fellows Of Harvard College | Fluorination of organic compounds |
| EP2385944A4 (en) * | 2009-01-09 | 2013-06-19 | Harvard College | FLUORINARY COMPOUNDS AND METHOD OF USE THEREOF |
| US9150516B2 (en) | 2011-04-12 | 2015-10-06 | President And Fellows Of Harvard College | Fluorination of organic compounds |
| US9273083B2 (en) | 2012-09-26 | 2016-03-01 | President And Fellows Of Harvard College | Nickel fluorinating complexes and uses thereof |
| US10759764B2 (en) | 2013-10-18 | 2020-09-01 | President And Fellows Of Harvard College | Fluorination of organic compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| FR1590128A (https=) | 1970-04-13 |
| BE713623A (https=) | 1968-08-16 |
| NL6805201A (https=) | 1968-10-14 |
| SE344199B (https=) | 1972-04-04 |
| NL159094B (nl) | 1979-01-15 |
| CH500195A (de) | 1970-12-15 |
| DE1770153A1 (de) | 1971-09-30 |
| CA925505A (en) | 1973-05-01 |
| DE1770153C3 (de) | 1979-08-30 |
| DE1770153B2 (de) | 1978-12-21 |
| US3637660A (en) | 1972-01-25 |
| FR7476M (https=) | 1969-12-01 |
| FI49307C (fi) | 1975-05-12 |
| AT287000B (de) | 1971-01-11 |
| FI49307B (https=) | 1975-01-31 |
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