GB1119835A - Process for the preparation of basic ethers - Google Patents

Process for the preparation of basic ethers

Info

Publication number
GB1119835A
GB1119835A GB2939464A GB2939464A GB1119835A GB 1119835 A GB1119835 A GB 1119835A GB 2939464 A GB2939464 A GB 2939464A GB 2939464 A GB2939464 A GB 2939464A GB 1119835 A GB1119835 A GB 1119835A
Authority
GB
United Kingdom
Prior art keywords
group
aralkyl
alkyl
substituted
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2939464A
Inventor
Roland Yves Mauvernay
Norbert Busch
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ANALYSES ET DE RECH S BIOLOG M
Original Assignee
ANALYSES ET DE RECH S BIOLOG M
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ANALYSES ET DE RECH S BIOLOG M filed Critical ANALYSES ET DE RECH S BIOLOG M
Priority to GB2939464A priority Critical patent/GB1119835A/en
Priority to FR23256A priority patent/FR5012M/fr
Priority to CH953865A priority patent/CH447208A/en
Priority to BE666985D priority patent/BE666985A/xx
Priority to ES0315441A priority patent/ES315441A1/en
Priority to DE19651595882 priority patent/DE1595882A1/en
Publication of GB1119835A publication Critical patent/GB1119835A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C07C43/1742—Unsaturated ethers containing halogen containing six-membered aromatic rings with halogen atoms bound to the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/17—Unsaturated ethers containing halogen
    • C07C43/174—Unsaturated ethers containing halogen containing six-membered aromatic rings
    • C07C43/1745—Unsaturated ethers containing halogen containing six-membered aromatic rings having more than one ether bound
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/10—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/12—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Compounds of the general formula <FORM:1119835/C2/1> wherein A represents an alkyl, aryl, substituted aryl, aralkyl or substituted aralkyl group, a benzyloxymethyl group (in which the benzene ring may optionally be substituted by one or two halogen atoms, a trifluormethyl group or one or two methyl groups) or a benzhydryloxymethyl group (in which one of the benzene rings may optionally be substituted by one or two halogen atoms, a trifluoromethyl group or one or two methyl groups), R represents an alkyl, aralkyl or substituted aralkyl group or an alkyl group bearing a heterocyclic group and B represents an alkylamino, cycloalkylamino, alkenylamino, hydroxyalkylamino, aralkylamino, 1-pyrrolidinyl, piperidino or morpholino group, a 1-piperazinyl group (which may optionally be subtituted in the 4-position by an alkyl, aryl, aralkyl, diaralkyl, ar-haloaralkyl, haloalkyl, hydroxyalkyl, acyloxyalkyl, diaralkyloxyalkyl or ar-trimethoxybenzyl group) or a group of the formula-NR2R3 in which R2 and R3 are the same or different and each represents an alkyl, hydroxyalkyl, acyloxyalkyl or aralkyl group, and their acid addition and (in the case of tertiary amino compounds) quaternary ammonium salts are prepared by reacting ACH = CH2 with ROH in the presence of t-butyl hypobromite in the cold and heating the resulting ACH(OR)CH2Br with BH, optionally followed by salt formation.
GB2939464A 1964-07-20 1964-07-20 Process for the preparation of basic ethers Expired GB1119835A (en)

Priority Applications (6)

Application Number Priority Date Filing Date Title
GB2939464A GB1119835A (en) 1964-07-20 1964-07-20 Process for the preparation of basic ethers
FR23256A FR5012M (en) 1964-07-20 1965-07-02
CH953865A CH447208A (en) 1964-07-20 1965-07-07 Process for the preparation of new amines for pharmaceutical uses
BE666985D BE666985A (en) 1964-07-20 1965-07-16
ES0315441A ES315441A1 (en) 1964-07-20 1965-07-17 Process for the preparation of basic ethers
DE19651595882 DE1595882A1 (en) 1964-07-20 1965-07-20 Process for the preparation of new amine compounds as well as their addition salts and quaternary ammonium salts for pharmaceutical use

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB2939464A GB1119835A (en) 1964-07-20 1964-07-20 Process for the preparation of basic ethers

Publications (1)

Publication Number Publication Date
GB1119835A true GB1119835A (en) 1968-07-17

Family

ID=10290884

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2939464A Expired GB1119835A (en) 1964-07-20 1964-07-20 Process for the preparation of basic ethers

Country Status (6)

Country Link
BE (1) BE666985A (en)
CH (1) CH447208A (en)
DE (1) DE1595882A1 (en)
ES (1) ES315441A1 (en)
FR (1) FR5012M (en)
GB (1) GB1119835A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3026201A1 (en) * 1979-07-11 1981-02-26 Synthese Soc Ind Prod AMINOAETHEROXIDE, METHOD FOR THE PRODUCTION THEREOF AND THEIR THERAPEUTIC USE
US5750575A (en) * 1993-03-31 1998-05-12 Cell Therapeutics, Inc. Substituted amino alcohol compounds
JP2004506710A (en) * 2000-08-18 2004-03-04 ベーリンガー　インゲルハイム　ファルマ　ゲゼルシャフト　ミット　ベシュレンクテル　ハフツング　ウント　コンパニー　コマンディトゲゼルシャフト Phenyl- and phenylalkyl-substituted ethanolamines and ethylenediamines

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
YU41932B (en) * 1979-07-09 1988-02-29 Pfizer Process for obtaining substituted piperazines and piperidi
GB8316444D0 (en) * 1983-06-16 1983-07-20 Ici Plc Heterocycle compounds

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3026201A1 (en) * 1979-07-11 1981-02-26 Synthese Soc Ind Prod AMINOAETHEROXIDE, METHOD FOR THE PRODUCTION THEREOF AND THEIR THERAPEUTIC USE
US5750575A (en) * 1993-03-31 1998-05-12 Cell Therapeutics, Inc. Substituted amino alcohol compounds
JP2004506710A (en) * 2000-08-18 2004-03-04 ベーリンガー　インゲルハイム　ファルマ　ゲゼルシャフト　ミット　ベシュレンクテル　ハフツング　ウント　コンパニー　コマンディトゲゼルシャフト Phenyl- and phenylalkyl-substituted ethanolamines and ethylenediamines

Also Published As

Publication number Publication date
FR5012M (en) 1967-05-29
CH447208A (en) 1967-11-30
BE666985A (en) 1965-11-16
ES315441A1 (en) 1966-06-01
DE1595882A1 (en) 1969-12-11

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