GB1016668A - Novel benzodiazepinthiones and the preparation thereof - Google Patents

Novel benzodiazepinthiones and the preparation thereof

Info

Publication number
GB1016668A
GB1016668A GB37643/64A GB3764364A GB1016668A GB 1016668 A GB1016668 A GB 1016668A GB 37643/64 A GB37643/64 A GB 37643/64A GB 3764364 A GB3764364 A GB 3764364A GB 1016668 A GB1016668 A GB 1016668A
Authority
GB
United Kingdom
Prior art keywords
preparation
alkyl
benzodiazepinthiones
novel
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB37643/64A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of GB1016668A publication Critical patent/GB1016668A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/44—Iso-indoles; Hydrogenated iso-indoles
    • C07D209/48—Iso-indoles; Hydrogenated iso-indoles with oxygen atoms in positions 1 and 3, e.g. phthalimide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Indole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:1016668/C2/1> (wherein R1 and R2 are the same or different and each represents a C1- 7 alkyl group, R3 and R4 are the same or different and each represents a halogen atom or a trifluoromethyl, C1- 7 alkoxy, C1- 7 alkyl or di-(C1- 7 alkyl)amino group, and the broken lines denote optional substituents) and their preparation by reacting the corresponding benzodiazepinone-(2) with phosphorus pentasulphide.
GB37643/64A 1961-07-28 1962-07-27 Novel benzodiazepinthiones and the preparation thereof Expired GB1016668A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12749361A 1961-07-28 1961-07-28

Publications (1)

Publication Number Publication Date
GB1016668A true GB1016668A (en) 1966-01-12

Family

ID=22430433

Family Applications (3)

Application Number Title Priority Date Filing Date
GB37642/64A Expired GB1016667A (en) 1961-07-28 1962-07-27 Novel benzophenones and the preparation thereof
GB37643/64A Expired GB1016668A (en) 1961-07-28 1962-07-27 Novel benzodiazepinthiones and the preparation thereof
GB28946/62A Expired GB1017276A (en) 1961-07-28 1962-07-27 Novel 1,4-benzodiazepine derivatives

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB37642/64A Expired GB1016667A (en) 1961-07-28 1962-07-27 Novel benzophenones and the preparation thereof

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB28946/62A Expired GB1017276A (en) 1961-07-28 1962-07-27 Novel 1,4-benzodiazepine derivatives

Country Status (13)

Country Link
BE (1) BE620773A (en)
BR (1) BR6241300D0 (en)
CH (3) CH437319A (en)
CY (1) CY417A (en)
DE (2) DE1795542A1 (en)
DK (5) DK104106C (en)
ES (1) ES279766A1 (en)
FI (4) FI46621C (en)
GB (3) GB1016667A (en)
MY (1) MY6700029A (en)
NL (5) NL6909389A (en)
OA (1) OA02386A (en)
SE (7) SE301978B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104130201A (en) * 2014-07-14 2014-11-05 河南豫辰精细化工有限公司 Preparation method of benzodiazothioketone serving as intermediate of alprazolam

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003286755A1 (en) * 2002-10-30 2004-06-07 Smithkline Beecham Corporation Benzodiazepine derivatives for the treatment of diabetes mellitus

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104130201A (en) * 2014-07-14 2014-11-05 河南豫辰精细化工有限公司 Preparation method of benzodiazothioketone serving as intermediate of alprazolam
CN104130201B (en) * 2014-07-14 2016-06-01 河南豫辰药业股份有限公司 The preparation method of a kind of alprazolam intermediate benzodiazepine thioketones

Also Published As

Publication number Publication date
FI47773B (en) 1973-11-30
BE620773A (en) 1963-01-28
FI47372C (en) 1973-11-12
DE1445864A1 (en) 1969-01-16
SE304008B (en) 1968-09-16
NL6909390A (en) 1969-08-25
SE329399B (en) 1970-10-12
NL6909391A (en) 1969-08-25
DK104408C (en) 1966-05-16
FI47372B (en) 1973-07-31
NL6909392A (en) 1969-08-25
DK103023C (en) 1965-11-08
SE301978B (en) 1968-07-01
GB1017276A (en) 1966-01-19
DK106554C (en) 1967-02-20
DK102965C (en) 1965-11-01
FI47774C (en) 1974-03-11
NL136271C (en)
NL6909389A (en) 1969-08-25
FI47774B (en) 1973-11-30
DE1795542A1 (en) 1972-02-03
CH457463A (en) 1968-06-15
SE342630B (en) 1972-02-14
BR6241300D0 (en) 1973-08-09
CH458374A (en) 1968-06-30
ES279766A1 (en) 1963-01-16
FI46621B (en) 1973-01-31
FI46621C (en) 1973-05-08
DK104106C (en) 1966-04-04
SE304009B (en) 1968-09-16
MY6700029A (en) 1967-12-31
OA02386A (en) 1970-05-05
SE367404B (en) 1974-05-27
CH437319A (en) 1967-06-15
SE319183B (en) 1970-01-12
GB1016667A (en) 1966-01-12
FI47773C (en) 1974-03-11
CY417A (en) 1967-11-30

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