GB1107470A - Basic esters and a process for their production - Google Patents
Basic esters and a process for their productionInfo
- Publication number
- GB1107470A GB1107470A GB54090/66A GB5409066A GB1107470A GB 1107470 A GB1107470 A GB 1107470A GB 54090/66 A GB54090/66 A GB 54090/66A GB 5409066 A GB5409066 A GB 5409066A GB 1107470 A GB1107470 A GB 1107470A
- Authority
- GB
- United Kingdom
- Prior art keywords
- bis
- homopiperazine
- hydroxypropyl
- prepared
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000002148 esters Chemical class 0.000 title abstract 2
- -1 benzoyl halide Chemical class 0.000 abstract 4
- 125000003545 alkoxy group Chemical group 0.000 abstract 3
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- FQUYSHZXSKYCSY-UHFFFAOYSA-N 1,4-diazepane Chemical compound C1CNCCNC1 FQUYSHZXSKYCSY-UHFFFAOYSA-N 0.000 abstract 1
- GFDSJJUDNYNTKE-UHFFFAOYSA-N 3-[5-(3-hydroxypropyl)-1,5-diazocan-1-yl]propan-1-ol Chemical compound OCCCN1CCCN(CCC1)CCCO GFDSJJUDNYNTKE-UHFFFAOYSA-N 0.000 abstract 1
- QOXOZONBQWIKDA-UHFFFAOYSA-N 3-hydroxypropyl Chemical group [CH2]CCO QOXOZONBQWIKDA-UHFFFAOYSA-N 0.000 abstract 1
- WPYMKLBDIGXBTP-UHFFFAOYSA-N Benzoic acid Natural products OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 abstract 1
- 239000005711 Benzoic acid Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003513 alkali Substances 0.000 abstract 1
- 150000001447 alkali salts Chemical class 0.000 abstract 1
- 235000010233 benzoic acid Nutrition 0.000 abstract 1
- 150000001559 benzoic acids Chemical class 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000004985 diamines Chemical class 0.000 abstract 1
- 150000002391 heterocyclic compounds Chemical class 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- GGCZERPQGJTIQP-UHFFFAOYSA-N sodium;9,10-dioxoanthracene-2-sulfonic acid Chemical compound [Na+].C1=CC=C2C(=O)C3=CC(S(=O)(=O)O)=CC=C3C(=O)C2=C1 GGCZERPQGJTIQP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/08—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D245/00—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms
- C07D245/02—Heterocyclic compounds containing rings of more than seven members having two nitrogen atoms as the only ring hetero atoms not condensed with other rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE1965A0051095 DE1545575C2 (de) | 1965-12-16 | 1965-12-16 | N, N'-Bis- eckige Klammer auf 3"(3', 4', 5'-trimethoxybenzoyloxy)-propyl eckige Klammer zu -homopiperazin |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1107470A true GB1107470A (en) | 1968-03-27 |
Family
ID=6937763
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB54090/66A Expired GB1107470A (en) | 1965-12-16 | 1966-12-02 | Basic esters and a process for their production |
Country Status (14)
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0170361A1 (en) * | 1984-06-06 | 1986-02-05 | Kowa Company, Ltd. | Antiatherosclerotic agents |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3980643A (en) * | 1974-01-04 | 1976-09-14 | Hokuriku Pharmaceutical Co., Ltd. | Novel piperazine- and homopiperazine-monoalkanol esters and a process of production thereof |
| US4035494A (en) * | 1975-10-20 | 1977-07-12 | Sandoz, Inc. | Bis-p-pivaloyl benzylamines |
| DE3403778A1 (de) * | 1984-02-03 | 1985-08-08 | Degussa Ag, 6000 Frankfurt | Cyanomethyl-(2-cyano-ethyl)-(3-hydroxy-propyl)-amin seine verwendung zur herstellung von 1-(3-hydroxy-propyl)-1,4-diazepan und 1,4-bis(3-(3,4,5-trimethoxybenzoyloxy)-propyl)-diazepan |
| DE3438289A1 (de) * | 1984-10-19 | 1986-04-24 | Degussa Ag, 6000 Frankfurt | Verfahren zum reinigen von dilazep-base |
| EP1545519B1 (en) | 2002-08-19 | 2011-03-23 | Pfizer Inc. | Combination therapy for hyperproliferative diseases |
| US20060063803A1 (en) * | 2004-09-23 | 2006-03-23 | Pfizer Inc | 4-Amino substituted-2-substituted-1,2,3,4-tetrahydroquinoline compounds |
| US7741317B2 (en) | 2005-10-21 | 2010-06-22 | Bristol-Myers Squibb Company | LXR modulators |
| US7888376B2 (en) | 2005-11-23 | 2011-02-15 | Bristol-Myers Squibb Company | Heterocyclic CETP inhibitors |
| EP2094643B1 (en) | 2006-12-01 | 2012-02-29 | Bristol-Myers Squibb Company | N-((3-benzyl)-2,2-(bis-phenyl)-propan-1-amine derivatives as cetp inhibitors for the treatment of atherosclerosis and cardiovascular diseases |
| CN105143203A (zh) | 2013-04-17 | 2015-12-09 | 辉瑞大药厂 | 用于治疗心血管疾病的n-哌啶-3-基苯甲酰胺衍生物 |
| WO2016055901A1 (en) | 2014-10-08 | 2016-04-14 | Pfizer Inc. | Substituted amide compounds |
| ES3007652T3 (en) | 2019-01-18 | 2025-03-20 | Astrazeneca Ab | 6'-[[(1s,3s)-3-[[5-(difluoromethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2h),3'-bipyridin]-2-one as pcsk9 inhibitor and methods of use thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE629910A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1962-03-22 | |||
| DE1182239B (de) * | 1962-04-02 | 1964-11-26 | Lentia Gmbh | Verfahren zur Herstellung von Piperazinderivaten |
-
1965
- 1965-12-16 DE DE1965A0051095 patent/DE1545575C2/de not_active Expired
-
1966
- 1966-12-01 DK DK620966AA patent/DK113291B/da unknown
- 1966-12-02 GB GB54090/66A patent/GB1107470A/en not_active Expired
- 1966-12-05 AT AT1120566A patent/AT275527B/de active
- 1966-12-05 IL IL27013A patent/IL27013A/xx unknown
- 1966-12-07 US US599724A patent/US3532685A/en not_active Expired - Lifetime
- 1966-12-10 ES ES0334393A patent/ES334393A1/es not_active Expired
- 1966-12-12 SE SE17000/66A patent/SE317977B/xx unknown
- 1966-12-12 BE BE691016D patent/BE691016A/xx not_active IP Right Cessation
- 1966-12-14 CS CS668008A patent/CS191151B2/cs unknown
- 1966-12-15 NL NL666617653A patent/NL153537B/xx not_active IP Right Cessation
- 1966-12-15 CH CH1789566A patent/CH476742A/de not_active IP Right Cessation
- 1966-12-16 FR FR87720A patent/FR6053M/fr not_active Expired
-
1971
- 1971-12-31 MY MY197127A patent/MY7100027A/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0170361A1 (en) * | 1984-06-06 | 1986-02-05 | Kowa Company, Ltd. | Antiatherosclerotic agents |
Also Published As
| Publication number | Publication date |
|---|---|
| IL27013A (en) | 1970-07-19 |
| BE691016A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1967-06-12 |
| US3532685A (en) | 1970-10-06 |
| DE1545575C2 (de) | 1970-09-10 |
| NL153537B (nl) | 1977-06-15 |
| NL6617653A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1967-06-19 |
| SE317977B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1969-12-01 |
| FR6053M (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1968-05-20 |
| CH476742A (de) | 1969-08-15 |
| DK113291B (da) | 1969-03-10 |
| ES334393A1 (es) | 1967-11-01 |
| AT275527B (de) | 1969-10-27 |
| MY7100027A (en) | 1971-12-31 |
| DE1545575B1 (de) | 1970-02-05 |
| CS191151B2 (en) | 1979-06-29 |
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