GB1106093A - Chromatography of complex mixtures - Google Patents

Chromatography of complex mixtures

Info

Publication number
GB1106093A
GB1106093A GB13840/65A GB1384065A GB1106093A GB 1106093 A GB1106093 A GB 1106093A GB 13840/65 A GB13840/65 A GB 13840/65A GB 1384065 A GB1384065 A GB 1384065A GB 1106093 A GB1106093 A GB 1106093A
Authority
GB
United Kingdom
Prior art keywords
reservoirs
columns
pump
way valve
valve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB13840/65A
Inventor
Jiri Hrdina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Czech Academy of Sciences CAS
Original Assignee
Czech Academy of Sciences CAS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Czech Academy of Sciences CAS filed Critical Czech Academy of Sciences CAS
Publication of GB1106093A publication Critical patent/GB1106093A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/468—Flow patterns using more than one column involving switching between different column configurations
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/04—Preparation or injection of sample to be analysed
    • G01N30/24—Automatic injection systems
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/28—Control of physical parameters of the fluid carrier
    • G01N30/34—Control of physical parameters of the fluid carrier of fluid composition, e.g. gradient
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)

Abstract

1,106,093. Chromatography system. CESKOSLOVENSKA AKADEMIE VED. 1 April, 1965 [13 April, 1964], No. 13840/65. Heading B1X. An apparatus for chromatographic separation of mixtures for example mixtures of amino acids comprises a single pump (7 or P) to the inlet of which is connected a multiple way valve (8) having at least three inlets connected to at least two reservoirs (11-13) for eluting solutions and a reservoir (14) for regenerating solution and to the outlet of which is connected one or more columns (1, 2 or V, M), and at least two sample solution reservoirs (9 or 15) which may be connected upstream or downstream of the pump. The passages between the sample reservoirs and the columns are of capillary type. Where more than one column is employed, a valve (6), having a corresponding number of flow passages is used: a single column is directly connected (Fig. 7, not shown). The multiple-way valve may be replaced by at least two two-way valves interconnected by a common conduit (Fig. 3, not shown). The numerals refer to Figs. 1 and 4 (Fig. 4 omits integers upstream of the pump) in which the sample reservoirs are respectively open and pressurised. In each case, a second multiway valve 10 is provided for the reservoirs, and by suitably synchronising the rotation of valves 8, 10 and two-way valve 6, automatic separations of the various samples in sequence in predetermined columns with an elution, separation, elution regeneration cycle for each, may be effected. Other arrangements are described and illustrated.
GB13840/65A 1964-04-13 1965-04-01 Chromatography of complex mixtures Expired GB1106093A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CS213964 1964-04-13

Publications (1)

Publication Number Publication Date
GB1106093A true GB1106093A (en) 1968-03-13

Family

ID=5357648

Family Applications (1)

Application Number Title Priority Date Filing Date
GB13840/65A Expired GB1106093A (en) 1964-04-13 1965-04-01 Chromatography of complex mixtures

Country Status (5)

Country Link
US (1) US3373872A (en)
JP (1) JPS5247357B1 (en)
DE (1) DE1598205B1 (en)
GB (1) GB1106093A (en)
SE (1) SE305555B (en)

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DE1598212B2 (en) * 1964-05-26 1971-03-04 Ceskoslovenska akademie ved , Prag PROCESS AND EQUIPMENT FOR PREPARING DOSED MIXTURES
SE326056B (en) * 1966-01-07 1970-07-13 Ceskoslovenska Akademie Ved
US3446057A (en) * 1966-10-14 1969-05-27 Varian Associates Method and apparatus for chromatography
US3533933A (en) * 1967-03-31 1970-10-13 Hannig Kurt Process and device for the isolation of fractions of a substance mixture electrophoretically separated in a carrier gel
US3531258A (en) * 1967-11-16 1970-09-29 Us Health Education & Welfare Apparatus for the automated synthesis of peptides
US3514210A (en) * 1968-01-15 1970-05-26 Jiri Hrdina Device for programmed drawing off of gas bubbles from a measuring cell separator and the liquid from the extinction cell space
US3504799A (en) * 1968-04-02 1970-04-07 Beckman Instruments Inc Sample injector
US3575295A (en) * 1968-04-11 1971-04-20 Hitachi Ltd Sample introducing system for use in liquid chromatography
JPS4912401A (en) * 1972-05-17 1974-02-02
GB1441462A (en) * 1973-02-14 1976-06-30 Univ Edinburgh University Cour Method and apapratus for liquid chromotography
US3926809A (en) * 1973-10-10 1975-12-16 Roosevelt J Jones Multi-column fractionator
FR2279104A1 (en) * 1974-07-18 1976-02-13 Aquitaine Petrole LIQUID PHASE CHROMATOGRAPHY ANALYSIS PROCESS
US4112743A (en) * 1976-09-15 1978-09-12 Phillips Petroleum Company Step-wise gradient carrier for liquid chromatography
US4116046A (en) * 1977-08-05 1978-09-26 Hoffmann-La Roche Inc. Liquid chromatography system
US4219530A (en) * 1978-01-27 1980-08-26 Brinkmann Instruments, Inc. Apparatus for analyzing biological specimens
US4158630A (en) * 1978-02-24 1979-06-19 Stearns Stanley D Chromatographic multi-sample valving apparatus
US4204952A (en) * 1978-07-07 1980-05-27 Technicon Instruments Corporation Chromatographic apparatus and method
US4364263A (en) * 1980-09-15 1982-12-21 Burroughs Wellcome Co. High pressure liquid chromatographic system
EP0088439B1 (en) * 1982-03-10 1986-08-13 Hitachi, Ltd. Gas chromatographic apparatus
US5122275A (en) * 1986-05-08 1992-06-16 A. E. Staley Manufacturing Company Simulated moving bed chromatographic separation
US4950397A (en) * 1987-12-09 1990-08-21 Atlantic Richfield Company Apparatus for analyzing diluted and undiluted fluid samples
US4872992A (en) * 1987-12-09 1989-10-10 Atlantic Richfield Company Method and apparatus for analyzing diluted and undiluted fluid samples
JPH0746097B2 (en) * 1988-05-17 1995-05-17 三菱化成エンジニアリング株式会社 Chromatographic separation method
DE3907930C2 (en) * 1989-03-11 1994-02-24 Kabus Hans Peter Dr Buffer and reagent system for the separation of amino acids
US5089126A (en) * 1989-03-31 1992-02-18 Lehigh University Method and apparatus for capillary hydrodynamic fractionation
US5443734A (en) * 1990-03-05 1995-08-22 Applied Separations, Inc. Programmable solid phase extraction and elution device
US5071547A (en) * 1990-03-23 1991-12-10 Separations Technology, Inc. Column chromatographic column apparatus with switching capability
JP4067685B2 (en) * 1999-03-26 2008-03-26 山善株式会社 Injection device
US6318157B1 (en) 1999-04-23 2001-11-20 Advanced Bioanalytical Services, Inc. High-throughput parallel liquid chromatography system
US6581442B1 (en) * 1999-05-19 2003-06-24 Eisai Co., Ltd. Splitted tubing apparatus for gradient high performance liquid chromatography
JP2002035527A (en) * 2000-07-26 2002-02-05 Japan Atom Energy Res Inst Gas separation apparatus
US6701774B2 (en) * 2000-08-02 2004-03-09 Symyx Technologies, Inc. Parallel gas chromatograph with microdetector array
US6635173B2 (en) * 2000-12-28 2003-10-21 Cohesive Technologies, Inc. Multi column chromatography system
US7066011B2 (en) * 2001-06-07 2006-06-27 Nano Solution, Inc. Liquid chromatograph and analysis system
US6893569B2 (en) * 2003-06-16 2005-05-17 Sielc Technologies Method and apparatus for high pressure liquid chromatography
AU2003298273A1 (en) * 2003-11-05 2005-06-08 Agilent Technologies, Inc. Chromatography system
US8802035B2 (en) * 2005-06-21 2014-08-12 Waters Technologies Corporation Apparatus and methods for performing steps of a multi-step process in parallel
US20160001198A1 (en) * 2013-02-26 2016-01-07 The Translational Genomics Research Institute Mobile Phase Degassing for Nano-Flow Liquid Chromatography
WO2014199201A1 (en) * 2013-06-14 2014-12-18 Agilent Technologies, Inc. Hplc sample introduction with coupling sample reservoirs in parallel between mobile phase drive and separation unit
GB2538103B (en) * 2015-05-08 2021-09-15 Agilent Technologies Inc Correcting sample metering inaccuracy due to thermally induced volume change in sample separation apparatus
US11307181B1 (en) 2018-07-14 2022-04-19 Sielc Technologies Corporation HPLC system with mixed-mode columns for measuring charged analytes in complex mixtures
JP7388206B2 (en) * 2020-01-22 2023-11-29 株式会社島津製作所 Liquid chromatography and analytical methods

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE480943A (en) * 1947-03-04
US2708519A (en) * 1953-01-30 1955-05-17 Ohio Commw Eng Co Chromatographic adsorption apparatus with eluting solvent flow control valve
US2868011A (en) * 1955-12-16 1959-01-13 Gulf Research Development Co Multiple-column chromatographic apparatus
US3097163A (en) * 1958-08-25 1963-07-09 Riddick Thomas Moore Treatment of water in municipal and industrial water systems
GB949108A (en) * 1961-12-06 1964-02-12 Flight Refueling Ltd Improvements in or relating to sampling valves

Also Published As

Publication number Publication date
SE305555B (en) 1968-10-28
US3373872A (en) 1968-03-19
DE1598205B1 (en) 1971-05-19
JPS5247357B1 (en) 1977-12-01

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