GB1027093A - Improvements in chromatography - Google Patents
Improvements in chromatographyInfo
- Publication number
- GB1027093A GB1027093A GB27749/63A GB2774963A GB1027093A GB 1027093 A GB1027093 A GB 1027093A GB 27749/63 A GB27749/63 A GB 27749/63A GB 2774963 A GB2774963 A GB 2774963A GB 1027093 A GB1027093 A GB 1027093A
- Authority
- GB
- United Kingdom
- Prior art keywords
- column
- columns
- mixture
- gas
- valve
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/46—Flow patterns using more than one column
- G01N30/468—Flow patterns using more than one column involving switching between different column configurations
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/40—Flow patterns using back flushing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/44—Flow patterns using recycling of the fraction to be distributed
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/04—Preparation or injection of sample to be analysed
- G01N30/16—Injection
- G01N30/20—Injection using a sampling valve
- G01N2030/202—Injection using a sampling valve rotary valves
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N2030/382—Flow patterns flow switching in a single column
- G01N2030/385—Flow patterns flow switching in a single column by switching valves
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/26—Conditioning of the fluid carrier; Flow patterns
- G01N30/38—Flow patterns
- G01N30/44—Flow patterns using recycling of the fraction to be distributed
- G01N2030/445—Flow patterns using recycling of the fraction to be distributed heart cut
Landscapes
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sustainable Development (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
1, 027, 093. Chromatographic separation of fluid mixtures. PERKIN-ELMER CORPORATION. July 12, 1963 [July 18, 1962], No. 27749/63. Headings B1L and B1X. Mixtures of fluids are separated by chromatography wherein the mixture is passed sequentially and repeatedly through a number of chromatography columns, components, if any, which are ahead of a preselected portion of the mixture are removed and a previously used column is backflushed to remove from this column unwanted components behind the preselected portion and the preselected portion is subsequently passed through the said previously used column. This method may be applied to gas-liquid, gas-solid, liquid-liquid and liquid-solid chromatography and is described in relation to the separation of a middle fraction from a mixture by gas chromatography. In embodiments, two, three or multiples of three columns are used wherein the columns are connected by valves which allow recirculation of the mixture and removal of the unwanted components (Figs. 1 and 3 to 5, not shown). In one embodiment , a fluid mixture, is allowed to pass through two columns with a detector interposed therebetween and wherein the lighter fractions are allowed to leave the front of the second column while the heavier fractions are prevented from entering the second column by altering the connections between the columns immediately after the middle fraction has passed into the second column. The heavier fractions in the first column may then be eluted by backflushing with a purge gas. Simultaneous with the altering of the connections between the first two columns, the second column is joined to a third via a detector and a similar proceedure used regarding the lighter and heavier fractions. The first column is used again for the separation but with the flow in the reverse direction when the connections between the columns are changed again and thereupon column two is purged of heavier fractions. By altering the connections between the three columns, six combinations are obtained and the mixture passed through this cycle of combinations repeatedly. Such an arrangement to produce this effect is shown in Fig. 2, three columns 10, 20 and 30 are connected to a multiport valve 40 which has carrier or purge gas sources P 1 and P 2 , vents V 1 and V 2 and detector 12, and wherein the various positions of the valve governs the combination of the columns and direction of flow of both carrier and eluting gases. In Fig. 6, valve 116 has gas sources P 1 and P 2 at different pressures the higher pressure being used to purge one column quickly while the mixture is passing down the other column prior to linking the columns in series again. The valve governs a two column 80 and 90 arrangement which is mounted on a valve rotor 110 which together with valve 116 allows the combination of and flow directions through the two columns to be altered. The purge or eluting gas may be heated and is not necessarily used at the same pressure as the carrier gas. Two samples may be injected simultaneously into two columns when a six column arrangement is used. If the lighter components of the mixture are sought then these are not vented but passed on to the next column whilst pure carrier gas would be vented or recycled.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US210642A US3220164A (en) | 1962-07-18 | 1962-07-18 | Recirculation chromatography |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1027093A true GB1027093A (en) | 1966-04-20 |
Family
ID=22783681
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB27749/63A Expired GB1027093A (en) | 1962-07-18 | 1963-07-12 | Improvements in chromatography |
Country Status (5)
Country | Link |
---|---|
US (1) | US3220164A (en) |
CH (1) | CH435801A (en) |
DE (1) | DE1498945A1 (en) |
FR (1) | FR1371275A (en) |
GB (1) | GB1027093A (en) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3332218A (en) * | 1964-02-27 | 1967-07-25 | American Air Filter Co | Dust collector apparatus |
GB1189995A (en) * | 1966-08-09 | 1970-04-29 | Bp Chem Int Ltd | Gas Chromatography Apparatus |
US3488921A (en) * | 1968-01-16 | 1970-01-13 | Aquitaine Petrole | Process and apparatus for isotopic enrichment |
US3926589A (en) * | 1973-12-21 | 1975-12-16 | Toe Jokhannesovich Klementi | Device and method for separation of fluid mixture into fractions in a chromatograph |
US3992175A (en) * | 1974-02-11 | 1976-11-16 | Toe Jokhannesovich Klementi | Method of and device for chromatographic separation of fluid mixtures into fractions |
US4066536A (en) * | 1976-08-09 | 1978-01-03 | Micromeritics Instrument Corporation | Particle size separation by suspension flow in an unobstructed passageway |
US4276060A (en) * | 1979-05-22 | 1981-06-30 | The United States Of America As Represented By The United States Department Of Energy | Chromatographic hydrogen isotope separation |
ATE20829T1 (en) * | 1982-04-28 | 1986-08-15 | Duphar Int Res | PRECONCENTRATION COLUMN FOR SUBSTANCES TO BE SEPARATED BY CHROMATOGRAPHY, AND DEVICE FOR A LIQUID CHROMATOGRAPHY SYSTEM AND COUPLING PIECE FOR SUCH DEVICE. |
US5096471A (en) * | 1990-09-28 | 1992-03-17 | The Regents Of The University Of Michigan | Gas chromatography system and methods |
US5281256A (en) * | 1990-09-28 | 1994-01-25 | Regents Of The University Of Michigan | Gas chromatography system with column bifurcation and tunable selectivity |
US5141532A (en) * | 1990-09-28 | 1992-08-25 | The Regents Of The University Of Michigan | Thermal modulation inlet for gas chromatography system |
US5141534A (en) * | 1990-09-28 | 1992-08-25 | The Regents Of The University Of Michigan | Sample collection and inlet systems for gas chromatography apparatus |
US5288310A (en) * | 1992-09-30 | 1994-02-22 | The Regents Of The University Of Michigan | Adsorbent trap for gas chromatography |
US5498279A (en) * | 1994-05-13 | 1996-03-12 | Chromatofast | High speed gas chromatography system for analysis of polar organic compounds |
US6968729B1 (en) * | 2004-02-27 | 2005-11-29 | Uop Llc | Method and apparatus for expediting analysis of samples |
DK2772289T3 (en) * | 2013-03-01 | 2015-08-10 | Chromacon Ag | Chromatographic method for the enrichment and isolation |
CA2851112A1 (en) | 2013-05-06 | 2014-11-06 | Tomas Hudlicky | Methods and apparatus for time-pulsed chromatography |
WO2015094096A1 (en) | 2013-12-19 | 2015-06-25 | Ge Healthcare Bio-Sciences Ab | Rotary valve |
EP3484599B1 (en) * | 2016-07-13 | 2020-04-22 | ChromaCon AG | Purification method and uses thereof |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2841005A (en) * | 1956-12-11 | 1958-07-01 | Gulf Oil Corp | Chromatographic method and apparatus |
DE1079352B (en) * | 1958-03-04 | 1960-04-07 | Perkin Elmer Corp | Device for the separation of substance mixtures by gas chromatography |
US3112639A (en) * | 1960-01-04 | 1963-12-03 | Beckman Instruments Inc | Dual column gas chromatograph and method for analysis |
-
1962
- 1962-07-18 US US210642A patent/US3220164A/en not_active Expired - Lifetime
-
1963
- 1963-07-04 DE DE19631498945 patent/DE1498945A1/en active Pending
- 1963-07-09 CH CH850763A patent/CH435801A/en unknown
- 1963-07-12 GB GB27749/63A patent/GB1027093A/en not_active Expired
- 1963-07-18 FR FR7808A patent/FR1371275A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
DE1498945A1 (en) | 1969-07-03 |
FR1371275A (en) | 1964-09-04 |
CH435801A (en) | 1967-05-15 |
US3220164A (en) | 1965-11-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
GB1027093A (en) | Improvements in chromatography | |
GB1106093A (en) | Chromatography of complex mixtures | |
KR960010366B1 (en) | Method of choromatographic separation | |
US4274967A (en) | Chromatographic apparatus and method | |
Deans | An improved technique for back-flushing gas chromatographic columns | |
GB979373A (en) | Chromatography analysis apparatus and method | |
GB990264A (en) | Valve for gas chromatography apparatus | |
GB949067A (en) | Dual column gas chromatograph and method for analysis | |
GB980348A (en) | Gas chromatographic apparatus | |
GB1183213A (en) | Method and apparatus for Concentration of Ethane and/or Ethylene | |
US2487574A (en) | Chromatographic adsorption | |
US3119251A (en) | Multiple column gas chromatography valve | |
GB1479801A (en) | Liquid phase chromatography analysis | |
GB1236937A (en) | Gas flow switching for chromatographic columns | |
US3524305A (en) | Minimizing switching transients in multiple column chromatography | |
US3884802A (en) | Liquid chromatography injection system | |
US3097519A (en) | favre | |
GB1418503A (en) | Chromatographic apparatus | |
GB1086771A (en) | Apparatus and method for chromatographic analysis | |
GB1355893A (en) | Gas chromatography | |
Ducass et al. | Simple techniques for two-dimensional gas chromatography | |
GB1098265A (en) | Method and apparatus for chromatographic analysis | |
GB1484416A (en) | Chromatographic separation of fluid mixtures into fractions | |
JPS62185164A (en) | Chromatography apparatus | |
JPS62190464A (en) | Gas chromatograph |