GB1090609A - Substituted phenyl-acetonitriles - Google Patents
Substituted phenyl-acetonitrilesInfo
- Publication number
- GB1090609A GB1090609A GB3256866A GB3256866A GB1090609A GB 1090609 A GB1090609 A GB 1090609A GB 3256866 A GB3256866 A GB 3256866A GB 3256866 A GB3256866 A GB 3256866A GB 1090609 A GB1090609 A GB 1090609A
- Authority
- GB
- United Kingdom
- Prior art keywords
- trifluoromethyl
- radical
- isopropyl
- acetonitrile
- reacting
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000007962 benzene acetonitriles Chemical class 0.000 title 1
- -1 alkenyl radical Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- JOIYKSLWXLFGGR-UHFFFAOYSA-N 2-[3-(trifluoromethyl)phenyl]acetonitrile Chemical compound FC(F)(F)C1=CC=CC(CC#N)=C1 JOIYKSLWXLFGGR-UHFFFAOYSA-N 0.000 abstract 2
- WZKSXHQDXQKIQJ-UHFFFAOYSA-N F[C](F)F Chemical compound F[C](F)F WZKSXHQDXQKIQJ-UHFFFAOYSA-N 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- SUSQOBVLVYHIEX-UHFFFAOYSA-N phenylacetonitrile Chemical compound N#CCC1=CC=CC=C1 SUSQOBVLVYHIEX-UHFFFAOYSA-N 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- YHRUOJUYPBUZOS-UHFFFAOYSA-N 1,3-dichloropropane Chemical compound ClCCCCl YHRUOJUYPBUZOS-UHFFFAOYSA-N 0.000 abstract 1
- NAMYKGVDVNBCFQ-UHFFFAOYSA-N 2-bromopropane Chemical compound CC(C)Br NAMYKGVDVNBCFQ-UHFFFAOYSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- MFESCIUQSIBMSM-UHFFFAOYSA-N I-BCP Chemical compound ClCCCBr MFESCIUQSIBMSM-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000029936 alkylation Effects 0.000 abstract 1
- 238000005804 alkylation reaction Methods 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 239000000839 emulsion Substances 0.000 abstract 1
- 244000053095 fungal pathogen Species 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 238000010255 intramuscular injection Methods 0.000 abstract 1
- 239000007927 intramuscular injection Substances 0.000 abstract 1
- 238000010253 intravenous injection Methods 0.000 abstract 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000006187 pill Substances 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/58—Radicals substituted by nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/44—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D317/46—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 ortho- or peri-condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D317/48—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring
- C07D317/50—Methylenedioxybenzenes or hydrogenated methylenedioxybenzenes, unsubstituted on the hetero ring with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to atoms of the carbocyclic ring
- C07D317/60—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Jib Cranes (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEK0056774 | 1965-07-31 | ||
| US55595566A | 1966-06-08 | 1966-06-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1090609A true GB1090609A (en) | 1967-11-08 |
Family
ID=25984100
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3256866A Expired GB1090609A (en) | 1965-07-31 | 1966-07-20 | Substituted phenyl-acetonitriles |
Country Status (11)
| Country | Link |
|---|---|
| BE (1) | BE684868A (xx) |
| BR (1) | BR6681685D0 (xx) |
| CH (1) | CH497389A (xx) |
| DE (1) | DE1493904A1 (xx) |
| DK (1) | DK120241B (xx) |
| FI (1) | FI45187C (xx) |
| FR (3) | FR313F (xx) |
| GB (1) | GB1090609A (xx) |
| NL (1) | NL146797B (xx) |
| NO (1) | NO118111B (xx) |
| SE (1) | SE352886B (xx) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4940780A (en) * | 1986-12-11 | 1990-07-10 | Basf Aktiengesellschaft | Basically substituted phenylacetonitriles, their preparation and drugs containing these compounds |
| EP2170050A1 (en) * | 2007-06-20 | 2010-04-07 | Milestone Pharmaceuticals Inc. | Short acting phenylalkylamine calcium channel blockers and uses thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3468863D1 (en) * | 1984-06-15 | 1988-02-25 | Heumann Ludwig & Co Gmbh | Method for the preparation of phenylacetonitrile substituted by a basic radical |
-
1965
- 1965-07-31 DE DE19651493904 patent/DE1493904A1/de not_active Withdrawn
-
1966
- 1966-07-20 GB GB3256866A patent/GB1090609A/en not_active Expired
- 1966-07-26 CH CH1079566A patent/CH497389A/de not_active IP Right Cessation
- 1966-07-29 DK DK395466A patent/DK120241B/da unknown
- 1966-07-29 BR BR18168566A patent/BR6681685D0/pt unknown
- 1966-07-29 FR FR313D patent/FR313F/fr not_active Expired
- 1966-07-29 BE BE684868D patent/BE684868A/xx unknown
- 1966-07-29 FI FI201866A patent/FI45187C/fi active
- 1966-07-29 SE SE1037466A patent/SE352886B/xx unknown
- 1966-07-29 NL NL666610730A patent/NL146797B/xx unknown
- 1966-07-29 NO NO16410666A patent/NO118111B/no unknown
-
1967
- 1967-06-08 FR FR1553708D patent/FR1553708A/fr not_active Expired
- 1967-09-08 FR FR120463A patent/FR7508M/fr not_active Expired
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4940780A (en) * | 1986-12-11 | 1990-07-10 | Basf Aktiengesellschaft | Basically substituted phenylacetonitriles, their preparation and drugs containing these compounds |
| EP2170050A1 (en) * | 2007-06-20 | 2010-04-07 | Milestone Pharmaceuticals Inc. | Short acting phenylalkylamine calcium channel blockers and uses thereof |
| EP2170050A4 (en) * | 2007-06-20 | 2010-11-24 | Milestone Pharmaceuticals Inc | AGENTS BLOCKING CALCIUM CHANNELS BASED ON PHENYLALKYLAMINE BRIEF TIME OF ACTION AND USES THEREOF |
| AU2008266798B2 (en) * | 2007-06-20 | 2014-07-17 | Milestone Pharmaceuticals Inc. | Short acting phenylalkylamine calcium channel blockers and uses thereof |
| US9227918B2 (en) | 2007-06-20 | 2016-01-05 | Milestone Pharmaceuticals | Short acting phenylalkylamine calcium channel blockers and uses thereof |
| US9463179B2 (en) | 2007-06-20 | 2016-10-11 | Milestone Pharmaceuticals Inc. | Short acting phenylalkylamine calcium channel blockers and uses thereof |
| US9737503B2 (en) | 2007-06-20 | 2017-08-22 | Milestone Pharmaceuticals Inc. | Short acting phenylalkylamine calcium channel blockers and uses thereof |
| US10010522B2 (en) | 2007-06-20 | 2018-07-03 | Milestone Pharmaceuticals Inc. | Short acting phenylalkylamine calcium channel blockers and uses thereof |
| US10010524B2 (en) | 2007-06-20 | 2018-07-03 | Milestone Pharmaceuticals Inc. | Short acting phenylalkylamine calcium channel blockers and uses thereof |
| US10010523B2 (en) | 2007-06-20 | 2018-07-03 | Milestone Pharmaceuticals Inc. | Short acting phenylalkylamine calcium channel blockers and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| DK120241B (da) | 1971-05-03 |
| FI45187B (xx) | 1971-12-31 |
| NL6610730A (xx) | 1967-02-01 |
| NL146797B (nl) | 1975-08-15 |
| FI45187C (fi) | 1972-04-10 |
| SE352886B (xx) | 1973-01-15 |
| BE684868A (xx) | 1967-01-30 |
| DE1493904A1 (de) | 1969-06-19 |
| BR6681685D0 (pt) | 1973-10-25 |
| CH497389A (de) | 1970-10-15 |
| NO118111B (xx) | 1969-11-10 |
| DE1593921A1 (de) | 1970-10-01 |
| FR1553708A (xx) | 1969-01-17 |
| DE1593921B2 (de) | 1976-01-15 |
| FR7508M (xx) | 1969-12-15 |
| FR313F (xx) | 1970-05-20 |
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