GB1081667A - Method of preparing solid stable preparations of sensitive active substances - Google Patents
Method of preparing solid stable preparations of sensitive active substancesInfo
- Publication number
- GB1081667A GB1081667A GB17091/66A GB1709166A GB1081667A GB 1081667 A GB1081667 A GB 1081667A GB 17091/66 A GB17091/66 A GB 17091/66A GB 1709166 A GB1709166 A GB 1709166A GB 1081667 A GB1081667 A GB 1081667A
- Authority
- GB
- United Kingdom
- Prior art keywords
- preparations
- methyl
- active substance
- active substances
- cellulose derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000013543 active substance Substances 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 3
- 239000007787 solid Substances 0.000 title abstract 3
- 238000000034 method Methods 0.000 title 1
- 239000001913 cellulose Substances 0.000 abstract 3
- 229920002678 cellulose Polymers 0.000 abstract 3
- -1 stable Substances 0.000 abstract 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 abstract 2
- 239000003125 aqueous solvent Substances 0.000 abstract 2
- 229940088594 vitamin Drugs 0.000 abstract 2
- 229930003231 vitamin Natural products 0.000 abstract 2
- 235000013343 vitamin Nutrition 0.000 abstract 2
- 239000011782 vitamin Substances 0.000 abstract 2
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 abstract 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 abstract 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 239000004411 aluminium Substances 0.000 abstract 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052782 aluminium Inorganic materials 0.000 abstract 1
- 235000012211 aluminium silicate Nutrition 0.000 abstract 1
- 239000003963 antioxidant agent Substances 0.000 abstract 1
- 229910052791 calcium Inorganic materials 0.000 abstract 1
- 239000011575 calcium Substances 0.000 abstract 1
- 229910000019 calcium carbonate Inorganic materials 0.000 abstract 1
- 235000010216 calcium carbonate Nutrition 0.000 abstract 1
- 235000012241 calcium silicate Nutrition 0.000 abstract 1
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 abstract 1
- 229960005091 chloramphenicol Drugs 0.000 abstract 1
- 239000006185 dispersion Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 229960002568 ethinylestradiol Drugs 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 1
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 1
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 1
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 1
- 239000000391 magnesium silicate Substances 0.000 abstract 1
- 235000012243 magnesium silicates Nutrition 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 abstract 1
- 235000012239 silicon dioxide Nutrition 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 150000003722 vitamin derivatives Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P10/00—Shaping or working of foodstuffs characterised by the products
- A23P10/30—Encapsulation of particles, e.g. foodstuff additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
- A23P20/00—Coating of foodstuffs; Coatings therefor; Making laminated, multi-layered, stuffed or hollow foodstuffs
- A23P20/10—Coating with edible coatings, e.g. with oils or fats
- A23P20/105—Coating with compositions containing vegetable or microbial fermentation gums, e.g. cellulose or derivatives; Coating with edible polymers, e.g. polyvinyalcohol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/143—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Polymers & Plastics (AREA)
- Food Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Animal Husbandry (AREA)
- Inorganic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEM0065285 | 1965-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1081667A true GB1081667A (en) | 1967-08-31 |
Family
ID=7311393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB17091/66A Expired GB1081667A (en) | 1965-05-18 | 1966-04-09 | Method of preparing solid stable preparations of sensitive active substances |
Country Status (10)
| Country | Link |
|---|---|
| BE (1) | BE681216A (he) |
| BR (1) | BR6679597D0 (he) |
| CH (1) | CH483201A (he) |
| DE (1) | DE1492034A1 (he) |
| DK (1) | DK113235B (he) |
| ES (1) | ES326829A1 (he) |
| FR (1) | FR1522233A (he) |
| GB (1) | GB1081667A (he) |
| IL (1) | IL25710A (he) |
| NL (1) | NL6605645A (he) |
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2218085A1 (he) * | 1973-02-16 | 1974-09-13 | Hoffmann La Roche | |
| FR2218086A1 (he) * | 1973-02-21 | 1974-09-13 | Schering Ag | |
| EP0002574A1 (en) * | 1977-12-08 | 1979-06-27 | Beecham Group Plc | Dispersions in particulate form, a process for making the dispersions and pharmaceutical compositions containing them |
| US4212863A (en) | 1977-10-29 | 1980-07-15 | Akzo N.V. | Highly concentrated pharmaceutical formulations of steroids and processes for their preparation |
| US4406879A (en) | 1979-11-07 | 1983-09-27 | Nippon Kayaku Kabushiki Kaisha | Phthalazinol preparation |
| EP0116755A1 (en) * | 1983-02-22 | 1984-08-29 | Teijin Limited | Composition for solid pharmaceutical preparations of active vitamins D3 and process for preparation thereof |
| EP0240773A1 (en) * | 1986-04-02 | 1987-10-14 | Fujisawa Pharmaceutical Co., Ltd. | Solid dispersion composition of FR-900506 substance |
| US5158944A (en) * | 1989-03-01 | 1992-10-27 | Teijin Limited | Solid pharmaceutical preparations of active form of vitamin d3 of improved stability |
| WO2003092406A1 (en) * | 2002-05-02 | 2003-11-13 | Volker Kuellmer | Coated, agglomerated phytochemicals |
| WO2007068287A1 (en) * | 2005-12-15 | 2007-06-21 | Laboratoria Qualiphar | Sustained release vitamin preparation |
| US7368138B2 (en) | 2002-03-21 | 2008-05-06 | Archer-Daniels-Midland Company | Extraction of phytosterols from corn fiber using green solvents |
| EP1997480A1 (en) * | 2007-06-01 | 2008-12-03 | The Jordanian Pharmaceutical Manufacturing Co. | Mineral-fiber solid dispersion, method for preparing the same and use thereof as pharmaceutical tableting aid |
| US8563066B2 (en) | 2007-12-17 | 2013-10-22 | New World Pharmaceuticals, Llc | Sustained release of nutrients in vivo |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BE791458A (fr) * | 1972-07-31 | 1973-05-16 | Merck & Co Inc | Produit microencapsule |
| DE2845326C2 (de) * | 1978-10-18 | 1985-05-23 | Beiersdorf Ag, 2000 Hamburg | Verwendung einer spezifischen mikrodispersen, amorphen, porösen Kieselsäure zur Herstellung von Digoxin enthaltenden Tabletten mit stark beschleunigter Wirkstoff-Freisetzung |
| EP0315964B1 (en) * | 1987-11-11 | 1993-01-07 | Laboratoires Pharmascience | A novel pharmaceutical composition comprising exifone and water-soluble polymer |
| FR2741533B1 (fr) * | 1995-11-28 | 1998-02-06 | Grinda Jean Robert | Procede de stabilisation des acides gras polyinsatures et utilisation de ces produits stabilises en cosmetologie |
| CA2713765A1 (en) * | 2008-02-06 | 2009-08-13 | Innov'ia | Pulverulent composition and a process for preparing the same |
-
1965
- 1965-05-18 DE DE19651492034 patent/DE1492034A1/de active Pending
-
1966
- 1966-03-17 CH CH385766A patent/CH483201A/de not_active IP Right Cessation
- 1966-04-09 GB GB17091/66A patent/GB1081667A/en not_active Expired
- 1966-04-27 NL NL6605645A patent/NL6605645A/xx unknown
- 1966-05-04 IL IL25710A patent/IL25710A/he unknown
- 1966-05-16 FR FR61683A patent/FR1522233A/fr not_active Expired
- 1966-05-16 DK DK249666AA patent/DK113235B/da unknown
- 1966-05-17 ES ES0326829A patent/ES326829A1/es not_active Expired
- 1966-05-18 BE BE681216D patent/BE681216A/xx unknown
- 1966-05-18 BR BR179597/66A patent/BR6679597D0/pt unknown
Cited By (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2218085A1 (he) * | 1973-02-16 | 1974-09-13 | Hoffmann La Roche | |
| FR2218086A1 (he) * | 1973-02-21 | 1974-09-13 | Schering Ag | |
| US4212863A (en) | 1977-10-29 | 1980-07-15 | Akzo N.V. | Highly concentrated pharmaceutical formulations of steroids and processes for their preparation |
| EP0002574A1 (en) * | 1977-12-08 | 1979-06-27 | Beecham Group Plc | Dispersions in particulate form, a process for making the dispersions and pharmaceutical compositions containing them |
| US4406879A (en) | 1979-11-07 | 1983-09-27 | Nippon Kayaku Kabushiki Kaisha | Phthalazinol preparation |
| EP0116755A1 (en) * | 1983-02-22 | 1984-08-29 | Teijin Limited | Composition for solid pharmaceutical preparations of active vitamins D3 and process for preparation thereof |
| US4729895A (en) * | 1983-02-22 | 1988-03-08 | Teijin Limited | Composition for solid pharmaceutical preparations of active vitamins D.sub.3 |
| EP0240773A1 (en) * | 1986-04-02 | 1987-10-14 | Fujisawa Pharmaceutical Co., Ltd. | Solid dispersion composition of FR-900506 substance |
| US5158944A (en) * | 1989-03-01 | 1992-10-27 | Teijin Limited | Solid pharmaceutical preparations of active form of vitamin d3 of improved stability |
| US7368138B2 (en) | 2002-03-21 | 2008-05-06 | Archer-Daniels-Midland Company | Extraction of phytosterols from corn fiber using green solvents |
| US8114447B2 (en) | 2002-03-21 | 2012-02-14 | Archer Daniels Midland Company | Extraction of phytosterols from corn fiber using green solvents |
| WO2003092406A1 (en) * | 2002-05-02 | 2003-11-13 | Volker Kuellmer | Coated, agglomerated phytochemicals |
| WO2007068287A1 (en) * | 2005-12-15 | 2007-06-21 | Laboratoria Qualiphar | Sustained release vitamin preparation |
| EP1997480A1 (en) * | 2007-06-01 | 2008-12-03 | The Jordanian Pharmaceutical Manufacturing Co. | Mineral-fiber solid dispersion, method for preparing the same and use thereof as pharmaceutical tableting aid |
| WO2008145361A1 (en) * | 2007-06-01 | 2008-12-04 | The Jordanian Pharmaceutical Manufacturing Co. | Mineral-fiber solid dispersion, method for preparing the same, and use thereof as pharmaceutical tableting aid |
| US8563066B2 (en) | 2007-12-17 | 2013-10-22 | New World Pharmaceuticals, Llc | Sustained release of nutrients in vivo |
| US9538775B2 (en) | 2007-12-17 | 2017-01-10 | New World Pharmaceuticals, Llc | Sustained release of nutrients in vivo |
| US9554586B2 (en) | 2007-12-17 | 2017-01-31 | New World Pharmaceuticals, Llc | Sustained release of nutrients in vivo |
Also Published As
| Publication number | Publication date |
|---|---|
| ES326829A1 (es) | 1967-07-01 |
| FR1522233A (fr) | 1968-04-26 |
| DK113235B (da) | 1969-03-03 |
| BE681216A (he) | 1966-11-18 |
| DE1492034A1 (de) | 1969-02-20 |
| IL25710A (he) | 1970-02-19 |
| CH483201A (de) | 1969-12-31 |
| BR6679597D0 (pt) | 1973-10-23 |
| NL6605645A (he) | 1966-11-21 |
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