GB1002211A - Method of preparing sustained release pharmaceutical tablets - Google Patents

Method of preparing sustained release pharmaceutical tablets

Info

Publication number
GB1002211A
GB1002211A GB23432/63A GB2343263A GB1002211A GB 1002211 A GB1002211 A GB 1002211A GB 23432/63 A GB23432/63 A GB 23432/63A GB 2343263 A GB2343263 A GB 2343263A GB 1002211 A GB1002211 A GB 1002211A
Authority
GB
United Kingdom
Prior art keywords
water
solvent
insoluble
solution
lattice
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB23432/63A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of GB1002211A publication Critical patent/GB1002211A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Medicinal Preparation (AREA)

Abstract

Sustained-release tablets are prepared by dissolving a medicament in a solvent to form a solution, mixing the solution with a water-insoluble lattice-forming material which is insoluble in the solvent, removing said solvent to obtain a substantially dry mixture and compressing said mixture into tablets which thereby have the medicament uniformly dispersed in the lattice structure formed by the water-insoluble material. The lattice-forming material may be aluminium oxide, a water-insoluble metal salt of a fatty acid containing from 6-22 C. atoms e.g. calcium stearate, bentonite, silica gel, barium sulphate, or mixtures thereof. The solvent may be water, a C1-6 alcohol or a mixture thereof. Water-soluble forms of a wide range of drugs may be used e.g. antibiotics, steroids and vitamins. Optional ingredients are (a) inert, water-soluble carriers e.g. urea, glycine, glycol, polyvinyl pyrrolidone, polyvinyl alcohol or mixtures thereof; (b) water-resistant agents e.g. methyl cellulose, fatty acids, fatty alcohols, fatty esters, fatty oils and wax, which slow down the release of the drug; (c) surface-active agents e.g. sodium lauryl sulphate, polysorbates and bis-2-ethylhexyl sodium sulpho-succinate; (d) anti-acid or intestinal fluid solubilising agents e.g. cellulose acetate phthalate, starch acetate phthalate, polyvinyl acetate phthalate or mixtures thereof. The optional ingredients and drug are put into solution and mixed uniformly with the water-insoluble particles. Alternatively, the particles may be sprayed with the said solution of drug and modifiers. In a modification, a non-reactive water-soluble carrier is dissolved in a solvent, the solution is mixed with the water-insoluble lattice-forming material, the solvent is removed, an enzyme is mixed with the dry mixture and the resultant product is compressed into tablets.
GB23432/63A 1962-06-12 1963-06-12 Method of preparing sustained release pharmaceutical tablets Expired GB1002211A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201822A US3148124A (en) 1962-06-12 1962-06-12 Method of preparing sustained release pharmaceutical tablets

Publications (1)

Publication Number Publication Date
GB1002211A true GB1002211A (en) 1965-08-25

Family

ID=22747445

Family Applications (1)

Application Number Title Priority Date Filing Date
GB23432/63A Expired GB1002211A (en) 1962-06-12 1963-06-12 Method of preparing sustained release pharmaceutical tablets

Country Status (3)

Country Link
US (1) US3148124A (en)
DE (1) DE1467906A1 (en)
GB (1) GB1002211A (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2359607A1 (en) * 1976-07-27 1978-02-24 Sandoz Sa NEW PHARMACEUTICAL COMPOSITION ALLOWING A CONTROLLED RELEASE OF THE ACTIVE SUBSTANCE
FR2405066A1 (en) * 1977-05-25 1979-05-04 Commw Scient Ind Res Org RELEASE COMPOSITIONS FOR THE ADMINISTRATION OF THERAPEUTIC AGENTS TO RUMINANTS
US4673527A (en) * 1985-05-20 1987-06-16 Autotrol Corporation Tablet granulation

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1467781A1 (en) * 1963-07-15 1968-12-05 Boehringer Sohn Ingelheim Process for the production of coated tablets with extended release of active ingredients
US3350270A (en) * 1964-09-18 1967-10-31 Leeds Dixon Lab Inc Aluminum aspirin film-enveloped therapeutic agents in sustained release dosage form
US3400197A (en) * 1965-01-26 1968-09-03 Robins Co Inc A H Compressible sustained release pharmaceutical tablet lipid-colloidal silica gel matrix fragment granules
GB1359643A (en) * 1970-09-28 1974-07-10 Controlled Medications Controlled release medicament
US3909444A (en) * 1971-08-05 1975-09-30 Ncr Co Microcapsule
FR2183546B1 (en) * 1972-05-10 1975-06-20 Servier Lab
US3957966A (en) * 1972-05-19 1976-05-18 Gaf Corporation Stabilized vitamin food coatings
US3923969A (en) * 1973-06-12 1975-12-02 Battelle Institut E V Carrier system for a drug with sustained release
US4013785A (en) * 1975-03-21 1977-03-22 Bristol-Myers Company Apap tablet containing fumed silica and process for manufacturing same
US4291016A (en) * 1976-07-27 1981-09-22 Sandoz Ltd. Enteric coated mixture of 4-(2-hydroxy-3-isopropylamino-propoxy) indole and sodium lauryl sulphate
HU174057B (en) * 1976-09-17 1979-10-28 Richter Gedeon Vegyeszet Coating material for the regulated release of the active substance in biologically active preparations and process for preparing such preparations with regulated release of the active substance
DE2845326C2 (en) * 1978-10-18 1985-05-23 Beiersdorf Ag, 2000 Hamburg Use of a specific microdisperse, amorphous, porous silica for the production of digoxin-containing tablets with a strongly accelerated release of active ingredient
FI63335B (en) * 1979-02-02 1983-02-28 Orion Yhtymae Oy FARING REFERENCE FOR A TABLETTER WITH A LIGHT LIGHT OF AN EFFECTIVE
JPS55153715A (en) * 1979-05-18 1980-11-29 Nikken Kagaku Kk Prolonged granule of theophylline
US4264573A (en) * 1979-05-21 1981-04-28 Rowell Laboratories, Inc. Pharmaceutical formulation for slow release via controlled surface erosion
US4547358A (en) * 1980-05-06 1985-10-15 Mead Johnson & Company Sustained release tablet containing at least 95 percent theophylline
JPS6056122B2 (en) * 1980-05-21 1985-12-09 塩野義製薬株式会社 sustained release formulation
US4465660A (en) * 1981-04-01 1984-08-14 Mead Johnson & Company Sustained release tablet containing at least 95 percent theophylline
GB2186485B (en) * 1986-02-13 1988-09-07 Ethical Pharma Ltd Slow release formulation
DE3827214A1 (en) * 1988-08-11 1990-02-15 Roehm Gmbh RETARDED MEDICAMENT AND METHOD FOR THE PRODUCTION THEREOF
AU7881000A (en) * 1999-08-16 2001-03-13 Henceforth Hibernia, Inc. Therapeutic and prophylactic compositions including catalytic biomimetic solids and methods to prepare and use them
TWI355276B (en) * 2003-01-14 2012-01-01 Akira Tsuji Gastrointestinal absorption enhancer mediated by p
WO2005027843A2 (en) * 2003-09-19 2005-03-31 Penwest Pharmaceuticals Co. Chronotherapeutic dosage forms

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2918411A (en) * 1957-11-01 1959-12-22 Olin Mathieson Pharmaceutical preparations
US2957804A (en) * 1958-06-06 1960-10-25 Harlan R Shuyler Pesticide
US3102845A (en) * 1960-11-18 1963-09-03 Mcneilab Inc Pharmaceutical tablet

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2359607A1 (en) * 1976-07-27 1978-02-24 Sandoz Sa NEW PHARMACEUTICAL COMPOSITION ALLOWING A CONTROLLED RELEASE OF THE ACTIVE SUBSTANCE
FR2405066A1 (en) * 1977-05-25 1979-05-04 Commw Scient Ind Res Org RELEASE COMPOSITIONS FOR THE ADMINISTRATION OF THERAPEUTIC AGENTS TO RUMINANTS
US4673527A (en) * 1985-05-20 1987-06-16 Autotrol Corporation Tablet granulation

Also Published As

Publication number Publication date
DE1467906A1 (en) 1969-01-16
US3148124A (en) 1964-09-08

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