GB1054092A - - Google Patents
Info
- Publication number
- GB1054092A GB1054092A GB1054092DA GB1054092A GB 1054092 A GB1054092 A GB 1054092A GB 1054092D A GB1054092D A GB 1054092DA GB 1054092 A GB1054092 A GB 1054092A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- alkyl
- methyl
- bicyclooctane
- acetyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Filtering Of Dispersed Particles In Gases (AREA)
Abstract
1,054,092. Bicyclo [2.2.2]-octanes. E. I. DU PONT DE NEMOURS & CO. April 23, 1964 [May 1, 1963], No. 16927/64. Heading C2C. [Also in Division C5] New compounds are of general formula where R is hydrogen or alkyl (1-6 C); R 1 is -N=CH-Ph, polymethyleneimine (4-6 C), or -NR 2 R 3 , R 2 being hydrogen or alkyl (1-6 C) optionally substituted by hydroxy, alkoxy (1-2 C), NH 2 , NHalkyl or N(alkyl) 2 (said alkyl having 1-4 C), and R 3 having one of the meanings of R 2 or being Cl, Br, CHO, CH 2 COOH, CH 2 COOCH 3 or CH 2 COOC 2 H 5 ; and salts of the basic compounds; and N-oxides of compounds where R 1 is dialkylamino or polymethyleneimino. Various methods of preparation are described. The 1-aminobicyclooctane is prepared by ammoniation of the 1,4-diiodo compound, and with the 4-alkyl compounds is also prepared from corresponding bicyclooctane carboxylic acids by the Schmidt technique. The other compounds are all obtained from these with appropriate reagents; or from bicyclooctanes having in the 1-position an N-acetyl or cyclic lactam group by hydrolysis or reduction; or by replacing a 1-bromo atom by formamido. Starting materials obtained in examples are: 1,2,3,4 - tetrachlorobicyclooct - 2 - ene, 1,4- dichlorobicyclooctane and the 1,4-dihydroxy and 1,4-diiodo compounds; 1-methyl-4-carboxy - bicyclooctane; 1 - methyl - bicyclooctan- 4-ol-2-one (and its hydrazone) and 1-methyl-4 hydroxy- and -acetamido-bicyclooctane; 1-(N- methyl, N-acetyl, N-butyryl and N-3-methoxypropionyl - aminobicyclooctanes ; N-bicyclooctyl-pyrrolidin-2-one. Pharmaceutical compositions (e.g. tablets, capsules, solutions) comprise the new antiviral compounds with carriers, and they may also be incorporated into animal feeds and concentrates therefor.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27714163A | 1963-05-01 | 1963-05-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1054092A true GB1054092A (en) |
Family
ID=23059561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1054092D Active GB1054092A (en) | 1963-05-01 |
Country Status (15)
| Country | Link |
|---|---|
| AT (6) | AT289058B (en) |
| BE (1) | BE646690A (en) |
| BR (1) | BR6458641D0 (en) |
| CH (1) | CH461470A (en) |
| DE (1) | DE1468759B2 (en) |
| DK (3) | DK121370B (en) |
| ES (1) | ES299408A1 (en) |
| FI (3) | FI43311B (en) |
| FR (1) | FR1472022A (en) |
| GB (1) | GB1054092A (en) |
| LU (1) | LU45912A1 (en) |
| MY (1) | MY6800045A (en) |
| NL (1) | NL6404759A (en) |
| NO (1) | NO116718B (en) |
| SE (4) | SE307573B (en) |
-
0
- GB GB1054092D patent/GB1054092A/en active Active
-
1964
- 1964-04-17 BE BE646690D patent/BE646690A/xx unknown
- 1964-04-20 LU LU45912D patent/LU45912A1/xx unknown
- 1964-04-21 DE DE19641468759 patent/DE1468759B2/en active Granted
- 1964-04-22 CH CH523764A patent/CH461470A/en unknown
- 1964-04-22 AT AT853269A patent/AT289058B/en not_active IP Right Cessation
- 1964-04-22 AT AT10125/67A patent/AT285568B/en not_active IP Right Cessation
- 1964-04-22 AT AT10126/67A patent/AT285569B/en not_active IP Right Cessation
- 1964-04-22 AT AT853169A patent/AT289057B/en not_active IP Right Cessation
- 1964-04-22 AT AT10124/67A patent/AT279578B/en active
- 1964-04-22 AT AT354564A patent/AT269104B/en active
- 1964-04-23 FI FI0862/64A patent/FI43311B/fi active
- 1964-04-23 BR BR158641/64A patent/BR6458641D0/en unknown
- 1964-04-29 NL NL6404759A patent/NL6404759A/xx unknown
- 1964-04-29 SE SE5361/64A patent/SE307573B/xx unknown
- 1964-04-29 DK DK215264AA patent/DK121370B/en unknown
- 1964-04-29 SE SE01716/67A patent/SE330691B/xx unknown
- 1964-04-30 ES ES299408A patent/ES299408A1/en not_active Expired
- 1964-04-30 FR FR973032A patent/FR1472022A/en not_active Expired
-
1965
- 1965-07-09 DK DK353065AA patent/DK114198B/en unknown
- 1965-07-09 DK DK352965AA patent/DK120078B/en unknown
-
1966
- 1966-01-24 NO NO16138366A patent/NO116718B/no unknown
-
1967
- 1967-02-07 SE SE01718/67A patent/SE325877B/xx unknown
- 1967-02-07 SE SE01717/67A patent/SE325876B/xx unknown
-
1968
- 1968-12-31 MY MY196845A patent/MY6800045A/en unknown
-
1969
- 1969-07-30 FI FI2265/69A patent/FI42716B/fi active
- 1969-07-30 FI FI2266/69A patent/FI42717B/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| BR6458641D0 (en) | 1973-09-11 |
| AT289058B (en) | 1971-04-13 |
| ES299408A1 (en) | 1964-07-01 |
| AT285569B (en) | 1970-11-10 |
| AT279578B (en) | 1970-03-10 |
| CH461470A (en) | 1968-08-31 |
| FI43311B (en) | 1970-11-30 |
| SE325877B (en) | 1970-07-13 |
| AT289057B (en) | 1971-04-13 |
| AT285568B (en) | 1970-11-10 |
| DE1468759B2 (en) | 1973-07-26 |
| FI42716B (en) | 1970-06-30 |
| AT269104B (en) | 1969-03-10 |
| DE1468759A1 (en) | 1969-07-03 |
| MY6800045A (en) | 1968-12-31 |
| FI42717B (en) | 1970-06-30 |
| SE325876B (en) | 1970-07-13 |
| DK121370B (en) | 1971-10-11 |
| SE330691B (en) | 1970-11-30 |
| NL6404759A (en) | 1964-11-02 |
| NO116718B (en) | 1969-05-12 |
| DK120078B (en) | 1971-04-05 |
| FR1472022A (en) | 1967-03-10 |
| DK114198B (en) | 1969-06-09 |
| LU45912A1 (en) | 1964-06-20 |
| BE646690A (en) | 1964-08-17 |
| SE307573B (en) | 1969-01-13 |
| DE1468759C3 (en) | 1974-03-07 |
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