ES299408A1 - Procedure for the preparation of an anti-virus-provided composite (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for the preparation of an anti-virus-provided composite (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES299408A1
ES299408A1 ES299408A ES299408A ES299408A1 ES 299408 A1 ES299408 A1 ES 299408A1 ES 299408 A ES299408 A ES 299408A ES 299408 A ES299408 A ES 299408A ES 299408 A1 ES299408 A1 ES 299408A1
Authority
ES
Spain
Prior art keywords
compound
alkyl
carbon atoms
reaction
halide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES299408A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EIDP Inc
Original Assignee
EI Du Pont de Nemours and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by EI Du Pont de Nemours and Co filed Critical EI Du Pont de Nemours and Co
Publication of ES299408A1 publication Critical patent/ES299408A1/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C07D295/033Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Filtering Of Dispersed Particles In Gases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Method of preparing a compound endowed with anti-virus properties, of the formula: ** (See formula) ** where R is hydrogen or alkyl of 1 to 6 carbon atoms; R1 is (see formula), where n is from 4 to 6; -NR2R3; -NR2R3H + X-, wherein R2 hydrogen, alkyl of 1 to 6 carbon atoms, and substituted alkyl where the alkyl has 1 to 6 carbon atoms and the substitute is hydroxyl, alkoxy of 1 to 2 carbon atoms, -NH2 , -NHR4, -NR4R5, where R2 is chloro, bromo, formyl, -CH2 -COOH, -CH2-COOCH3 or -CH2-COOC2H5, R4 and R5 are each alkyl of 1 to 4 carbon atoms and X- it is a non-toxic anion; salts of said compound and hydrolyzable compounds in said compound. ** (See formula) ** where R6 and R7 are each alkyl of 1 to 6 carbon atoms, and where R6 and R7 can be joined together to form the group - (CH2) n- where n is a positive integer from 4 to 6, which process comprises -a) the ammoniation of 1,4-diiodobicyclo (2,2,2) octane or b) the attachment of a corresponding 4-alkylbicyclo [2,2,2] octane carboxylic acid or derivative thereof to the reaction of Hoffmann, Curtius or Schmidt; c) the acylation of a compound in which R1 is NH2 or NHR2 with a suitable acylating agent and the subjection of the acylamide optionally to reduction, or d) the reaction of a compound in which R1 is NH2 or NHR2 with a suitable alkylene oxide , haloalkane carboxylic acid or derivative thereof, alkyl halide, aminoalkyl halide, hydroxyalkyl halide or alkoxyalkyl halide, or e) the attachment of a corresponding 1-ol or 1-ene to the Ritter reaction, of) the reaction of a compound in which R1 is NHR2 or MR2R3 and wherein R2 and/or R3 contain an OH group with a halogenating agent and the subsequent substitution of the halogen atom for NH2, NHR4 or NR4R5 or g) the reaction of a compound in the that R1 is NH2 with benzaldehyde oh) the reaction of a compound wherein R1 is NR6R7 with an oxidation agent. (Machine-translation by Google Translate, not legally binding)
ES299408A 1963-05-01 1964-04-30 Procedure for the preparation of an anti-virus-provided composite (Machine-translation by Google Translate, not legally binding) Expired ES299408A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US27714163A 1963-05-01 1963-05-01

Publications (1)

Publication Number Publication Date
ES299408A1 true ES299408A1 (en) 1964-07-01

Family

ID=23059561

Family Applications (1)

Application Number Title Priority Date Filing Date
ES299408A Expired ES299408A1 (en) 1963-05-01 1964-04-30 Procedure for the preparation of an anti-virus-provided composite (Machine-translation by Google Translate, not legally binding)

Country Status (15)

Country Link
AT (6) AT279578B (en)
BE (1) BE646690A (en)
BR (1) BR6458641D0 (en)
CH (1) CH461470A (en)
DE (1) DE1468759B2 (en)
DK (3) DK121370B (en)
ES (1) ES299408A1 (en)
FI (3) FI43311B (en)
FR (1) FR1472022A (en)
GB (1) GB1054092A (en)
LU (1) LU45912A1 (en)
MY (1) MY6800045A (en)
NL (1) NL6404759A (en)
NO (1) NO116718B (en)
SE (4) SE330691B (en)

Also Published As

Publication number Publication date
DE1468759C3 (en) 1974-03-07
FI42716B (en) 1970-06-30
BE646690A (en) 1964-08-17
FI42717B (en) 1970-06-30
NO116718B (en) 1969-05-12
AT285569B (en) 1970-11-10
BR6458641D0 (en) 1973-09-11
FI43311B (en) 1970-11-30
DK121370B (en) 1971-10-11
DK114198B (en) 1969-06-09
DE1468759A1 (en) 1969-07-03
SE325877B (en) 1970-07-13
AT285568B (en) 1970-11-10
AT269104B (en) 1969-03-10
SE330691B (en) 1970-11-30
AT289058B (en) 1971-04-13
CH461470A (en) 1968-08-31
AT289057B (en) 1971-04-13
SE307573B (en) 1969-01-13
NL6404759A (en) 1964-11-02
DK120078B (en) 1971-04-05
SE325876B (en) 1970-07-13
LU45912A1 (en) 1964-06-20
AT279578B (en) 1970-03-10
FR1472022A (en) 1967-03-10
MY6800045A (en) 1968-12-31
DE1468759B2 (en) 1973-07-26
GB1054092A (en)

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