ES299408A1 - Procedure for the preparation of an anti-virus-provided composite (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of an anti-virus-provided composite (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES299408A1 ES299408A1 ES299408A ES299408A ES299408A1 ES 299408 A1 ES299408 A1 ES 299408A1 ES 299408 A ES299408 A ES 299408A ES 299408 A ES299408 A ES 299408A ES 299408 A1 ES299408 A1 ES 299408A1
- Authority
- ES
- Spain
- Prior art keywords
- compound
- alkyl
- carbon atoms
- reaction
- halide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
- C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
- C07D295/033—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring with the ring nitrogen atoms directly attached to carbocyclic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Filtering Of Dispersed Particles In Gases (AREA)
Abstract
Method of preparing a compound endowed with anti-virus properties, of the formula: ** (See formula) ** where R is hydrogen or alkyl of 1 to 6 carbon atoms; R1 is (see formula), where n is from 4 to 6; -NR2R3; -NR2R3H + X-, wherein R2 hydrogen, alkyl of 1 to 6 carbon atoms, and substituted alkyl where the alkyl has 1 to 6 carbon atoms and the substitute is hydroxyl, alkoxy of 1 to 2 carbon atoms, -NH2 , -NHR4, -NR4R5, where R2 is chloro, bromo, formyl, -CH2 -COOH, -CH2-COOCH3 or -CH2-COOC2H5, R4 and R5 are each alkyl of 1 to 4 carbon atoms and X- it is a non-toxic anion; salts of said compound and hydrolyzable compounds in said compound. ** (See formula) ** where R6 and R7 are each alkyl of 1 to 6 carbon atoms, and where R6 and R7 can be joined together to form the group - (CH2) n- where n is a positive integer from 4 to 6, which process comprises -a) the ammoniation of 1,4-diiodobicyclo (2,2,2) octane or b) the attachment of a corresponding 4-alkylbicyclo [2,2,2] octane carboxylic acid or derivative thereof to the reaction of Hoffmann, Curtius or Schmidt; c) the acylation of a compound in which R1 is NH2 or NHR2 with a suitable acylating agent and the subjection of the acylamide optionally to reduction, or d) the reaction of a compound in which R1 is NH2 or NHR2 with a suitable alkylene oxide , haloalkane carboxylic acid or derivative thereof, alkyl halide, aminoalkyl halide, hydroxyalkyl halide or alkoxyalkyl halide, or e) the attachment of a corresponding 1-ol or 1-ene to the Ritter reaction, of) the reaction of a compound in which R1 is NHR2 or MR2R3 and wherein R2 and/or R3 contain an OH group with a halogenating agent and the subsequent substitution of the halogen atom for NH2, NHR4 or NR4R5 or g) the reaction of a compound in the that R1 is NH2 with benzaldehyde oh) the reaction of a compound wherein R1 is NR6R7 with an oxidation agent. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US27714163A | 1963-05-01 | 1963-05-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES299408A1 true ES299408A1 (en) | 1964-07-01 |
Family
ID=23059561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES299408A Expired ES299408A1 (en) | 1963-05-01 | 1964-04-30 | Procedure for the preparation of an anti-virus-provided composite (Machine-translation by Google Translate, not legally binding) |
Country Status (15)
| Country | Link |
|---|---|
| AT (6) | AT289058B (en) |
| BE (1) | BE646690A (en) |
| BR (1) | BR6458641D0 (en) |
| CH (1) | CH461470A (en) |
| DE (1) | DE1468759B2 (en) |
| DK (3) | DK121370B (en) |
| ES (1) | ES299408A1 (en) |
| FI (3) | FI43311B (en) |
| FR (1) | FR1472022A (en) |
| GB (1) | GB1054092A (en) |
| LU (1) | LU45912A1 (en) |
| MY (1) | MY6800045A (en) |
| NL (1) | NL6404759A (en) |
| NO (1) | NO116718B (en) |
| SE (4) | SE307573B (en) |
-
0
- GB GB1054092D patent/GB1054092A/en active Active
-
1964
- 1964-04-17 BE BE646690D patent/BE646690A/xx unknown
- 1964-04-20 LU LU45912D patent/LU45912A1/xx unknown
- 1964-04-21 DE DE19641468759 patent/DE1468759B2/en active Granted
- 1964-04-22 CH CH523764A patent/CH461470A/en unknown
- 1964-04-22 AT AT853269A patent/AT289058B/en not_active IP Right Cessation
- 1964-04-22 AT AT10125/67A patent/AT285568B/en not_active IP Right Cessation
- 1964-04-22 AT AT10126/67A patent/AT285569B/en not_active IP Right Cessation
- 1964-04-22 AT AT853169A patent/AT289057B/en not_active IP Right Cessation
- 1964-04-22 AT AT10124/67A patent/AT279578B/en active
- 1964-04-22 AT AT354564A patent/AT269104B/en active
- 1964-04-23 FI FI0862/64A patent/FI43311B/fi active
- 1964-04-23 BR BR158641/64A patent/BR6458641D0/en unknown
- 1964-04-29 NL NL6404759A patent/NL6404759A/xx unknown
- 1964-04-29 SE SE5361/64A patent/SE307573B/xx unknown
- 1964-04-29 DK DK215264AA patent/DK121370B/en unknown
- 1964-04-29 SE SE01716/67A patent/SE330691B/xx unknown
- 1964-04-30 ES ES299408A patent/ES299408A1/en not_active Expired
- 1964-04-30 FR FR973032A patent/FR1472022A/en not_active Expired
-
1965
- 1965-07-09 DK DK353065AA patent/DK114198B/en unknown
- 1965-07-09 DK DK352965AA patent/DK120078B/en unknown
-
1966
- 1966-01-24 NO NO16138366A patent/NO116718B/no unknown
-
1967
- 1967-02-07 SE SE01718/67A patent/SE325877B/xx unknown
- 1967-02-07 SE SE01717/67A patent/SE325876B/xx unknown
-
1968
- 1968-12-31 MY MY196845A patent/MY6800045A/en unknown
-
1969
- 1969-07-30 FI FI2265/69A patent/FI42716B/fi active
- 1969-07-30 FI FI2266/69A patent/FI42717B/fi active
Also Published As
| Publication number | Publication date |
|---|---|
| BR6458641D0 (en) | 1973-09-11 |
| AT289058B (en) | 1971-04-13 |
| GB1054092A (en) | |
| AT285569B (en) | 1970-11-10 |
| AT279578B (en) | 1970-03-10 |
| CH461470A (en) | 1968-08-31 |
| FI43311B (en) | 1970-11-30 |
| SE325877B (en) | 1970-07-13 |
| AT289057B (en) | 1971-04-13 |
| AT285568B (en) | 1970-11-10 |
| DE1468759B2 (en) | 1973-07-26 |
| FI42716B (en) | 1970-06-30 |
| AT269104B (en) | 1969-03-10 |
| DE1468759A1 (en) | 1969-07-03 |
| MY6800045A (en) | 1968-12-31 |
| FI42717B (en) | 1970-06-30 |
| SE325876B (en) | 1970-07-13 |
| DK121370B (en) | 1971-10-11 |
| SE330691B (en) | 1970-11-30 |
| NL6404759A (en) | 1964-11-02 |
| NO116718B (en) | 1969-05-12 |
| DK120078B (en) | 1971-04-05 |
| FR1472022A (en) | 1967-03-10 |
| DK114198B (en) | 1969-06-09 |
| LU45912A1 (en) | 1964-06-20 |
| BE646690A (en) | 1964-08-17 |
| SE307573B (en) | 1969-01-13 |
| DE1468759C3 (en) | 1974-03-07 |
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