GB1146110A - 5h-dibenzo[a,d]cycloheptene derivatives - Google Patents
5h-dibenzo[a,d]cycloheptene derivativesInfo
- Publication number
- GB1146110A GB1146110A GB16971/67A GB1697167A GB1146110A GB 1146110 A GB1146110 A GB 1146110A GB 16971/67 A GB16971/67 A GB 16971/67A GB 1697167 A GB1697167 A GB 1697167A GB 1146110 A GB1146110 A GB 1146110A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- hydrogen
- dibenzo
- cycloheptene
- alkynyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
Abstract
1,146,110. 5H-Dibenzo[a,d]cycloheptenes. DR. A. WANDER S.A. 13 April, 1967 [22 April, 1966], No. 16971/67. Heading C2C. Novel compounds of the general formula (and acid addition salts thereof), wherein R 1 is hydrogen or alkyl, R 2 is alkyl, alkenyl or alkynyl, R 3 is alkyl and one of R 4 and R 5 represents hydrogen, the other representing hydrogen or halogen or alkyl, are prepared: (i) by cleaving a quaternized N - alkyl - 5,11 - methyleneimino- 10,11 - dihydro - 5H - dibenzo[a,d]cycloheptene; (ii) by alkylating, alkenylating or alkynylating compounds corresponding to those illustrated above in which R 3 is hydrogen and R 2 is hydrogen, alkyl, alkenyl or alkynyl; or (iii) by the interaction of an amine, NHR 2 R 3 , and, for example, the appropriate 5-halomethyl - 5H - dibenzo[a,d]cycloheptene (the latter reactant may be replaced by corresponding compounds containing ester groups in place of the halo atom). Therapeutic compositions showing anticonvulsant activity contain as the active ingredient the above novel compounds and may be administered enterally or parenterally.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH589966A CH461475A (en) | 1966-04-22 | 1966-04-22 | Process for the preparation of cycloheptene derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1146110A true GB1146110A (en) | 1969-03-19 |
Family
ID=4301201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB16971/67A Expired GB1146110A (en) | 1966-04-22 | 1967-04-13 | 5h-dibenzo[a,d]cycloheptene derivatives |
Country Status (12)
| Country | Link |
|---|---|
| AT (1) | AT283302B (en) |
| BE (1) | BE697368A (en) |
| CH (1) | CH461475A (en) |
| CS (3) | CS158201B2 (en) |
| DE (1) | DE1643209A1 (en) |
| ES (1) | ES339453A1 (en) |
| FI (1) | FI47347C (en) |
| FR (1) | FR6501M (en) |
| GB (1) | GB1146110A (en) |
| GR (1) | GR36288B (en) |
| NL (1) | NL6705571A (en) |
| NO (1) | NO122245B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0470127A1 (en) * | 1989-04-14 | 1992-02-12 | State Of Oregon By And Through Oregon State Board Of Higher Education On Behalf Oregon Health Sc. Univ. And Oregon State Univ. | Pcp receptor ligands and the use thereof |
| US5688789A (en) * | 1989-04-14 | 1997-11-18 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | PCP receptor ligands and the use thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4870080A (en) * | 1987-08-10 | 1989-09-26 | Merck & Co., Inc. | Polyhydro derivatives of 10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine |
-
1966
- 1966-04-22 CH CH589966A patent/CH461475A/en unknown
-
1967
- 1967-04-13 GB GB16971/67A patent/GB1146110A/en not_active Expired
- 1967-04-13 DE DE19671643209 patent/DE1643209A1/en active Pending
- 1967-04-14 FI FI111267A patent/FI47347C/en active
- 1967-04-17 FR FR102959A patent/FR6501M/fr not_active Expired
- 1967-04-18 CS CS282767A patent/CS158201B2/cs unknown
- 1967-04-18 CS CS358667A patent/CS158203B2/cs unknown
- 1967-04-18 ES ES339453A patent/ES339453A1/en not_active Expired
- 1967-04-18 CS CS358567A patent/CS158202B2/cs unknown
- 1967-04-20 NL NL6705571A patent/NL6705571A/xx unknown
- 1967-04-21 NO NO16783267A patent/NO122245B/no unknown
- 1967-04-21 AT AT380067A patent/AT283302B/en not_active IP Right Cessation
- 1967-04-21 BE BE697368D patent/BE697368A/xx unknown
- 1967-04-22 GR GR670136288A patent/GR36288B/en unknown
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0470127A1 (en) * | 1989-04-14 | 1992-02-12 | State Of Oregon By And Through Oregon State Board Of Higher Education On Behalf Oregon Health Sc. Univ. And Oregon State Univ. | Pcp receptor ligands and the use thereof |
| EP0470127A4 (en) * | 1989-04-14 | 1992-06-24 | State Of Oregon By And Through The Oregon State Board Of Higher Education On Behalf Of The Oregon Health Sciences University | Pcp receptor ligands and the use thereof |
| US5688789A (en) * | 1989-04-14 | 1997-11-18 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education, Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | PCP receptor ligands and the use thereof |
| US6017910A (en) * | 1989-04-14 | 2000-01-25 | State Of Oregon, Acting By And Through The Oregon State Board Of Higher Education Acting For And On Behalf Of The Oregon Health Sciences University And The University Of Oregon | PCP receptor ligands and the use thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CS158202B2 (en) | 1974-10-15 |
| GR36288B (en) | 1969-01-20 |
| CH461475A (en) | 1968-08-31 |
| NL6705571A (en) | 1967-10-23 |
| ES339453A1 (en) | 1968-05-16 |
| CS158203B2 (en) | 1974-10-15 |
| FI47347B (en) | 1973-07-31 |
| DE1643209A1 (en) | 1971-01-21 |
| AT283302B (en) | 1970-08-10 |
| CS158201B2 (en) | 1974-10-15 |
| FR6501M (en) | 1968-12-02 |
| FI47347C (en) | 1973-11-12 |
| NO122245B (en) | 1971-06-07 |
| BE697368A (en) | 1967-10-23 |
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