GB1054010A - - Google Patents
Info
- Publication number
- GB1054010A GB1054010A GB1054010DA GB1054010A GB 1054010 A GB1054010 A GB 1054010A GB 1054010D A GB1054010D A GB 1054010DA GB 1054010 A GB1054010 A GB 1054010A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- halo
- oct
- groups
- substituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- -1 pyrrolidino, piperidino, piperazino Chemical group 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000002252 acyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- GOJUJUVQIVIZAV-UHFFFAOYSA-N 2-amino-4,6-dichloropyrimidine-5-carbaldehyde Chemical group NC1=NC(Cl)=C(C=O)C(Cl)=N1 GOJUJUVQIVIZAV-UHFFFAOYSA-N 0.000 abstract 1
- 229910010082 LiAlH Inorganic materials 0.000 abstract 1
- 238000005903 acid hydrolysis reaction Methods 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 238000005904 alkaline hydrolysis reaction Methods 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 230000000954 anitussive effect Effects 0.000 abstract 1
- 230000001754 anti-pyretic effect Effects 0.000 abstract 1
- 239000002221 antipyretic Substances 0.000 abstract 1
- 125000003710 aryl alkyl group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000003921 oil Substances 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 abstract 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 abstract 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 239000008174 sterile solution Substances 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 239000000829 suppository Substances 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
- 239000003826 tablet Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
- C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DET24890A DE1226115B (de) | 1963-10-14 | 1963-10-14 | Verfahren zur Herstellung von neuen Amino-halogen-benzylaminen |
| US40333964A | 1964-10-12 | 1964-10-12 | |
| DET0028358 | 1965-04-09 | ||
| GB54637/66A GB1154547A (en) | 1963-10-14 | 1966-12-06 | Substituted Benzylamines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1054010A true GB1054010A (en, 2012) |
Family
ID=27437631
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1054010D Active GB1054010A (en, 2012) | 1963-10-14 | ||
| GB1052509D Active GB1052509A (en, 2012) | 1963-10-14 | ||
| GB54637/66A Expired GB1154547A (en) | 1963-10-14 | 1966-12-06 | Substituted Benzylamines |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1052509D Active GB1052509A (en, 2012) | 1963-10-14 | ||
| GB54637/66A Expired GB1154547A (en) | 1963-10-14 | 1966-12-06 | Substituted Benzylamines |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US3336308A (en, 2012) |
| JP (1) | JPS4830044B1 (en, 2012) |
| BE (2) | BE654333A (en, 2012) |
| CH (7) | CH445515A (en, 2012) |
| DE (2) | DE1226115B (en, 2012) |
| DK (2) | DK120493B (en, 2012) |
| FI (1) | FI43998B (en, 2012) |
| FR (3) | FR1447971A (en, 2012) |
| GB (3) | GB1154547A (en, 2012) |
| NL (2) | NL6513188A (en, 2012) |
| SE (2) | SE312140B (en, 2012) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3520930A (en) * | 1964-12-31 | 1970-07-21 | Merck & Co Inc | Lower alkoxy-amino-benzylamines |
| DE1518372A1 (de) * | 1965-04-09 | 1969-06-26 | Thomae Gmbh Dr K | Verfahren zur Herstellung von neuen 2-Amino-benzylaminen |
| US4018556A (en) * | 1965-12-03 | 1977-04-19 | Societe Anonyme Dite: L'oreal | Hair dye compounds |
| DE1593579B1 (de) * | 1966-05-10 | 1972-02-03 | Thomae Gmbh Dr K | Hydroxy-cyclohexylamine,deren physiologisch vertraeglichen Saeureadditionssalze und Verfahren zu ihrer Herstellung |
| US4073942A (en) * | 1972-10-23 | 1978-02-14 | Boehringer Ingelheim Gmbh | Halo-substituted hydroxybenzyl-amines as secretolytic agents |
| US4101671A (en) * | 1973-04-13 | 1978-07-18 | Boehringer Ingelheim Gmbh | Aminobenzyl-amines and salts thereof |
| US3882179A (en) * | 1974-01-25 | 1975-05-06 | Morton Norwich Products Inc | 1-Veratrylamino-4-t-butylcyclohexylamine hydrochloride |
| IE40727B1 (en) * | 1974-03-09 | 1979-08-01 | Hoechst Ag | Aralkylamines |
| DE3209429A1 (de) * | 1982-03-16 | 1983-10-06 | Boehringer Ingelheim Vetmed | Mittel zur verbesserung der resorption von injizierten antibakteriell wirksamen substanzen und kombinationen, enthaltend ein benzyaminderivat |
| DE3485756D1 (de) * | 1983-09-17 | 1992-07-09 | Thomae Gmbh Dr K | Antiadhaesive prophylactica und arzneimittel enthaltend ein sekretolytisch wirksames benzylaminderivat. |
| DE19529432C1 (de) * | 1995-08-10 | 1997-05-15 | Boehringer Ingelheim Kg | Verfahren zur Herstellung von Benzylaminderivaten |
-
0
- GB GB1054010D patent/GB1054010A/en active Active
- NL NL129966D patent/NL129966C/xx active
- GB GB1052509D patent/GB1052509A/en active Active
-
1963
- 1963-10-14 DE DET24890A patent/DE1226115B/de active Pending
-
1964
- 1964-10-07 CH CH1301264A patent/CH445515A/de unknown
- 1964-10-07 CH CH954567A patent/CH448120A/de unknown
- 1964-10-07 CH CH954467A patent/CH445516A/de unknown
- 1964-10-09 SE SE12150/64A patent/SE312140B/xx unknown
- 1964-10-13 FR FR991265A patent/FR1447971A/fr not_active Expired
- 1964-10-13 BE BE654333D patent/BE654333A/xx unknown
- 1964-10-14 DK DK507864AA patent/DK120493B/da unknown
-
1965
- 1965-01-06 FR FR1017A patent/FR4121M/fr not_active Expired
- 1965-04-09 DE DE1518373A patent/DE1518373C3/de not_active Expired
- 1965-06-04 US US461492A patent/US3336308A/en not_active Expired - Lifetime
- 1965-10-05 FI FI2365/65A patent/FI43998B/fi active
- 1965-10-05 CH CH1370765A patent/CH460799A/de unknown
- 1965-10-05 CH CH988968A patent/CH460802A/de unknown
- 1965-10-05 CH CH988868A patent/CH460801A/de unknown
- 1965-10-05 CH CH988768A patent/CH460800A/de unknown
- 1965-10-11 BE BE670767D patent/BE670767A/xx unknown
- 1965-10-12 NL NL6513188A patent/NL6513188A/xx unknown
- 1965-10-12 SE SE13233/65A patent/SE332181B/xx unknown
- 1965-10-12 JP JP40062234A patent/JPS4830044B1/ja active Pending
- 1965-12-08 DK DK631865AA patent/DK116000B/da unknown
-
1966
- 1966-01-06 FR FR45006A patent/FR5127M/fr not_active Expired
- 1966-12-06 GB GB54637/66A patent/GB1154547A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CH460802A (de) | 1968-08-15 |
| CH448120A (de) | 1967-12-15 |
| US3336308A (en) | 1967-08-15 |
| FR1447971A (fr) | 1966-08-05 |
| CH460799A (de) | 1968-08-15 |
| NL6513188A (en, 2012) | 1966-04-13 |
| BE670767A (en, 2012) | 1966-04-12 |
| NL129966C (en, 2012) | |
| JPS4830044B1 (en, 2012) | 1973-09-17 |
| BE654333A (en, 2012) | 1965-04-13 |
| FI43998B (en, 2012) | 1971-04-30 |
| FR4121M (en, 2012) | 1966-04-25 |
| DK120493B (da) | 1971-06-07 |
| CH445515A (de) | 1967-10-31 |
| DE1518373B2 (de) | 1973-11-29 |
| GB1052509A (en, 2012) | |
| DE1226115B (de) | 1966-10-06 |
| CH460801A (de) | 1968-08-15 |
| SE312140B (en, 2012) | 1969-07-07 |
| CH460800A (de) | 1968-08-15 |
| CH445516A (de) | 1967-10-31 |
| DK116000B (da) | 1969-12-01 |
| DE1518373A1 (de) | 1969-12-18 |
| GB1154547A (en) | 1969-06-11 |
| DE1518373C3 (de) | 1974-07-04 |
| SE332181B (en, 2012) | 1971-02-01 |
| FR5127M (en, 2012) | 1967-06-05 |
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