GB1053063A - - Google Patents
Info
- Publication number
- GB1053063A GB1053063A GB1053063DA GB1053063A GB 1053063 A GB1053063 A GB 1053063A GB 1053063D A GB1053063D A GB 1053063DA GB 1053063 A GB1053063 A GB 1053063A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- compound
- amide
- atom
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 150000001875 compounds Chemical class 0.000 abstract 9
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 230000002152 alkylating effect Effects 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 150000001412 amines Chemical class 0.000 abstract 2
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical group [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- KZBUYRJDOAKODT-UHFFFAOYSA-N Chlorine Chemical compound ClCl KZBUYRJDOAKODT-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- -1 amide ester Chemical class 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001409 amidines Chemical class 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 150000004649 carbonic acid derivatives Chemical class 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 230000005494 condensation Effects 0.000 abstract 1
- 238000009833 condensation Methods 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 150000002825 nitriles Chemical class 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEF39784A DE1231705B (de) | 1963-05-18 | 1963-05-18 | Verfahren zur Herstellung von 2, 3-substituierten Chinazolon-(4)-derivaten |
| DEF0042147 | 1964-02-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1053063A true GB1053063A (US07906523-20110315-C00028.png) |
Family
ID=25975761
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1053063D Active GB1053063A (US07906523-20110315-C00028.png) | 1963-05-18 |
Country Status (10)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2100726A1 (US07906523-20110315-C00028.png) * | 1970-06-05 | 1972-03-24 | Byk Gulden Lomberg Chem Fab | |
| US4113637A (en) * | 1974-09-10 | 1978-09-12 | Institut Francais Du Petrole | Alkyl-guanidino-heterocyclic compounds, their manufacture and use as additives for fuels and lubricants |
Families Citing this family (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1003802A (en) * | 1963-06-04 | 1965-09-08 | Searle & Co | Pyrimidinone derivatives |
| GB1062357A (en) * | 1965-03-23 | 1967-03-22 | Pfizer & Co C | Quinazolone derivatives |
| US3900476A (en) * | 1973-05-17 | 1975-08-19 | Upjohn Co | 2(2'-pyrimidylamino)quinazolines and their preparation |
| US3936453A (en) * | 1974-01-28 | 1976-02-03 | Sandoz, Inc. | 1-Substituted-2-disubstituted aminoquin azolin-4(1h)-ones |
| US3959279A (en) * | 1974-01-28 | 1976-05-25 | Sandoz, Inc. | 1-Substituted-2-imino-quinazolin-4(1H)ones |
| GB8429739D0 (en) * | 1984-11-24 | 1985-01-03 | Fbc Ltd | Fungicides |
| US5756502A (en) * | 1994-08-08 | 1998-05-26 | Warner-Lambert Company | Quinazolinone derivatives as cholyecystokinin (CCK) ligands |
| WO1997010221A1 (en) * | 1995-09-15 | 1997-03-20 | Torrey Pines Institute For Molecular Studies | Synthesis of quinazolinone libraries |
| US6258819B1 (en) * | 1999-08-05 | 2001-07-10 | Syntex (U.S.A.) Llc | Substituted 2(4-piperidyl)-4(3H)-quinazolinones and 2-(4-piperidyl)-4(3H)-azaquinazolinones |
| US7671200B2 (en) * | 1999-10-27 | 2010-03-02 | Cytokinetics, Inc. | Quinazolinone KSP inhibitors |
| US7230000B1 (en) * | 1999-10-27 | 2007-06-12 | Cytokinetics, Incorporated | Methods and compositions utilizing quinazolinones |
| US6545004B1 (en) | 1999-10-27 | 2003-04-08 | Cytokinetics, Inc. | Methods and compositions utilizing quinazolinones |
| IL152275A0 (en) * | 2000-04-25 | 2003-05-29 | Icos Corp | Inhibitors of human phosphatidyl-inositol 3-kinase delta |
| US6667300B2 (en) | 2000-04-25 | 2003-12-23 | Icos Corporation | Inhibitors of human phosphatidylinositol 3-kinase delta |
| WO2002094790A1 (fr) * | 2001-05-23 | 2002-11-28 | Mitsubishi Pharma Corporation | Compose heterocyclique condense et son utilisation medicale |
| CA2465491A1 (en) * | 2001-11-07 | 2003-05-15 | Merck & Co., Inc. | Mitotic kinesin inhibitors |
| WO2003043995A1 (en) * | 2001-11-20 | 2003-05-30 | Cytokinetics, Inc. | Process for the racemization of chiral quinazolinones |
| US7009049B2 (en) * | 2002-02-15 | 2006-03-07 | Cytokinetics, Inc. | Syntheses of quinazolinones |
| JP2005530785A (ja) * | 2002-05-09 | 2005-10-13 | サイトキネティクス・インコーポレーテッド | 化合物、組成物、及び方法 |
| RU2004135554A (ru) * | 2002-05-09 | 2006-01-20 | Цитокинетикс, Инк. (Us) | Пиримидиноны, композиции на их основе и способы их использования |
| AU2003265242A1 (en) * | 2002-05-23 | 2003-12-22 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| US7041676B2 (en) * | 2002-06-14 | 2006-05-09 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| JP2006501201A (ja) * | 2002-07-23 | 2006-01-12 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
| WO2004018058A2 (en) * | 2002-08-21 | 2004-03-04 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| EP1558083A4 (en) * | 2002-09-30 | 2008-04-16 | Cytokinetics Inc | COMPOUNDS, COMPOSITIONS AND METHODS |
| EP1608317B1 (en) | 2003-03-25 | 2012-09-26 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| CN1867560A (zh) | 2003-08-13 | 2006-11-22 | 武田药品工株式会社 | 4－嘧啶酮衍生物及其作为肽基肽酶抑制剂的用途 |
| WO2005016348A1 (en) * | 2003-08-14 | 2005-02-24 | Icos Corporation | Method of inhibiting immune responses stimulated by an endogenous factor |
| US20050054614A1 (en) * | 2003-08-14 | 2005-03-10 | Diacovo Thomas G. | Methods of inhibiting leukocyte accumulation |
| US20050065144A1 (en) * | 2003-09-08 | 2005-03-24 | Syrrx, Inc. | Dipeptidyl peptidase inhibitors |
| EP1699777B1 (en) * | 2003-09-08 | 2012-12-12 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| US20050197327A1 (en) * | 2003-11-03 | 2005-09-08 | Gustave Bergnes | Compounds, compositions, and methods |
| WO2005046588A2 (en) * | 2003-11-07 | 2005-05-26 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| US7439254B2 (en) * | 2003-12-08 | 2008-10-21 | Cytokinetics, Inc. | Compounds, compositions, and methods |
| WO2005095381A1 (en) * | 2004-03-15 | 2005-10-13 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors |
| CN101031569B (zh) | 2004-05-13 | 2011-06-22 | 艾科斯有限公司 | 作为人磷脂酰肌醇3-激酶δ抑制剂的喹唑啉酮 |
| WO2005117889A1 (en) * | 2004-05-25 | 2005-12-15 | Icos Corporation | Methods for treating and/or preventing aberrant proliferation of hematopoietic |
| WO2006068978A2 (en) | 2004-12-21 | 2006-06-29 | Takeda Pharmaceutial Company Limited | Dipeptidyl peptidase inhibitors |
| US20080287469A1 (en) * | 2005-02-17 | 2008-11-20 | Diacovo Thomas G | Phosphoinositide 3-Kinase Inhibitors for Inhibiting Leukocyte Accumulation |
| DE102005024017A1 (de) * | 2005-05-25 | 2006-11-30 | Merck Patent Gmbh | Chinazolinone |
| US20070060529A1 (en) * | 2005-09-14 | 2007-03-15 | Christopher Ronald J | Administration of dipeptidyl peptidase inhibitors |
| EP1942898B2 (en) | 2005-09-14 | 2014-05-14 | Takeda Pharmaceutical Company Limited | Dipeptidyl peptidase inhibitors for treating diabetes |
| CN102675221A (zh) * | 2005-09-16 | 2012-09-19 | 武田药品工业株式会社 | 用于制备嘧啶二酮衍生物的方法中的中间体 |
| EP2010505B1 (en) * | 2006-03-28 | 2012-12-05 | Atir Holding S.A. | Heterocyclic compounds and uses thereof in the treatment of sexual disorders |
| US20100029941A1 (en) * | 2006-03-28 | 2010-02-04 | Takeda Pharmaceutical Company Limited | Preparation of (r)-3-aminopiperidine dihydrochloride |
| SI2073810T1 (sl) * | 2006-09-13 | 2011-12-30 | Takeda Pharmaceutical | Uporaba 2-6(3-amino-piperidin-1-il)-3-metil-2,4-diokso-3,4-dihidro-2H-pirimidin -1-ilmetil-4-fluoro-benzonitrila za zdravljenje diabetesa, raka, avtoimunskih motenj in infekcije s HIV |
| US8324383B2 (en) | 2006-09-13 | 2012-12-04 | Takeda Pharmaceutical Company Limited | Methods of making polymorphs of benzoate salt of 2-[[6-[(3R)-3-amino-1-piperidinyl]-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl]methyl]-benzonitrile |
| TW200838536A (en) * | 2006-11-29 | 2008-10-01 | Takeda Pharmaceutical | Polymorphs of succinate salt of 2-[6-(3-amino-piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-ylmethy]-4-fluor-benzonitrile and methods of use therefor |
| US8093236B2 (en) | 2007-03-13 | 2012-01-10 | Takeda Pharmaceuticals Company Limited | Weekly administration of dipeptidyl peptidase inhibitors |
| US9492449B2 (en) | 2008-11-13 | 2016-11-15 | Gilead Calistoga Llc | Therapies for hematologic malignancies |
| NZ592880A (en) | 2008-11-13 | 2013-06-28 | Gilead Calistoga Llc | Combinations of purine derivatives and proteasome inhibitors such as bortezomib for the treatment of hematological malignancy |
| JP2012521994A (ja) | 2009-03-24 | 2012-09-20 | ギリアード カリストガ エルエルシー | ２−プリニル−３−トリル−キナゾリノン誘導体のアトロプ異性体および使用方法 |
| EA201101507A1 (ru) * | 2009-04-20 | 2012-05-30 | Гилеад Калистога Ллс. | Способы лечения солидных опухолей |
| EA201270184A1 (ru) | 2009-07-21 | 2012-08-30 | ГИЛИЭД КАЛИСТОГА ЭлЭлСи | Лечение расстройств печени ингибиторами pi3k |
| US9353067B2 (en) | 2011-04-10 | 2016-05-31 | Atir Holding S.A. | Heterocyclic compounds and uses thereof in the treatment of sexual disorders |
| MD20140100A2 (ro) | 2012-03-05 | 2015-01-31 | Gilead Calistoga Llc | Forme polimorfe ale (S)-2-(1-(9H-purin-6-ilamino)propil)-5-fluoro-3-fenilchinazolin-4(3H)-onei |
| JP2017502021A (ja) | 2013-12-20 | 2017-01-19 | ギリアード カリストガ エルエルシー | ホスファチジルイノシトール３−キナーゼ阻害剤のためのプロセス方法 |
| CA2934534A1 (en) | 2013-12-20 | 2015-06-25 | Gilead Calistoga Llc | Polymorphic forms of a hydrochloride salt of (s)-2-(1-(9h-purin-6-ylamino)propyl)-5-fluoro-3-phenylquinazolin-4(3h)-one |
| KR20170012560A (ko) | 2014-06-13 | 2017-02-02 | 길리애드 사이언시즈, 인코포레이티드 | 포스파티딜이노시톨 3-키나제 억제제 |
-
0
- DE DENDAT1249281D patent/DE1249281B/de active Pending
- GB GB1053063D patent/GB1053063A/en active Active
-
1963
- 1963-05-18 DE DEF39784A patent/DE1231705B/de active Pending
-
1964
- 1964-05-14 CH CH90467A patent/CH447182A/de unknown
- 1964-05-14 CH CH90567A patent/CH447183A/de unknown
- 1964-05-14 CH CH628164A patent/CH447181A/de unknown
- 1964-05-14 SE SE5933/64A patent/SE314074B/xx unknown
- 1964-05-14 US US367568A patent/US3322756A/en not_active Expired - Lifetime
- 1964-05-15 DK DK531064AA patent/DK105765C/da active
- 1964-05-15 DK DK531164AA patent/DK106039C/da active
- 1964-05-15 AT AT774665A patent/AT258918B/de active
- 1964-05-15 DK DK245564AA patent/DK104409C/da active
- 1964-05-15 AT AT774565A patent/AT258917B/de active
- 1964-05-15 AT AT427764A patent/AT254193B/de active
- 1964-05-15 NL NL6405448A patent/NL6405448A/xx unknown
- 1964-05-19 BE BE648093A patent/BE648093A/xx unknown
- 1964-08-17 FR FR985329A patent/FR3806M/fr active Active
-
1965
- 1965-11-23 SE SE1512665A patent/SE314076B/xx unknown
- 1965-11-23 SE SE1512565A patent/SE314075B/xx unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2100726A1 (US07906523-20110315-C00028.png) * | 1970-06-05 | 1972-03-24 | Byk Gulden Lomberg Chem Fab | |
| US4113637A (en) * | 1974-09-10 | 1978-09-12 | Institut Francais Du Petrole | Alkyl-guanidino-heterocyclic compounds, their manufacture and use as additives for fuels and lubricants |
Also Published As
| Publication number | Publication date |
|---|---|
| NL6405448A (US07906523-20110315-C00028.png) | 1964-11-19 |
| DE1231705B (de) | 1967-01-05 |
| SE314076B (US07906523-20110315-C00028.png) | 1969-09-01 |
| BE648093A (US07906523-20110315-C00028.png) | 1964-11-19 |
| AT254193B (de) | 1967-05-10 |
| AT258917B (de) | 1967-12-27 |
| DK106039C (da) | 1966-12-12 |
| SE314075B (US07906523-20110315-C00028.png) | 1969-09-01 |
| SE314074B (US07906523-20110315-C00028.png) | 1969-09-01 |
| CH447182A (de) | 1967-11-30 |
| DK105765C (da) | 1966-11-07 |
| US3322756A (en) | 1967-05-30 |
| DE1249281B (US07906523-20110315-C00028.png) | |
| CH447181A (de) | 1967-11-30 |
| CH447183A (de) | 1967-11-30 |
| FR3806M (fr) | 1966-01-03 |
| AT258918B (de) | 1967-12-27 |
| DK104409C (da) | 1966-05-16 |
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