GB1093847A - 1-nitro-9-[ªÏ-(dialkylamino)-alkylamino]-acridines - Google Patents

1-nitro-9-[ªÏ-(dialkylamino)-alkylamino]-acridines

Info

Publication number
GB1093847A
GB1093847A GB2210965A GB2210965A GB1093847A GB 1093847 A GB1093847 A GB 1093847A GB 2210965 A GB2210965 A GB 2210965A GB 2210965 A GB2210965 A GB 2210965A GB 1093847 A GB1093847 A GB 1093847A
Authority
GB
United Kingdom
Prior art keywords
nitro
acridines
dialkylamino
alkylamino
phenol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2210965A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STAROGARDZKIE ZAKL FARMA
Original Assignee
STAROGARDZKIE ZAKL FARMA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PL104665A external-priority patent/PL51854B1/pl
Application filed by STAROGARDZKIE ZAKL FARMA filed Critical STAROGARDZKIE ZAKL FARMA
Publication of GB1093847A publication Critical patent/GB1093847A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
    • C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
    • C07D219/08—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Seasonings (AREA)
  • Pyridine Compounds (AREA)

Abstract

Novel 1 - nitro - 9 - [o - dialkylamino - alkylamino] -acridines of the formula <FORM:1093847/C2/1> and their acid addition salts, wherein R1 is a straight chain alkyl residue e.g. propyl and R2 is an alkyl group, e.g. CH3, are made by heating 1-nitro-9-chloro-acridine (obtainable by ring closure of N-(31-nitrophenyl)-anthranilic acid with POCl3 and fractional crystallization of the resulting mixture of 1- and 3-nitro-9-chloroacridines from cyclohexane/chloroform) with phenol or a ring substituted derivative of phenol for 5-30 minutes at 20-100 DEG C., adding an amine (R2)2N-R1-NH2 and heating for a further 15-60 minutes at 80-100 DEG C.
GB2210965A 1964-05-25 1965-05-25 1-nitro-9-[ªÏ-(dialkylamino)-alkylamino]-acridines Expired GB1093847A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PL104665A PL51854B1 (en) 1964-05-25

Publications (1)

Publication Number Publication Date
GB1093847A true GB1093847A (en) 1967-12-06

Family

ID=19942345

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2210965A Expired GB1093847A (en) 1964-05-25 1965-05-25 1-nitro-9-[ªÏ-(dialkylamino)-alkylamino]-acridines

Country Status (5)

Country Link
CH (1) CH440280A (en)
DE (1) DE1620473C3 (en)
FR (1) FR1458183A (en)
GB (1) GB1093847A (en)
SE (1) SE323373B (en)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3694448A (en) * 1968-08-31 1972-09-26 Andrzej Ledochowski 1-nitro-9-(dialkylaminoalkylamino)acridine n{11 oxides
JPS52102282A (en) * 1976-02-25 1977-08-27 Politechnika Gdanska 11nitroo99alkylaminoalkylamino acridine and its salt and method of their preparation
JPS52151178A (en) * 1976-04-06 1977-12-15 Politechnika Gdanska Production of 11nitroo99 dialkylaminoisoalkylamino acridine and salts thereof
DE3207021A1 (en) * 1981-02-27 1982-09-23 Biogal Gyógyszergyár, 4042 Debrecen AMINOACRIDINE- (ALPHA) - AND / OR (BETA) - (D) -N-GLYCOSIDE- AND / OR AMINOACRIDINE- (ALPHA) - AND / OR (BETA) - (L) -N-GLYCOSIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4696936A (en) * 1984-11-09 1987-09-29 American Cyanamid Company 3,6-bis (substituted) acridine N-oxides and N,N-dioxides and methods of restoring, stimulating or enhancing the immune system with them

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3694448A (en) * 1968-08-31 1972-09-26 Andrzej Ledochowski 1-nitro-9-(dialkylaminoalkylamino)acridine n{11 oxides
JPS52102282A (en) * 1976-02-25 1977-08-27 Politechnika Gdanska 11nitroo99alkylaminoalkylamino acridine and its salt and method of their preparation
US4139531A (en) 1976-02-25 1979-02-13 Politechnika Gdanska 1-Nitro-9-alkylaminoalkylaminoacridines and salts thereof
JPS556630B2 (en) * 1976-02-25 1980-02-18
JPS52151178A (en) * 1976-04-06 1977-12-15 Politechnika Gdanska Production of 11nitroo99 dialkylaminoisoalkylamino acridine and salts thereof
US4150231A (en) * 1976-04-06 1979-04-17 Politechnika Gdanska 1-Nitro-9-dialkylaminoisoalkylaminoacridines or their salts
JPS5527908B2 (en) * 1976-04-06 1980-07-24
DE3207021A1 (en) * 1981-02-27 1982-09-23 Biogal Gyógyszergyár, 4042 Debrecen AMINOACRIDINE- (ALPHA) - AND / OR (BETA) - (D) -N-GLYCOSIDE- AND / OR AMINOACRIDINE- (ALPHA) - AND / OR (BETA) - (L) -N-GLYCOSIDE DERIVATIVES, METHOD FOR THE PRODUCTION THEREOF AND MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS

Also Published As

Publication number Publication date
FR1458183A (en) 1966-11-10
DE1620473A1 (en) 1970-02-19
DE1620473B2 (en) 1979-06-28
CH440280A (en) 1967-07-31
SE323373B (en) 1970-05-04
DE1620473C3 (en) 1980-03-20

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