GB1030626A - New phenothiazineamides - Google Patents

Abstract

The invention comprises compounds of the general formula <FORM:1030626/C2/1> wherein X1 and X2 which may be the same or different represent straight or branched chain alkylene groups having 1 to 3 carbon atoms, R represents an aliphatic, alicyclic, araliphatic, aromatic or heterocyclic acyl radical optionally substituted by halogen atoms or hydroxy, alkoxy, or tertiary amino groups, A and B represent hydrogen or halogen atoms or alkoxy radicals, their non-toxic acid addition salts and quaternary ammonium derivatives and the preparation thereof by either reacting a compound of the formula <FORM:1030626/C2/2> with a compound Q2-R (III) in which Q1 and Q2 represent groups able to react with each other to form a group of the formula <FORM:1030626/C2/3> or by esterifying a compound of the general formula <FORM:1030626/C2/4> or a reactive derivative thereof with a carboxylic acid R-OH, (VI), or a reactive derivative thereof, or by reacting a compound of the formula <FORM:1030626/C2/5> with a compound of the formula <FORM:1030626/C2/6> Compounds of Formula V are prepared by reacting a compound of the formula <FORM:1030626/C2/7> wherein Y represents the acid residue of a reactive ester, with a piperazine derivative <FORM:1030626/C2/8> 3 - Methoxy - 10 - chloroacetylphenothiazine is prepared from 3-methoxyphenothiazine and chloroacetylchloride. Similarly is prepared 2,3-dimethoxy -10 - chloroacetylphenothiazine, and 3-methoxy- and 2,3-dimethoxy-10-(b -chloro-propionyl) phenothiazine.