GB1028563A - Antibacterial derivative of 7-aminocephalosporanic acid - Google Patents
Antibacterial derivative of 7-aminocephalosporanic acidInfo
- Publication number
- GB1028563A GB1028563A GB47316/62A GB4731662A GB1028563A GB 1028563 A GB1028563 A GB 1028563A GB 47316/62 A GB47316/62 A GB 47316/62A GB 4731662 A GB4731662 A GB 4731662A GB 1028563 A GB1028563 A GB 1028563A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- thienylacetylated
- pyridinium
- carboxylate
- pyridine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- HSHGZXNAXBPPDL-HZGVNTEJSA-N 7beta-aminocephalosporanic acid Chemical class S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H]([NH3+])[C@@H]12 HSHGZXNAXBPPDL-HZGVNTEJSA-N 0.000 title abstract 2
- 230000000844 anti-bacterial effect Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 2
- -1 2-thienylacetyl Chemical group 0.000 abstract 1
- XVMSFILGAMDHEY-UHFFFAOYSA-N 6-(4-aminophenyl)sulfonylpyridin-3-amine Chemical compound C1=CC(N)=CC=C1S(=O)(=O)C1=CC=C(N)C=N1 XVMSFILGAMDHEY-UHFFFAOYSA-N 0.000 abstract 1
- HOKIDJSKDBPKTQ-GLXFQSAKSA-N Cephalosporin C Natural products S1CC(COC(=O)C)=C(C(O)=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H](N)C(O)=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-N 0.000 abstract 1
- 229930182555 Penicillin Natural products 0.000 abstract 1
- 239000004098 Tetracycline Substances 0.000 abstract 1
- 239000003242 anti bacterial agent Substances 0.000 abstract 1
- 229940088710 antibiotic agent Drugs 0.000 abstract 1
- HOKIDJSKDBPKTQ-GLXFQSAKSA-M cephalosporin C(1-) Chemical compound S1CC(COC(=O)C)=C(C([O-])=O)N2C(=O)[C@@H](NC(=O)CCC[C@@H]([NH3+])C([O-])=O)[C@@H]12 HOKIDJSKDBPKTQ-GLXFQSAKSA-M 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000002960 penicillins Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 235000019364 tetracycline Nutrition 0.000 abstract 1
- 150000003522 tetracyclines Chemical class 0.000 abstract 1
- 229940040944 tetracyclines Drugs 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
- C07D501/46—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by carboxylic acids containing hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B60—VEHICLES IN GENERAL
- B60G—VEHICLE SUSPENSION ARRANGEMENTS
- B60G11/00—Resilient suspensions characterised by arrangement, location or kind of springs
- B60G11/18—Resilient suspensions characterised by arrangement, location or kind of springs having torsion-bar springs only
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Mechanical Engineering (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Priority Applications (18)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB47316/62A GB1028563A (en) | 1962-12-14 | 1962-12-14 | Antibacterial derivative of 7-aminocephalosporanic acid |
| DK581363AA DK121861B (da) | 1962-12-14 | 1963-12-13 | Analogifremgangsmåde til fremstilling af N-(7-2'-tienylacetamidoceph-3-em-3-ylmetyl)-pyridinium-4-karboxylat. |
| SE13901/63A SE320073B (enExample) | 1962-12-14 | 1963-12-13 | |
| BR155431/63A BR6355431D0 (pt) | 1962-12-14 | 1963-12-13 | Processo para a producao de um derivado de acido 7-amino-cefalosporanico |
| DE19631445828 DE1445828A1 (de) | 1962-12-14 | 1963-12-14 | Neues Cephalosporansaeurederivat und Verfahren zu seiner Herstellung |
| CS732868*1A CS154598B2 (enExample) | 1962-12-14 | 1963-12-14 | |
| CS690863A CS158177B2 (enExample) | 1962-12-14 | 1963-12-14 | |
| DE19631795600 DE1795600C3 (de) | 1962-12-14 | 1963-12-14 | Cephalosporinderivate und Verfahren zu deren Herstellung |
| AT1011063A AT249861B (de) | 1962-12-14 | 1963-12-16 | Verfahren zur Herstellung neuer Derivate der 7-Aminocephalosporansäure |
| CH1540763A CH442310A (de) | 1962-12-14 | 1963-12-16 | Verfahren zur Herstellung eines Derivates der 7-Aminocephalosporansäure |
| CH767567A CH469023A (de) | 1962-12-14 | 1963-12-16 | Verfahren zur Herstellung von Derivaten der 7-Aminocephalosporansäure |
| CA969,425A CA973879A (en) | 1962-12-14 | 1966-09-02 | Cephalosporanic acid derivatives |
| CY41567A CY415A (en) | 1962-12-14 | 1967-11-14 | Antibacterial derivative of 7-aminocephalosporanic acid |
| SE18134/67A SE350509B (enExample) | 1962-12-14 | 1967-12-29 | |
| MY19689A MY6800009A (en) | 1962-12-14 | 1968-12-31 | Antibacterial derivative of t-aminocephalosporanic acid |
| DK190771AA DK125138C (da) | 1962-12-14 | 1971-04-21 | Analogifremgangsmåde til fremstilling af cephalosporinforbindelser. |
| DK01907/71A DK125138B (enExample) | 1962-12-14 | 1971-04-21 | |
| NL7304127A NL7304127A (enExample) | 1962-12-14 | 1973-03-23 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB47316/62A GB1028563A (en) | 1962-12-14 | 1962-12-14 | Antibacterial derivative of 7-aminocephalosporanic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1028563A true GB1028563A (en) | 1966-05-04 |
Family
ID=10444515
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB47316/62A Expired GB1028563A (en) | 1962-12-14 | 1962-12-14 | Antibacterial derivative of 7-aminocephalosporanic acid |
Country Status (11)
| Country | Link |
|---|---|
| AT (1) | AT249861B (enExample) |
| BR (1) | BR6355431D0 (enExample) |
| CH (2) | CH469023A (enExample) |
| CS (2) | CS154598B2 (enExample) |
| CY (1) | CY415A (enExample) |
| DE (1) | DE1445828A1 (enExample) |
| DK (3) | DK121861B (enExample) |
| GB (1) | GB1028563A (enExample) |
| MY (1) | MY6800009A (enExample) |
| NL (1) | NL7304127A (enExample) |
| SE (2) | SE320073B (enExample) |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536705A (en) * | 1968-03-11 | 1970-10-27 | Lilly Co Eli | Delta**2-cephalosporin ester intermediate |
| US3624225A (en) * | 1966-06-24 | 1971-11-30 | Glaxo Lab Ltd | Cephalosporin compositions |
| US4369313A (en) | 1979-05-25 | 1983-01-18 | Glaxo Group Limited | Intermediates for use in the preparation of cephalosporin antibiotics |
| CN107793433A (zh) * | 2017-11-15 | 2018-03-13 | 中国医药集团总公司四川抗菌素工业研究所 | 一种头孢噻啶的制备方法 |
-
1962
- 1962-12-14 GB GB47316/62A patent/GB1028563A/en not_active Expired
-
1963
- 1963-12-13 DK DK581363AA patent/DK121861B/da unknown
- 1963-12-13 BR BR155431/63A patent/BR6355431D0/pt unknown
- 1963-12-13 SE SE13901/63A patent/SE320073B/xx unknown
- 1963-12-14 CS CS732868*1A patent/CS154598B2/cs unknown
- 1963-12-14 CS CS690863A patent/CS158177B2/cs unknown
- 1963-12-14 DE DE19631445828 patent/DE1445828A1/de not_active Withdrawn
- 1963-12-16 AT AT1011063A patent/AT249861B/de active
- 1963-12-16 CH CH767567A patent/CH469023A/de unknown
- 1963-12-16 CH CH1540763A patent/CH442310A/de unknown
-
1967
- 1967-11-14 CY CY41567A patent/CY415A/xx unknown
- 1967-12-29 SE SE18134/67A patent/SE350509B/xx unknown
-
1968
- 1968-12-31 MY MY19689A patent/MY6800009A/xx unknown
-
1971
- 1971-04-21 DK DK01907/71A patent/DK125138B/da unknown
- 1971-04-21 DK DK190771AA patent/DK125138C/da active
-
1973
- 1973-03-23 NL NL7304127A patent/NL7304127A/xx unknown
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3624225A (en) * | 1966-06-24 | 1971-11-30 | Glaxo Lab Ltd | Cephalosporin compositions |
| US3536705A (en) * | 1968-03-11 | 1970-10-27 | Lilly Co Eli | Delta**2-cephalosporin ester intermediate |
| US4369313A (en) | 1979-05-25 | 1983-01-18 | Glaxo Group Limited | Intermediates for use in the preparation of cephalosporin antibiotics |
| US4433141A (en) * | 1979-05-25 | 1984-02-21 | Glaxo Group Limited | Intermediate for use in the preparation of cephalosporin antibiotics |
| CN107793433A (zh) * | 2017-11-15 | 2018-03-13 | 中国医药集团总公司四川抗菌素工业研究所 | 一种头孢噻啶的制备方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| CH469023A (de) | 1969-02-28 |
| CH442310A (de) | 1967-08-31 |
| BR6355431D0 (pt) | 1973-09-20 |
| CS158177B2 (enExample) | 1974-10-15 |
| DK125138B (enExample) | 1973-01-02 |
| AT249861B (de) | 1966-10-10 |
| DE1445828A1 (de) | 1969-04-17 |
| MY6800009A (en) | 1968-12-31 |
| DK125138C (da) | 1973-07-02 |
| DK121861B (da) | 1971-12-13 |
| DE1795600B2 (de) | 1975-09-25 |
| SE320073B (enExample) | 1970-02-02 |
| CY415A (en) | 1967-11-14 |
| CS154598B2 (enExample) | 1974-04-30 |
| DE1795600A1 (de) | 1972-01-27 |
| NL7304127A (enExample) | 1973-06-25 |
| SE350509B (enExample) | 1972-10-30 |
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