GB1021112A - A new salt and a new process for the recovery of kanamycin - Google Patents

A new salt and a new process for the recovery of kanamycin

Info

Publication number
GB1021112A
GB1021112A GB24044/63A GB2404463A GB1021112A GB 1021112 A GB1021112 A GB 1021112A GB 24044/63 A GB24044/63 A GB 24044/63A GB 2404463 A GB2404463 A GB 2404463A GB 1021112 A GB1021112 A GB 1021112A
Authority
GB
United Kingdom
Prior art keywords
kanamycin
lauryl sulphate
new
sulphate
lauryl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB24044/63A
Inventor
Gerardo Fabrizio
Aristide Sarcina
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierrel SpA
Original Assignee
Pierrel SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel SpA filed Critical Pierrel SpA
Priority to GB24044/63A priority Critical patent/GB1021112A/en
Priority to BR159683/64A priority patent/BR6459683D0/en
Priority to DK286864AA priority patent/DK104047C/en
Priority to NL6406754A priority patent/NL6406754A/xx
Publication of GB1021112A publication Critical patent/GB1021112A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/46—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin
    • C12P19/48—Preparation of O-glycosides, e.g. glucosides having an oxygen atom of the saccharide radical bound to a cyclohexyl radical, e.g. kasugamycin the cyclohexyl radical being substituted by two or more nitrogen atoms, e.g. destomycin, neamin
    • C12P19/485—Having two saccharide radicals bound through only oxygen to non-adjacent ring carbons of the cyclohexyl radical, e.g. gentamycin, kanamycin, sisomycin, verdamycin, mutamycin, tobramycin, nebramycin, antibiotics 66-40B, 66-40D, XK-62-2, 66-40, G-418, G-52
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention relates to kanamycin lauryl sulphate. Kanamycin lauryl sulphate is obtained by the addition of sodium lauryl sulphate to a clarified culture broth of Streptomyces Kanamyceticus at pH 2 to 6 and especially 3.8. Kanamycin sulphate may be obtained from kanamycin lauryl sulphate by dissolving in water, adjusting to pH 9 to 11 by means of an organic or inorganic base, precipitating the lauryl sulphuric anion with Ba(OH)2, separating the precipitate and creating the residual aqueous solution with activated charcoal, adjusting to pH 8.0 with H2SO4 and finally adding methanol or acetone. Alternatively, the kanamycin lauryl sulphate may be dissolved in methanol, the pH adjusted to 8 with ammonia and lauryl sulphate precipitated by addition of sulphuric acid.
GB24044/63A 1963-06-17 1963-06-17 A new salt and a new process for the recovery of kanamycin Expired GB1021112A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB24044/63A GB1021112A (en) 1963-06-17 1963-06-17 A new salt and a new process for the recovery of kanamycin
BR159683/64A BR6459683D0 (en) 1963-06-17 1964-06-03 PROCESS OF OBTAINING KANAMICINE LAURYL-SULFATE AND RECOVERY OF THE SAME
DK286864AA DK104047C (en) 1963-06-17 1964-06-09 Process for recovering kanamycin in the form of the free base or a salt thereof.
NL6406754A NL6406754A (en) 1963-06-17 1964-06-15

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB24044/63A GB1021112A (en) 1963-06-17 1963-06-17 A new salt and a new process for the recovery of kanamycin

Publications (1)

Publication Number Publication Date
GB1021112A true GB1021112A (en) 1966-02-23

Family

ID=10205488

Family Applications (1)

Application Number Title Priority Date Filing Date
GB24044/63A Expired GB1021112A (en) 1963-06-17 1963-06-17 A new salt and a new process for the recovery of kanamycin

Country Status (4)

Country Link
BR (1) BR6459683D0 (en)
DK (1) DK104047C (en)
GB (1) GB1021112A (en)
NL (1) NL6406754A (en)

Also Published As

Publication number Publication date
NL6406754A (en) 1964-12-18
DK104047C (en) 1966-03-28
BR6459683D0 (en) 1973-08-02

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