GB1019468A - New pyrido-benzodiazepine derivatives, process for their production and compositions containing them - Google Patents
New pyrido-benzodiazepine derivatives, process for their production and compositions containing themInfo
- Publication number
- GB1019468A GB1019468A GB50608/63A GB5060863A GB1019468A GB 1019468 A GB1019468 A GB 1019468A GB 50608/63 A GB50608/63 A GB 50608/63A GB 5060863 A GB5060863 A GB 5060863A GB 1019468 A GB1019468 A GB 1019468A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compound
- compounds
- general formula
- hydrogen
- give
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention comprises compounds of the general formula <FORM:1019468/C2/1> wherein R1 and R2 independently represent hydrogen, halogen, the trifluoromethyl group, the cyano group, or a C1- 6 alkyl or alkoxy radical, their pharmaceutically acceptable acid addition salts, their quaternary ammonium salts and their N-oxides. The compounds are prepared by reacting a compound of the general formula <FORM:1019468/C2/2> in which R3 represents hydrogen or a C1- 6 alkyl radical and R1 and R2 are as defined above, with a mineral acid, followed, if desired, by conversion to an acid addition salt, a quaternary ammonium compound or an N-oxide. The starting materials of Formula II above can be prepared by reacting a compound of the general formula <FORM:1019468/C2/3> in which Hal represents a halogen atom, in the presence of an acid binding agent with a compound of the general formula <FORM:1019468/C2/4> in which R31 has the meaning given for R3 with the exception of hydrogen, to give a compound of the general formula <FORM:1019468/C2/5> which is then reduced to give a compound of Formula II above in which R3 is C1- 6 alkyl; the product may be saponified to give a compound in which R3 is hydrogen. The invention also comprises medicaments containing at least one of the compounds of the invention together with at least one pharmaceutically acceptable carrier. The compounds of the invention have anti-convulsive and muscle-relaxing activity, have depressant action on the central nervous system, and influence the blood pressure. The compounds may be used as tranquillizers either per os or, in the form of aqueous solutions of their salts, quaternary ammonium compounds or of the N-oxides, also parenterally.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24733562A | 1962-12-26 | 1962-12-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1019468A true GB1019468A (en) | 1966-02-09 |
Family
ID=22934527
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB50608/63A Expired GB1019468A (en) | 1962-12-26 | 1963-12-23 | New pyrido-benzodiazepine derivatives, process for their production and compositions containing them |
Country Status (6)
| Country | Link |
|---|---|
| AT (1) | AT243812B (en) |
| CH (1) | CH428749A (en) |
| DE (1) | DE1207939B (en) |
| DK (1) | DK103886C (en) |
| ES (1) | ES294841A1 (en) |
| GB (1) | GB1019468A (en) |
-
1963
- 1963-12-06 CH CH1495363A patent/CH428749A/en unknown
- 1963-12-23 GB GB50608/63A patent/GB1019468A/en not_active Expired
- 1963-12-23 DE DEG39467A patent/DE1207939B/en active Granted
- 1963-12-23 DK DK602163AA patent/DK103886C/en active
- 1963-12-24 ES ES0294841A patent/ES294841A1/en not_active Expired
- 1963-12-24 AT AT1041763A patent/AT243812B/en active
Also Published As
| Publication number | Publication date |
|---|---|
| DK103886C (en) | 1966-03-07 |
| AT243812B (en) | 1965-12-10 |
| CH428749A (en) | 1967-01-31 |
| ES294841A1 (en) | 1964-05-16 |
| DE1207939C2 (en) | 1966-07-07 |
| DE1207939B (en) | 1965-12-30 |
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