ES294841A1 - New pyrido-benzodiazepine derivatives, process for their production and compositions containing them - Google Patents

New pyrido-benzodiazepine derivatives, process for their production and compositions containing them

Info

Publication number
ES294841A1
ES294841A1 ES0294841A ES294841A ES294841A1 ES 294841 A1 ES294841 A1 ES 294841A1 ES 0294841 A ES0294841 A ES 0294841A ES 294841 A ES294841 A ES 294841A ES 294841 A1 ES294841 A1 ES 294841A1
Authority
ES
Spain
Prior art keywords
compound
compounds
general formula
hydrogen
give
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES0294841A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
JR Geigy AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by JR Geigy AG filed Critical JR Geigy AG
Publication of ES294841A1 publication Critical patent/ES294841A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

The invention comprises compounds of the general formula <FORM:1019468/C2/1> wherein R1 and R2 independently represent hydrogen, halogen, the trifluoromethyl group, the cyano group, or a C1- 6 alkyl or alkoxy radical, their pharmaceutically acceptable acid addition salts, their quaternary ammonium salts and their N-oxides. The compounds are prepared by reacting a compound of the general formula <FORM:1019468/C2/2> in which R3 represents hydrogen or a C1- 6 alkyl radical and R1 and R2 are as defined above, with a mineral acid, followed, if desired, by conversion to an acid addition salt, a quaternary ammonium compound or an N-oxide. The starting materials of Formula II above can be prepared by reacting a compound of the general formula <FORM:1019468/C2/3> in which Hal represents a halogen atom, in the presence of an acid binding agent with a compound of the general formula <FORM:1019468/C2/4> in which R31 has the meaning given for R3 with the exception of hydrogen, to give a compound of the general formula <FORM:1019468/C2/5> which is then reduced to give a compound of Formula II above in which R3 is C1- 6 alkyl the product may be saponified to give a compound in which R3 is hydrogen. The invention also comprises medicaments containing at least one of the compounds of the invention together with at least one pharmaceutically acceptable carrier. The compounds of the invention have anti-convulsive and muscle-relaxing activity, have depressant action on the central nervous system, and influence the blood pressure. The compounds may be used as tranquillizers either per os or, in the form of aqueous solutions of their salts, quaternary ammonium compounds or of the N-oxides, also parenterally.
ES0294841A 1962-12-26 1963-12-24 New pyrido-benzodiazepine derivatives, process for their production and compositions containing them Expired ES294841A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US24733562A 1962-12-26 1962-12-26

Publications (1)

Publication Number Publication Date
ES294841A1 true ES294841A1 (en) 1964-05-16

Family

ID=22934527

Family Applications (1)

Application Number Title Priority Date Filing Date
ES0294841A Expired ES294841A1 (en) 1962-12-26 1963-12-24 New pyrido-benzodiazepine derivatives, process for their production and compositions containing them

Country Status (6)

Country Link
AT (1) AT243812B (en)
CH (1) CH428749A (en)
DE (1) DE1207939B (en)
DK (1) DK103886C (en)
ES (1) ES294841A1 (en)
GB (1) GB1019468A (en)

Also Published As

Publication number Publication date
DK103886C (en) 1966-03-07
AT243812B (en) 1965-12-10
GB1019468A (en) 1966-02-09
CH428749A (en) 1967-01-31
DE1207939C2 (en) 1966-07-07
DE1207939B (en) 1965-12-30

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